Abstract
For millennia there has been interest in the potential therapeutic effects of marijuana (cannabis), including its potential antiepileptic effects. A flurry of research on cannabis and seizures occurred in the 1970s, when purified tetrahydrocannabinol (THC) became available for research. The results demonstrated that a variety of seizures, including kindled seizures can be suppressed by THC, but typically at toxic doses.1–3 It was also reported that prophylactic administration of THC can delay limbic kindling in rats2 and cats.3 In contrast, other studies that received less attention described proepileptic or proconvulsant effects of a variety of cannabinoids, including THC.4–6 Because of a lack of knowledge about the mechanisms of cannabis’s effects oh the brain, research on cannabis and epilepsy declined to a very low level in the 1980s.
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6. References
J. A. McCaughran, M. E. Corcoran, and J. A. Wada, Anticonvulsant activity of delta 8-and delta 9 tetrahydrocannabinol in rats, Pharmacol. Biochem. Behav. 2 227–233 (1974).
M E. Corcoran, J. A. MCCaughran, and J. A. Wada, Antiepileptic and prophylactic effects of tetrahydrocannabinols in amygdaloid kindled rats, Epilepsia, 19 47–55 (1978).
J. A. Wada, A. Wake, M. Sato, and M. E. Corcoran, Antiepileptic and prophylactic effects of tetrahydrocannabinols in amygdaloid kindled cats, Epilepsia 16, 503–510 (1975).
P. Consroe, B. Jones, H. Laird-II, and J. Reinking, Anticonvulsant-convulsant effects of delta-9-tetrahydrocannabinol, in The Therapeutic Potential of Marijuana, edited by S. Cohen and R. C. Stillman (Plenum Press, New York, 1976), pp. 363–382.
D. Feeney, Marihuana and epilepsy: paradoxical anticonvulsant and convulsant effects, in Marihuana: biological effects, Advances in the Biosciences, Vol. 22/23, edited by G. O. Nahas and W. D. M. Paton (Pergamon Press, Oxford, 1979), pp. 643–657.
M. Segal, Central implantation of cannabinoids: induction of epileptiform discharges, Eur. J. Pharmacol. 27 40–45 (1974).
R. G. Pertwee, Pharmacology of cannabinoid receptor ligands, Current Med. Chem. 6, 635–664 (1999).
R. G. Pertwee and R. A. Ross, Cannabinoid receptors and their ligands, Prostaglandins, Leukotrines and Essential Fatty Acids 66 101–121 (2002).
N. Hajos and T. F. Freund, Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers, Neuropharmacology. 43, 503–510 (2002).
M. J. Wallace, R. E. Blair, K. W. Falenski, B. R. Martin, and R. J. DeLorenzo, The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy, J Pharmacol Exp Ther. 307, 129–37 (2003).
M. J. Wallace, B. R. Martin, and R. J. DeLorenzo, Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity, Eur J Pharmacol. 452, 295–301 (2002).
M. J. Wallace, J. L. Wiley, B. R. Martin, and R. J. DeLorenzo, Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects, Eur J Pharmacol. 428, 51–7 (2001).
D. M. Lambert, S. Vandevoorde, G. Diependaele, S. J. Govaerts, and A. R. Robert, Anticonvulsant activity of n-palmitoylethanolamide, a putative endocannabinoid, in mice, Epilepsia 42, 321–327 (2001).
R. A. Browning, Effects of lesions on seizures in experimental animals, in: Epilepsy and the Reticular Formation: The Role of the Reticular Core in Convulsive Seizures, edited by G. H. Fromm, C. L. Faingold, R. A. Browning, and W. M. Burnham (Alan R. Liss, Inc., New York, 1987), pp. 137–162.
A. H. Sheerin, X. Zhang, D. M. Saucier, and M. E. Corcoran, Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid, Epilepsia 45, 1–5 (2004).
A. B. Clement, E. G. Hawkins, A. H. Lichtman, and B. F. Cravatt BF, Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase, J Neurosci. 23, 3916–23, (2003).
S. Feldblum, S. and R. F. Ackermann, Increased susceptibility to hippocampal and amygdala kindling following intrahippocampal kainic acid, Exp. Neurol. 97, 255–269 (1987).
X. Zhang, K. Mackie, D. K. Hannesson, P. Mohapel, A. Wallace, J. Howland, A. Boulton, and M. E Corcoran, Effects of cannabinoid drugs on kindled seizures and status epilepticus in rats, Presented at the meeting of the Society for Neuroscience, October 1999.
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Corcoran, M.E., Saucier, D., Zhang, X., Sheerin, A., Wolfe, K. (2005). Cannabinoids and Kindling. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 6. Advances in Behavioral Biology, vol 55. Springer, Boston, MA. https://doi.org/10.1007/0-387-26144-3_33
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DOI: https://doi.org/10.1007/0-387-26144-3_33
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