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Immune Surveillance against Dermatophyte Infection

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Fungal Immunology

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References

  • Baker, B.S., Ovigne, J.M., Powles, A.V., Corcoran, S., and Fry, L. (2003). Normal keratinocytes express toll-like receptors (TLRs) 1, 2 and 5: Modulation of TLR expression in chronic plaque psoriasis. Br. J. Dermatol. 148: 670–679.

    Article  CAS  PubMed  Google Scholar 

  • Banchereau, J. and Steinman, R.M. (1998). Dendritic cells and the control of immunity. Nature 392: 245–252.

    Article  CAS  PubMed  Google Scholar 

  • Barnes, P.J. and Karin, M. (1997). Nuclear factor-κB—a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336: 1066–1071.

    Article  CAS  PubMed  Google Scholar 

  • Berk, S.H., Penneys, N.S., and Weinstein, G.D. (1976). Epidermal activity in annular dermatophytosis. Arch. Dermatol. 112: 485–488.

    Article  CAS  PubMed  Google Scholar 

  • Blake, J.S., Cabrera, R.M., Dahl, M.V., Herron, M.J., and Nelson, R.D. (1991a). Comparison of the immunoinhibitory properties of cell wall mannan glycoproteins from Trichophyton rubrum and Microsporum canis. J. Invest. Dermatol. 96: 601.

    Article  Google Scholar 

  • Blake, J.S., Dahl, M.V., Herron, M.J., and Nelson, R.D. (1991b). An immunoinhibitory cell wall glycoprotein (mannan) from Trichophyton rubrum. J. Invest. Dermatol. 96: 657–661.

    Article  CAS  PubMed  Google Scholar 

  • Braathen, L.R. and Kaaman, T. (1983). Human epidermal Langerhans cells induce cellular immune response to trichophytin in dermatophytosis. Br. J. Dermatol. 109: 295–300.

    CAS  PubMed  Google Scholar 

  • Brasch, J. and Sterry, W. (1992). Immunophenotypical characterization of inflammatory cellular infiltrates in tinea. Acta Derm. Venereol. (Stockh.) 72: 345–347.

    CAS  Google Scholar 

  • Brasch, J., Martens, H., and Sterry, W. (1993). Langerhans cell accumulation in chronic tinea pedis and pityriasis versicolor. Clin. Exp. Dermatol. 18: 329–332.

    CAS  PubMed  Google Scholar 

  • Cabrera, R.M., Blake, J.S., Dahl, M.V., Herron, M.J., and Nelson, R.D. (1991). Inhibition of keratinocyte proliferation by a mannan glycoprotein isolated from Trichophyton rubrum. J. Invest. Dermatol. 96: 616.

    Google Scholar 

  • Calderon, R.A. (1989). Immunoregulation of dermatophytosis. Crit. Rev. Microbiol. 16: 338–368.

    Google Scholar 

  • Calderon, R.A. and Hay, R.J. (1987). Fungicidal activity of human neutrophils and monocytes on dermatophytic fungi, Trichophyton quinckeanum and Trichophyton rubrum. Immunology 61: 289–295.

    CAS  PubMed  Google Scholar 

  • Dahl, M.V. (1987). Immunological resistance to dermatophyte infections. Adv. Dermatol. 2: 305–320.

    CAS  PubMed  Google Scholar 

  • Dahl, M.V. (1993). Suppression of immunity and inflammation by products produced by dermatophytes. J. Am. Acad. Dermatol. 28: S19–S23.

    CAS  PubMed  Google Scholar 

  • Dahl, M.V. (1994). Dermatophytosis and the immune response. J. Am. Acad. Dermatol. 31: S34–S41.

    CAS  PubMed  Google Scholar 

  • Davies, R.R. and Zaini, F. (1984). Trichophyton rubrum and the chemotaxis of polymorphonuclear leucocytes. Sabouraudia 22: 65–71.

    CAS  PubMed  Google Scholar 

  • Emtestam, L., Kaaman, T., Hovmark, A., and Asbrink, E. (1985). An immunohistochemical staining of epidermal Langerhans cells in tinea cruris. Acta Derm. Venereol. (Stockh.) 65: 240–243.

