The Pathways of Oxygen in Brain II
- 1.4k Downloads
It has been well-known for many years that cerebral oxygen consumption remains constant during moderate changes of blood flow, as measured during hypo- or hypercapnia or indomethacin administration. Current models of flow-metabolism coupling link blood-brain transfer of oxygen to oxygen metabolism in mitochondria.2–6 The resulting quantitative relations between flow and metabolism reveal that a close link between diffusion and metabolism prevents the enzyme from maintaining a constant oxygen consumption when blood flow changes, unless the enzyme’s affinity towards oxygen is adjusted commensurately.
KeywordsCerebral Blood Flow Cytochrome Oxidase Oxygen Consumption Rate Blood Flow Rate Oxygen Metabolism
Unable to display preview. Download preview PDF.
- 2.A. Gjedde, S. Ohta, H. Kuwabara, and E. Meyer, Is oxygen diffusion limiting for bloodbrain transfer of oxygen? in: Brain Work and Mental Activity, Alfred Benzon Symposium 31, edited by N. A. Lassen, D. H. Ingvar, M. E. Raichle, and L. Friberg (Munksgaard, Copenhagen, 1991), pp. 177–184.Google Scholar
- 3.A. Gjedde, The relation between brain function and cerebral blood flow and metabolism, in: Cerebrovascular Disease, edited by H. H. Batjer (Lippincott-Raven, Philadelphia, 1997), pp. 23–40.Google Scholar
- 11.E. M. Nemoto, H. Yonas, H. Kuwabara, R. R. Pindsola, D. Sashin, C. C. Meltzer, J. C. Price, and Y. Chang, Detection of stage II compromised cerebrovascular reserve by xenon CT cerebral blood flow with acetazolamide and oxygen extraction fraction by positron emission tomography, in: Brain Imaging Using PET, edited by M. Senda, and P. Herscovitch (Elsevier, San Diego, 2002).Google Scholar