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The Pathways of Oxygen in Brain II

Competitions for cytochrome c oxidase and NOS are keys to flow-metabolism coupling
  • Albert Gjedde
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 566)

Abstract

It has been well-known for many years that cerebral oxygen consumption remains constant during moderate changes of blood flow, as measured during hypo- or hypercapnia or indomethacin administration. Current models of flow-metabolism coupling link blood-brain transfer of oxygen to oxygen metabolism in mitochondria.2–6 The resulting quantitative relations between flow and metabolism reveal that a close link between diffusion and metabolism prevents the enzyme from maintaining a constant oxygen consumption when blood flow changes, unless the enzyme’s affinity towards oxygen is adjusted commensurately.

Keywords

Cerebral Blood Flow Cytochrome Oxidase Oxygen Consumption Rate Blood Flow Rate Oxygen Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Albert Gjedde

There are no affiliations available

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