Skip to main content
SpringerLink
Log in

Investigation of Network Phenomena in Hippocampal Slices Using Multi-Electrode Recording Arrays

  • Chapter
Book cover Advances in Network Electrophysiology

18.4 Concluding Remarks

Tools that are capable of sampling electrophysiological signals across spatially distributed brain networks, such as multi-electrode recording arrays, will likely be used increasingly often as more and more researchers strive to bridge the gap between synaptic interactions and computations across neuronal ensembles. This chapter pointed out specific studies in which the increased dimensions of information provided by multi-electrode recording allowed spatiotemporal patterns to be observed that would have been difficult to discern using conventional recording methods. Although technical difficulties can complicate the use of multi-electrode recording, they can largely be overcome through sophisticated analysis techniques. As computational methods and the electronic devices themselves are advanced, further insights into the complex operations of brain networks are to be expected.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Behrends, J.C. and ten Bruggencate, G. (1993). Cholinergic modulation of synaptic inhibition in the guinea pig hippocampus in vitro: Excitation of GABAergic interneurons and inhibition of GABA-release. J. Neurophysiol. 69: 626–629.

    PubMed  CAS  Google Scholar 

  • Benson, D.M., Blitzer, R.D., and Landau, E.M. (1988). An analysis of the depolarization produced in guinea-pig hippocampus by cholinergic receptor stimulation. J. Physiol. 404: 479–496.

    PubMed  CAS  Google Scholar 

  • Boddeke, H., Best, R., and Boeijinga, P.H. (1997). Synchronous 20 Hz rhythmic activity in hippocampal networks induced by activation of metabotropic glutamate receptors in vitro. Neuroscience 76: 653–658.

    PubMed  CAS  Google Scholar 

  • Bramham, C.R. and Srebro, B. (1989). Synaptic plasticity in the hippocampus is modulated by behavioral state. Brain Res. 493: 74–86.

    Article  PubMed  CAS  Google Scholar 

  • Charpak, S., Pare, D., and Llinas, R. (1995). The entorhinal cortex entrains fast CA1 hippocampal oscillations in the anaesthetized guinea-pig—Role of the monosynaptic component of the perforant path. Euro. J. Neurosci. 7: 1548–1557.

    Article  CAS  Google Scholar 

  • Chrobak, J.J. and Buzsaki, G. (1998). Gamma oscillations in the entorhinal cortex of the freely behaving rat. J. Neurosci. 18: 388–398.

    PubMed  CAS  Google Scholar 

  • Colgin, L.L., Kramar, E.A., Gall, C.M., and Lynch, G. (2003). Septal modulation of excitatory transmission in hippocampus. J. Neurophysiol. 90: 2358–2366.

    Article  PubMed  Google Scholar 

  • Csicsvari, J., Hirase, H., Czurko, A., Mamiya, A., and Buzsaki, G. (1999). Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat. J. Neurosci. 19: 274–287.

    PubMed  CAS  Google Scholar 

  • Fellous, J.M. and Sejnowski, T.J. (2000). Cholinergic induction of oscillations in the hippocampal slice in the slow (0.5–2 Hz), theta (5–12 Hz), and gamma (35–70 Hz) bands. Hippocampus 10: 187–197.

    Article  PubMed  CAS  Google Scholar 

  • Fisahn, A., Pike, F.G., Buhl, E.H., and Paulsen, O. (1998). Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro. Nature 394: 186–189.

    Article  PubMed  CAS  Google Scholar 

  • Foster, T.C. and Deadwyler, S.A. (1992). Acetylcholine modulates averaged sensory evoked responses and perforant path evoked field potentials in the rat dentate gyrus. Brain Res. 587: 95–101.

    Article  PubMed  CAS  Google Scholar 

  • Freeman, W. (1975). Mass Action in the Nervous System, Academic Press, New York.

    Google Scholar 

  • Gray, C.M. and Singer, W. (1989). Stimulus-specific neuronal oscillations in orientation columns of cat visual cortex. Proc. Natl. Acad. Sci. U. S. A. 86: 1698–1702.

