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Kindling 6 pp 229–240Cite as

Kindling, Neurotrophins and Axon-Guidance Factors

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Part of the book series: Advances in Behavioral Biology ((ABBI,volume 55))

Abstract

Graham Goddard1 initially introduced kindling as a model for memory. Although most frequently utilized as an epilepsy model, particularly for temporal lobe epilepsy, kindling is occasionally used as a model for drug-induced plasticity, slowly developing neuropathologies other than epilepsy, and a variety of structural reorganizations of brain circuitry.2,3 Since our interest in the kindling phenomenon (and other models of epilepsy) is largely driven by our interest in neural plasticity, we have chosen to focus on kindling-induced neuronal reorganization. These kindling-induced effects may not have much relevance for epilepsy, but they are themselves interesting and potentially important phenomena and provide an excellent model for the study of mechanisms of activity-dependent neural growth.

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Authors and Affiliations

  1. Department of Psychology, McMaster University, Hamilton, Ontario, L8S 4K1

    Ronald J. Racine & Bin Xu

  2. Department of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, Ontario, L8N 3Z5

    Margaret Fahnestock

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  1. Ronald J. Racine
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  2. Margaret Fahnestock
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  3. Bin Xu
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Editors and Affiliations

  1. University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Michael E. Corcoran

  2. Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA

    Solomon L. Moshé

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Racine, R.J., Fahnestock, M., Xu, B. (2005). Kindling, Neurotrophins and Axon-Guidance Factors. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 6. Advances in Behavioral Biology, vol 55. Springer, Boston, MA. https://doi.org/10.1007/0-387-26144-3_23

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