Skip to main content

Applications of Multi-Electrode Array System in Drug Discovery Using Acute and Cultured Hippocampal Slices

  • Chapter
Advances in Network Electrophysiology

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Assaf, S.Y. and Miller, J.J. (1978) The role of a raphe serotonin system in the control of septal unit activity and hippocampal desynchronization. Neuroscience 3: 539–550.

    Article  PubMed  CAS  Google Scholar 

  • Azmitia, E.C. and Segal, M. (1978). An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179: 641–667.

    Article  PubMed  CAS  Google Scholar 

  • Bojarski, A.J., Mokrosz, M.J., Minol, S.C., Koziol, A., Wesolowska, A., Tatarczynska, E., Klodzinska, A., and Chojnacka-Wojcik, E. (2002). The influence of substitution at aromatic part of 1,2,3,4-tetrahydroisoquinoline on in vitro and in vivo 5-HT(1A)/5-HT(2A) receptor activities of its 1-adamantoyloaminoalkyl derivatives. Bioorg. Med. Chem. 10: 87–95.

    Article  PubMed  CAS  Google Scholar 

  • Fell, J., Klaver, P., Lehnertz, K., Grunwald, T., Schaller, C., Elger, C.E., and Fernandez, G. (2001). Human memory formation is accompanied by rhinal-hippocampal coupling and decoupling. Nat. Neurosci. 4: 1259–1264.

    Article  PubMed  CAS  Google Scholar 

  • Fellous, J.M. and Sejnowski, T.J. (2000). Cholinergic induction of oscillations in the hippocampal slice in the slow (0.5–2 Hz), theta (5–12 Hz), and gamma (35–70 Hz) bands. Hippocampus 10: 187–197.

    Article  PubMed  CAS  Google Scholar 

  • Fisahn, A., Pike, F.G., Buhl, E.H., and Paulsen, O. (1998). Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro. Nature 394: 186–189.

    Article  PubMed  CAS  Google Scholar 

  • Fix, A.S., Horn, J.W., Wightman, K.A., Johnson, C.A., Long, G.G., Storts, R.W., Farber, N., Wozniak, D.F., and Olney, J.W. (1993). Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (dizocilpine maleate): A light and electron microscopic evaluation of the rat retrosplenial cortex. Exp. Neurol. 123: 204–215.

    Article  PubMed  CAS  Google Scholar 

  • Krause, M. and Jia, Y. (2005). Serotonergic modulation of carbachol-induced rhythmic activity in hippocampal slices. Neuropharmacology. 2005 Mar; 48(3): 381–390. Epub 2005 Jan 25.

    Article  PubMed  CAS  Google Scholar 

  • Kristensen, B.W., Noraberg, J., and Zimmer, J. (2001). Comparison of exitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures. Brain Res. 917: 21–44.

    Article  PubMed  CAS  Google Scholar 

  • Llinas, R. and Ribary, U. (1993). Coherent 40-Hz oscillation characterizes dream state in humans. Proc. Natl. Acad. Sci. U. S. A. 90: 2078–2081.

    Article  PubMed  CAS  Google Scholar 

  • Maloney, K.J., Cape, E.G., Gotman, J., Jones, B.E. (1997). High-frequency gamma electroencephalogram activity in association with sleep-wake states and spontaneous behaviors in the rat. Neuroscience 76: 541–555.

    Article  PubMed  CAS  Google Scholar 

  • McBain, C.J. and Fisahn, A. (2001). Interneurons unbound. Nat. Rev. Neurosci. 2: 11–23.

    Article  PubMed  CAS  Google Scholar 

  • McQuade, R. and Sharp, T. (1997). Functional mapping of dorsal and median raphe 5-hydroxytryptamine pathways in forebrain of the rat using microdialysis. J. Neurochem. 69: 791–796.