    Article  PubMed  CAS  Google Scholar 

  • Haberly, L.B. and Shepherd, G.M. (1973). Current-density analysis of summed evoked potentials in opossum prepyriform cortex. J. Neurophysiol. 36: 789–802.

    PubMed  CAS  Google Scholar 

  • Hajos, N., Papp, E.C., Acsady, L., Levey, A.I., and Freund, T.F. (1998). Distinct interneuron types express m2 muscarinic receptor immunoreactivity on their dendrites or axon terminals in the hippocampus. Neuroscience 82: 355–376.

    Article  PubMed  CAS  Google Scholar 

  • Hasselmo, M.E. and Fehlau, B.P. (2001). Differences in time course of ACh and GABA modulation of excitatory synaptic potentials in slices of rat hippocampus. J. Neurophysiol. 86:1792–1802.

    PubMed  CAS  Google Scholar 

  • Hasselmo, M.E., Schnell, E., and Barkai, E. (1995). Dynamics of learning and recall at excitatory recurrent synapses and cholinergic modulation in rat hippocampal region Ca3. J. Neurosci. 15: 5249–5262.

    PubMed  CAS  Google Scholar 

  • Hjorth-Simonsen, A. (1973). Some intrinsic connections of the hippocampus in the rat: An experimental analysis. J. Comp. Neurol. 147: 145–161.

    Article  PubMed  CAS  Google Scholar 

  • Huerta, P.T. and Lisman, J.E. (1993). Heightened synaptic plasticity of hippocampal CA1 neurons during a cholinergically induced rhythmic state. Nature 364: 723–725.

    Article  PubMed  CAS  Google Scholar 

  • Huerta, P.T. and Lisman, J.E. (1995). Bidirectional synaptic plasticity induced by a single burst during cholinergic theta oscillation in CA1 in vitro. Neuron 15: 1053–1063.

    Article  PubMed  CAS  Google Scholar 

  • Hyman, J.M., Wyble, B.P., Goyal, V., Rossi, C.A., and Hasselmo, M.E. (2003). Stimulation in hippocampal regionCA1 in behaving rats yields long-term potentiation when delivered to the peak of theta and long-term depression when delivered to the trough. J. Neurosci. 23: 11725–11731.

    PubMed  CAS  Google Scholar 

  • Iijima, T., Witter, M.P., Ichikawa, M., Tominaga, T., Kajiwara, R., and Matsumoto, G. (1996). Entorhinal-hippocampal interactions revealed by real-time imaging. Science 272: 1176–1179.

    PubMed  CAS  Google Scholar 

  • Ishizuka, N., Weber, J., and Amaral, D.G. (1990). Organization of intrahippocampal projections originating from CA3 pyramidal cells in the rat. J. Comp. Neurol. 295: 580–623.

    Article  PubMed  CAS  Google Scholar 

  • Jensen, O. and Tesche, C.D. (2002). Frontal theta activity in humans increases with memory load in a working memory task. Eur. J. Neurosci. 15: 1395–1399.

    Article  PubMed  Google Scholar 

  • Kahle, J.S. and Cotman, C.W. (1989). Carbachol depresses synaptic responses in the medial but not the lateral perforant path. Brain Res. 482: 159–163.

    Article  PubMed  CAS  Google Scholar 

  • Konopacki, J., Maciver, M.B., Bland, B.H., and Roth, S.H. (1987). Theta in hippocampal slices: Relation to synaptic responses of dentate neurons. Brain Res. Bull. 18: 25–27.

    Article  PubMed  CAS  Google Scholar 

  • Kopell, N., Ermentrout, G.B., Whittington, M.A., and Traub, R.D. (2000). Gamma rhythms and beta rhythms have different synchronization properties. Proc. Natl. Acad. Sci. U. S. A. 97: 1867–1872.

    Article  PubMed  CAS  Google Scholar 

  • Landfield, P.W., McGaugh, J.L., and Tusa, R.J. (1972). Theta rhythm: A temporal correlate of memory storage processes in the rat. Science 175: 87–89.

    Article  PubMed  CAS  Google Scholar 

  • Larson, J. and Lynch, G. (1986). Induction of synaptic potentiation in hippocampus by patterned stimulation involves two events. Science 232: 985–988.

