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Effects of Kindling on Spatial Memory

Characteristics and mechanisms

  • Conference paper
Kindling 6

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 55))

Abstract

Epilepsy is a chronic disorder defined by the recurrence of spontaneous seizures affecting ∼2% of the population in North America.1 There are a variety of distinct subtypes of the disorder with the most common, temporal lobe epilepsy (TLE), accounting for about 55% of all cases.1, 2 While the seizures themselves can be significantly debilitating, the clinical impact of TLE is exacerbated by the fact that about half of all sufferers exhibit serious disturbances of affect and/or memory function.3–6 At present, the mechanisms of these TLE-associated psychological impairments are unknown and, although recent studies have begun to explore the potential effectiveness of behavioral interventions,7,8 there is no treatment currently available. Consequently, these problems are often neglected clinically and have a significant adverse effect on patient quality of life.9 There is a clear need, then, for research to provide a better understanding of the bases for epilepsy-associated psychological disturbances and to develop effective treatment strategies. Clinical studies, however, are challenging because of the large number of potentially relevant but difficult to control variables. Thus, progress relies heavily on work with suitable animal models. The present chapter reviews studies on one such model — kindling in rats, and describes characteristics of spatial memory changes in this model, their relation to kindling-related variables, and potential mediating mechanisms.

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Author information

Authors and Affiliations

  1. Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, AB, Canada, S4S OA2

    Darren K. Hannesson

  2. Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5E5

    Ken Wolfe & Michael E. Corcoran

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  1. Darren K. Hannesson
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  2. Ken Wolfe
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  3. Michael E. Corcoran
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Editors and Affiliations

  1. University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Michael E. Corcoran

  2. Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA

    Solomon L. Moshé

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Hannesson, D.K., Wolfe, K., Corcoran, M.E. (2005). Effects of Kindling on Spatial Memory. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 6. Advances in Behavioral Biology, vol 55. Springer, Boston, MA. https://doi.org/10.1007/0-387-26144-3_27

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