    Article  PubMed  CAS  Google Scholar 

  • Mokrosz, M.J., Bojarski, A.J., Duszynska, B., Tatarczynska, E., Klodzinska, A., Deren-Wesolek, A., Charakchieva-Minol, S., and Chojnacka-Wojcik, E. (1999). 1,2,3,4-tetrahydroisoquinoline derivatives: A new class of 5-HT1A receptor ligands. Bioorg. Med. Chem. 7: 287–295.

    Article  PubMed  CAS  Google Scholar 

  • Moore, R.Y. and Halaris, A.E. (1975). Hippocampal innervation by serotonin neurons of the midbrain raphe in the rat. J. Comp. Neurol. 164: 171–183.

    Article  PubMed  CAS  Google Scholar 

  • Nitz, D.A. and McNaughton, B.L. (1999). Hippocampal EEG and unit activity responses to modulation of serotonergic median raphe neurons in the freely behaving rat. Learn. Mem. 6: 153–167.

    PubMed  CAS  Google Scholar 

  • Oleskevich, S. and Descarries, L. (1990). Quantified distribution of the serotonin innervation in adult rat hippocampus. Neuroscience 34: 19–33.

    Article  PubMed  CAS  Google Scholar 

  • Parsons, C.G., Danysz, W., and Quack, G. (1999). Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist-A review of preclinical data. Neuropharmacology 38: 735–767.

    Article  PubMed  CAS  Google Scholar 

  • Peterson, C., Neal, J.H., and Cotman, C.W. (1989). Development of N-methyl-D-aspartate excitotoxity in cultured hippocampal neurons. Dev. Brain Res. 48: 187–195.

    Article  CAS  Google Scholar 

  • Pringle, A.K., Self, J., Eshak, M., and Iannotti, F. (2000). Reducing conditions significantly attenuate the neuroprotective efficacy of competitive, but not other NMDA receptor antagonists in vitro. Eur. J. Neurosci. 12: 3833–3842.

    Article  PubMed  CAS  Google Scholar 

  • Sharif, N.A., Drace, C.D., Williams, G.W., and Crider, J.Y. (2004). Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation. J. Pharm. Pharmacol. 56: 1267–1274.

    Article  PubMed  CAS  Google Scholar 

  • Shimono, K., Brucher, F., Granger, R., Lynch, G., and Taketani, M. (2000). Origins and distribution of cholinergically induced beta rhythms in hippocampal slices. J. Neurosci. 20: 8462–8473.

    PubMed  CAS  Google Scholar 

  • Singer, W. (1999). Neuronal synchrony: A versatile code for the definition of relations? Neuron 24: 49–65, 111–125.

    Article  PubMed  CAS  Google Scholar 

  • Sirvio, J., Larson, J., Quach, C.N., Rogers, G.A., and Lynch, G. (1996). Effects of pharmacologically facilitating glutamatergic transmission in the trisynaptic intrahippocampal circuit. Neuroscience. 74: 1025–1035.

    PubMed  CAS  Google Scholar 

  • Staubli, U. and Lynch, G. (1987). Stable hippocampal long-term potentiation elicited by ‘theta’ pattern stimulation. Brain Res. 435: 227–234.

    Article  PubMed  CAS  Google Scholar 

  • Stoppini, L., Buchs, P.A., and Muller, D. (1991). A simple method for organotypic cultures of nervous tissue. J. Neurosci. Meth. 37: 173–182.

    Article  CAS  Google Scholar 

  • Traub, R.D., Bibbig, A., Fisahn, A., LeBeau, F.E., Whittington, M.A., and Buhl, E.H. (2000). A model of gamma-frequency network oscillations induced in the rat CA3 region by carbachol in vitro. Eur. J. Neurosci. 12: 4093–4106.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer Science+Business Media, Inc.

About this chapter

Cite this chapter

Baudry, M., Taketani, M., Krause, M. (2006). Applications of Multi-Electrode Array System in Drug Discovery Using Acute and Cultured Hippocampal Slices. In: Taketani, M., Baudry, M. (eds) Advances in Network Electrophysiology. Springer, Boston, MA . https://doi.org/10.1007/0-387-25858-2_15

Download citation

Publish with us

Policies and ethics