Abstract
In recent years, our laboratory has been using the kindling model in a search for new drugs effective against intractable epilepsy. In this chapter, I would like to discuss (1) intractable epilepsy; (2) the limbic kindling model and how it should be used in pharmacological studies related to complex partial seizures; (3) our approach to drug discovery; (4) our experiments with deoxycorticosterone and its metabolites; and (5) our experiments with progesterone and its metabolites.
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Burnham, W.M., Lonsdale, D., Shahzamani, A., Perez-Cruz, C., Edwards, H.E. (2005). Development of New Anticonvulsants Using the Kindling Model. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 6. Advances in Behavioral Biology, vol 55. Springer, Boston, MA. https://doi.org/10.1007/0-387-26144-3_32
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