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Drugs of Abuse, AIDS, and the FIV Model

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In vivo Models of HIV Disease and Control

Part of the book series: Infectious Diseases and Pathogenesis ((IAPA))

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Abstract

Drug abuse is an important route of exposure to human immunodeficiency virus-1 (HIV-1). However, the role that drugs of abuse play in lentivirus disease progression remains unclear. There is a pressing need for appropriate animal models to examine the role of drugs of abuse on lentivirus disease progression. The feline immunodeficiency virus (FIV)/cat model is a legitimate system for the study of lentivirus-induced disease. Not only does FIV produce a disease that is very similar to human acquired immune deficiency syndrome (AIDS), but it is also similar to HIV-1 at both the molecular and biochemical levels. In this chapter, we will concentrate on the interactions of opiates and methamphetamine with lentivirus-induced disease, emphasizing the use of the FIV model.

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Authors and Affiliations

  1. College of Veterinary Medicine, Western University of Health Sciences, 309 East Second Street, Pomona, CA, 91766-1854

    Margaret C. Barr, Maria Pia Testa & Tom R. Phillips

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  1. Margaret C. Barr
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  2. Maria Pia Testa
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Editors and Affiliations

  1. Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, FL, 33612, USA

    Herman Friedman  & Steven Specter  & 

  2. Department of Experimental Pathology and Retrovirus Center, University of Pisa, Via S. Zeno, 37, Pisa, I-56127, Italy

    Mauro Bendinelli

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Barr, M.C., Testa, M.P., Phillips, T.R. (2006). Drugs of Abuse, AIDS, and the FIV Model. In: Friedman, H., Specter, S., Bendinelli, M. (eds) In vivo Models of HIV Disease and Control. Infectious Diseases and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/0-387-25741-1_9

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