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SCID Mice Transplanted With Human Cells as Small Animal Models in AIDS Research

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In vivo Models of HIV Disease and Control

Part of the book series: Infectious Diseases and Pathogenesis ((IAPA))

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Abstract

The progress in AIDS research has been hampered by the lack of a small and practical animal model susceptible to HIV infection, suitable for a rapid testing of antiviral compounds and vaccines. Over the past 20 years, different attempts have been made to develop various models for AIDS in mice. An ensemble of studies carried out in several laboratories during the past decade by using SCID mice transplanted with human cells and infected with HIV have revealed that these chimeric human-mouse models can indeed represent valuable animal systems for addressing a variety of important issues in AIDS research.

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Authors and Affiliations

  1. Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy, 00161

    Caterina Lapenta, Stefano M. Santini, Massimo Spada & Filippo Belardelli

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  1. Caterina Lapenta
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  2. Stefano M. Santini
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  3. Massimo Spada
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  4. Filippo Belardelli
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Editors and Affiliations

  1. Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, FL, 33612, USA

    Herman Friedman  & Steven Specter  & 

  2. Department of Experimental Pathology and Retrovirus Center, University of Pisa, Via S. Zeno, 37, Pisa, I-56127, Italy

    Mauro Bendinelli

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Lapenta, C., Santini, S.M., Spada, M., Belardelli, F. (2006). SCID Mice Transplanted With Human Cells as Small Animal Models in AIDS Research. In: Friedman, H., Specter, S., Bendinelli, M. (eds) In vivo Models of HIV Disease and Control. Infectious Diseases and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/0-387-25741-1_4

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