    Article  PubMed  CAS  Google Scholar 

  • Larson, J., Wong, D., and Lynch, G. (1986). Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation. Brain Res. 368: 347–350.

    Article  PubMed  CAS  Google Scholar 

  • Leung, L.W., Lopes da Silva, F.H., and Wadman, W.J. (1982). Spectral characteristics of the hippocampal EEG in the freely moving rat. Electroencephalog. Clin. Neurophysiol. 54: 203–219.

    Article  CAS  Google Scholar 

  • Leung, L.S. (1992). Fast (beta) rhythms in the hippocampus: A review. Hippocampus 2: 93–98.

    Article  PubMed  CAS  Google Scholar 

  • Leung, L.S. (1998). Generation of theta and gamma rhythms in the hippocampus. Neurosci. Biobehav. Rev. 22: 275–290.

    Article  PubMed  CAS  Google Scholar 

  • Levey, A.I., Edmunds, S.M., Koliatsos, V., Wiley, R.G., and Heilman, C.J. (1995). Expression of m1–m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation. J. Neurosci. 15: 4077–4092.

    PubMed  CAS  Google Scholar 

  • Lisman, J., Jensen, O., and Kahana, M. (2001). Toward a physiologic explanation of behavioral data on human memory—The role of theta-gamma oscillations and NMDAR-dependent LTP. In: Holscher, C., ed., Neuronal Mechanisms of Memory Formation: Concepts of Long-Term Potentiation and Beyond, Cambridge University Press, Cambridge, pp.195–223.

    Google Scholar 

  • Madison, D.V., Lancaster, B., and Nicoll, R.A. (1987). Voltage clamp analysis of cholinergic action in the hippocampus. J. Neurosci. 7: 733–741.

    PubMed  CAS  Google Scholar 

  • M’Harzi, M. and Jarrard, L.E. (1992). Effects of medial and lateral septal lesions on acquisition of a place and cue radial maze task. Behav. Brain Res. 49: 159–165.

    PubMed  CAS  Google Scholar 

  • Mizumori, S.J., Perez, G.M., Alvarado, M.C., Barnes, C.A., and McNaughton, B.L. (1990). Reversible inactivation of the medial septum differentially affects two forms of learning in rats. Brain Res. 528: 12–20.

    Article  PubMed  CAS  Google Scholar 

  • Nakajima, Y., Nakajima, S., Leonard, R.J., and Yamaguchi, K. (1986). Acetylcholine raises excitability by inhibiting the fast transient potassium current in cultured hippocampal neurons. Proc. Natl. Acad. Sci. U. S. A. 83: 3022–3026.

    Article  PubMed  CAS  Google Scholar 

  • Nicholson, C. (1973). Theoretical analysis of field potentials in anisotropic ensembles of neuronal elements. IEEE Trans. Biomed. Eng. 20: 278–288.

    PubMed  CAS  Google Scholar 

  • Nicholson, C. and Freeman, J.A. (1975). Theory of current source-density analysis and determination of conductivity tensor for anuran cerebellum. J. Neurophysiol. 38: 356–368.

    PubMed  CAS  Google Scholar 

  • Nicholson, C. and Llinas R. (1975). Real time current source-density analysis using multi-electrode array in cat cerebellum. Brain Res. 100: 418–424.

    Article  PubMed  CAS  Google Scholar 

  • Pavlides, C., Greenstein, Y.J., Grudman, M., and Winson, J. (1988). Long-term potentiation in the dentate gyrus is induced preferentially on the positive phase of theta-rhythm. Brain Res. 439: 383–387.

    Article  PubMed  CAS  Google Scholar 

  • Pitler, T.A. and Alger, B.E. (1992). Cholinergic excitation of GABAergic interneurons in the rat hippocampal slice. J. Physiol. 450: 127–142.

    PubMed  CAS  Google Scholar 

  • Qian, J. and Saggau P. (1997). Presynaptic inhibition of synaptic transmission in the rat hippocampus by activation of muscarinic receptors—Involvement of presynaptic calcium influx. Brit. J. Pharmacol. 122: 511–519.

