Skip to main content
SpringerLink
Log in

Difference between Male and Female Cancer Incidence Rates: How Can It Be Explained?

  • Conference paper
Probability, Statistics and Modelling in Public Health

Summary

Age patterns of male and female cancer incidence rate do not look similar. This is because of the biologically based difference in susceptibility to cancer of different sites. This argument, however, does not clarify how age patterns of male and female cancer incidence rate must look like. The analysis of epidemiological data on cancer in different countries and in different years shows that male and female cancer incidence rates intersect around the age of female climacteric. We explain the observed pattern using the difference in ontogenetic components of aging between males and females. The explanation requires a new model of carcinogenesis, which takes this difference into account. Application to data on cancer incidence in Japan (Miyagi prefecture) illustrates the model.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arbeev, K.G., Ukraintseva, S.V., Arbeeva, L.S., Yashin, A.I.: Mathematical Models for Human Cancer Incidence Rates. Demographic Research, 12, in press, (2005)

    Google Scholar 

  2. Armitage, P., Doll, R.: The age distribution of cancer and a multistage theory of carcinogenesis. Br. J. Cancer, 8, 1–12 (1954)

    Google Scholar 

  3. IARC: Cancer Incidence in Five Continents. Volume I. International Agency for Research on Cancer, Lyon (1965)

    Google Scholar 

  4. IARC: Cancer Incidence in Five Continents. Volume II. International Agency for Research on Cancer, Lyon (1970)

    Google Scholar 

  5. IARC: Cancer Incidence in Five Continents. Volume III. IARC Sci Publ, 15 (1976)

    Google Scholar 

  6. IARC: Cancer Incidence in Five Continents. Volume IV. IARC Sci Publ, 42 (1982)

    Google Scholar 

  7. IARC: Cancer Incidence in Five Continents. Volume V. IARC Sci Publ, 88 (1987)

    Google Scholar 

  8. IARC: Cancer Incidence in Five Continents. Volume VI. IARC Sci Publ, 120 (1992)

    Google Scholar 

  9. IARC: Cancer Incidence in Five Continents. Volume VII. IARC Sci Publ, 143 (1997)

    Google Scholar 

  10. Moolgavkar, S.H., Luebeck, E.G.: Two-event model for carcinogenesis: biological, mathematical and statistical considerations. Risk Anal., 10, 323–341 (1990)

    Google Scholar 

  11. Sankaranarayanan, K., Chakraborty, R., Boerwinkle, E.: Ionizing radiation and genetic risks — VI. Chronic multifactorial diseases: a review of epidemiological and genetical aspects of coronary heart disease, essential hypertension and diabetes mellitus. Mutat. Res., 436, 21–57 (1999)

    Google Scholar 

  12. Ukraintseva, S.V.: Genetic-Epidemiological Analysis of Predisposition to Asthma. Ph.D. Thesis, Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow (1998)

    Google Scholar 

  13. Ukraintseva, S.V.: On the role of age in asthma morbidity. Clinical Gerontology, 6, 29–33 (2000)

    Google Scholar 

  14. Ukraintseva, S.V., Sergeev, A.: Analysis of genetic heterogeneity of bronchial asthma as related to the age of onset. Russian Journal of Genetics, 36, 201–205 (2000)

    Google Scholar 

  15. Ukraintseva, S.V., Yashin, A.I.: How individual aging may influence human morbidity and mortality patterns. Mech. Aging and Dev., 122, 1447–1460 (2001)

    Google Scholar 

  16. Yakovlev, A.Yu., Asselain, B., Bardou, V.-J., Fourquet, A., Hoang, T., Rochefodiere, A., Tsodikov, A.D.: A simple stochastic model of tumor recurrence and its application to data on pre-menopausal breast cancer. In: Asselain, B., Boniface, M., Duby, C., Lopez, C., Masson, J.P., Tranchefort, J., (ed) Biometrie et Analyse de Donnees Spatio-Temporelles, 12. Societe Francaise de Biometrie. ENSA, Rennes (1993)

    Google Scholar 

  17. Yakovlev, A.Yu., Tsodikov, A.D., Bass, L.: A stochastic model of hormesis. Math. Biosci., 116, 197–219 (1993)

    Article  Google Scholar 

  18. Yakovlev, A.Yu., Tsodikov, A.D.: Stochastic Models of Tumor Latency and their Bio-statistical Applications. World Scientific, Singapore (1996)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Demographic Studies, Duke University, 2117 Campus Drive, Box 90408, Durham, NC, 27708-0408, USA

    Konstantin G. Arbeev, Svetlana V. Ukraintseva & Anatoli I. Yashin

  2. Ulyanovsk State University, Leo Tolstoi St. 42, 432700, Ulyanovsk, Russia

    Lyubov S. Arbeeva

Authors
  1. Konstantin G. Arbeev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Svetlana V. Ukraintseva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lyubov S. Arbeeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anatoli I. Yashin
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Université Victor Segalin Bordeaux 2, France

    Mikhail Nikulin  & Daniel Commenges  & 

  2. V. Steklov Mathematical Institute, Saint Petersburg, Russia

    Mikhail Nikulin

  3. Université René Descartes, Paris, France

    Catherine Huber

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer Science+Business Media, Inc.

About this paper

Cite this paper

Arbeev, K.G., Ukraintseva, S.V., Arbeeva, L.S., Yashin, A.I. (2006). Difference between Male and Female Cancer Incidence Rates: How Can It Be Explained?. In: Nikulin, M., Commenges, D., Huber, C. (eds) Probability, Statistics and Modelling in Public Health. Springer, Boston, MA. https://doi.org/10.1007/0-387-26023-4_2

Download citation

Publish with us

Policies and ethics

Search

Navigation