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Effects Of Hypocretin/Orexin on the Thalamocortical Activating System

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Hypocretins

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7. Conclusions

Hypocretin can excite the thalamocortical arousal pathway at two levels. It can selectively depolarize neurons in the midline-intralaminar nuclei of the thalamus, but it can also directly excite their axon terminals within prefrontal cortex. Since these two regions appear to receive projections from different populations of hypocretin neurons, further understanding of what governs hypocretin release in these two areas will yield greater insight into thalamocortical involvement in arousal and attention.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06508

    Evelyn K. Lambe

  2. Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT, 06508

    George K. Aghajanian

Authors
  1. Evelyn K. Lambe
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  2. George K. Aghajanian
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Editors and Affiliations

  1. The Scripps Research Institute, La Jolla, CA, 92037, USA

    Luis de Lecea  & J. Gregor Sutcliffe  & 

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Lambe, E.K., Aghajanian, G.K. (2005). Effects Of Hypocretin/Orexin on the Thalamocortical Activating System. In: de Lecea, L., Sutcliffe, J.G. (eds) Hypocretins. Springer, Boston, MA. https://doi.org/10.1007/0-387-25446-3_12

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