    Article  CAS  Google Scholar 

  • Sheridan, R.D. and Sutor, B. (1990). Presynaptic M1 muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in the hippocampus in vitro. Neurosci. Lett. 108: 273–278.

    Article  PubMed  CAS  Google Scholar 

  • Shimono, K., Brucher, F., Granger, R., Lynch, G., and Taketani, M. (2000). Origins and distribution of cholinergically induced beta rhythms in hippocampal slices. J. Neurosci. 20: 8462–8473.

    PubMed  CAS  Google Scholar 

  • Shimono, K., Kubota, D., Brucher, F., Taketani, M., and Lynch, G. (2002). Asymmetrical distribution of the Schaffer projections within the apical dendrites of hippocampal field CA1. Brain Res. 950: 279–287.

    Article  PubMed  CAS  Google Scholar 

  • Staubli, U. and Lynch, G. (1987). Stable hippocampal long-term potentiation elicited by ‘theta’ pattern stimulation. Brain Res. 435: 227–234.

    Article  PubMed  CAS  Google Scholar 

  • Swanson, L.W., Wyss, J.M., and Cowan, W.M. (1978). An autoradiographic study of the organization of intrahippocampal association pathways in the rat. J. Comp. Neurol. 181: 681–715.

    Article  PubMed  CAS  Google Scholar 

  • Tesche, C.D. and Karhu, J. (2000). Theta oscillations index human hippocampal activation during a working memory task. Proc. Natl. Acad. Sci. U. S. A. 97: 919–924.

    Article  PubMed  CAS  Google Scholar 

  • Traub, R.D., Whittington, M.A., Buhl, E.H., Jefferys, J.G.R., and Faulkner, H.J. (1999). On the mechanism of the gamma-> beta frequency shift in neuronal oscillations induced in rat hippocampal slices by tetanic stimulation. J. Neurosci. 19: 1088–1105.

    PubMed  CAS  Google Scholar 

  • Valentino, R.J. and Dingledine, R. (1981). Presynaptic inhibitory effect of acetylcholine in the hippocampus. J. Neurosci. 1: 784–792.

    PubMed  CAS  Google Scholar 

  • van der Linden, S., Panzica, F., and de Curtis, M. (1999). Carbachol induces fast oscillations in the medial but not in the lateral entorhinal cortex of the isolated guinea pig brain. J. Neurophysiol. 82: 2441–2450.

    Google Scholar 

  • Vertes, R.P. and Kocsis, B. (1997). Brainstem-diencephalo-septohippocampal systems controlling the theta rhythm of the hippocampus. Neuroscience 81: 893–926.

    Article  PubMed  CAS  Google Scholar 

  • Whittington, M.A., Traub, R.D., and Jefferys, J.G.R. (1995). Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation. Nature 373: 612–615.

    Article  PubMed  CAS  Google Scholar 

  • Williams, J.H. and Kauer, J.A. (1997). Properties of carbachol-induced oscillatory activity in rat hippocampus. J. Neurophysiol. 78: 2631–2640.

    PubMed  CAS  Google Scholar 

  • Winson, J. (1978). Loss of hippocampal theta rhythm results in spatial memory deficit in the rat. Science 201: 160–163.

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto, C. and Kawai, N. (1967). Presynaptic action of acetylcholine in thin sections from the guinea pig dentate gyrus in vitro. Exp. Neurol. 19: 176–187.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry and Human Behavior, University of California, Irvine, USA

    Laura Lee Colgin

Authors
  1. Laura Lee Colgin
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Panasonic Research and Development, Company of America, Cypress, CA, 92630, USA

    Makoto Taketani

  2. Department of Biological Sciences, University of Southern California, Los Angeles, Los Angeles, CA, USA

    Michel Baudry

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer Science+Business Media, Inc.

About this chapter

Cite this chapter

Colgin, L.L. (2006). Investigation of Network Phenomena in Hippocampal Slices Using Multi-Electrode Recording Arrays. In: Taketani, M., Baudry, M. (eds) Advances in Network Electrophysiology. Springer, Boston, MA . https://doi.org/10.1007/0-387-25858-2_18

Download citation

Publish with us

Policies and ethics

Search

Navigation