The Pathways of Oxygen in Brain II

Competitions for cytochrome c oxidase and NOS are keys to flow-metabolism coupling
  • Albert Gjedde
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 566)


It has been well-known for many years that cerebral oxygen consumption remains constant during moderate changes of blood flow, as measured during hypo- or hypercapnia or indomethacin administration. Current models of flow-metabolism coupling link blood-brain transfer of oxygen to oxygen metabolism in mitochondria.2–6 The resulting quantitative relations between flow and metabolism reveal that a close link between diffusion and metabolism prevents the enzyme from maintaining a constant oxygen consumption when blood flow changes, unless the enzyme’s affinity towards oxygen is adjusted commensurately.


Cerebral Blood Flow Cytochrome Oxidase Oxygen Consumption Rate Blood Flow Rate Oxygen Metabolism 
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© Springer Science+Business Media, Inc. 2005

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  • Albert Gjedde

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