    CAS  Google Scholar 

  • Fong, T.A.T. and Mosmann, T.R. (1989). The role of IFN-γ in delayed type hypersensitivity mediated by Th1 clones. J. Immunol. 143: 2887–2893.

    CAS  PubMed  Google Scholar 

  • Fuhlbrigge, R.C., Kieffer, J.D., Armerding, D., and Kupper, T.S. (1997). Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 389: 978–981.

    CAS  PubMed  Google Scholar 

  • Gallo, R.L., Murakami, M., Ohtake, T., and Zaiou, M. (2002). Biology and clinical relevance of naturally occurring antimicrobial peptides. J. Allergy Clin. Immunol. 110: 823–831.

    Article  CAS  PubMed  Google Scholar 

  • Grando, S.A., Hostager, B.S., Herron, M.J., Dahl, M.V., and Nelson, R.D. (1992). Binding of Trichophyton rubrum mannan to human monocytes in vitro. J. Invest. Dermatol. 98: 876–880.

    Article  CAS  PubMed  Google Scholar 

  • Grappel, S.F. and Blank, F. (1972). Role of keratinases in dermatophytosis. I. Immune responses of guinea pigs infected with Trichophyton mentagrophytes and guinea pigs immunized with keratinases. Dermatologica 145: 245–255.

    CAS  PubMed  Google Scholar 

  • Grappel, S.F., Bishop, C.T., and Blank, F. (1974). Immunology of dermatophytes and dermatophytosis. Bacteriol. Rev. 38: 222–250.

    CAS  PubMed  Google Scholar 

  • Gregurek-Novak, T., Rabatic, S., and Silobrcic, V. (1993). Defective phagocytosis in chronic trichophytosis. J. Med. Vet. Mycol. 31: 115–120.

    CAS  PubMed  Google Scholar 

  • Green, F., Weber, J.K., and Balish, E. (1983). The thymus dependency of acquired resistance to Trichophyton mentagrophytes dermatophytosis in rats. J. Invest. Dermatol. 81: 31–38.

    PubMed  Google Scholar 

  • Harder, J., Bartels, J., Christophers, E., and Schroder, J.M. (1997). A peptide antibiotic from human skin. Nature 387: 861.

    Article  CAS  PubMed  Google Scholar 

  • Hay, R.J. and Brostoff, J. (1977). Immune responses in patients with chronic Trichophyton rubrum infection. Clin. Exp. Dermatol. 2: 373–380.

    CAS  PubMed  Google Scholar 

  • Helander, I. (1978). The lymphocyte transformation test in dermatophytosis. Mykosen 21: 71–80.

    CAS  PubMed  Google Scholar 

  • Hoffmann, J.A., Kafatos, F.C., Janeway, C.A., and Ezekowitz, R.A. (1999). Phylogenetic perspectives in innate immunity. Science 284: 1313–1318.

    Article  CAS  PubMed  Google Scholar 

  • Hunziker, N. and Brun, R. (1980). Lack of delayed reaction in presence of cell-mediated immunity in trichophytin hypersensitivity. Arch. Dermatol. 116: 1266–1268.

    Article  CAS  PubMed  Google Scholar 

  • Johansson, S., Scheynius, A., and Faergemann, J. (1986). Fungal infections inducing HLA-DR but not HLA-DQ transplantation antigens on keratinocytes. Acta Derm. Venereol. (Stockh.) 66: 277–280.

    CAS  Google Scholar 

  • Jones, H.E. (1986). Cell mediated immunity in the immunopathogenesis of dermatophytosis. Acta Derm. Venereol. Suppl. 121: 73–83.

    CAS  Google Scholar 

  • Jones, H.E. (1993). Immune response and host resistance to human dermatophyte infection. J. Am. Acad. Dermatol. 28: S12–S18.

    CAS  PubMed  Google Scholar 

  • Kawai, K., Shimura, H., Minagawa, M., Ito, A., Tomiyama, K., and Ito, M. (2002). Expression of functional toll-like receptor 2 on human epidermal keratinocytes. J. Dermatol. Sci. 30: 185–194.

    Article  CAS  PubMed  Google Scholar 

  • King, R.D., Khan, H.A., Foye, J.C., Greenberg, J.H., and Jones, H.E. (1975). Transferrin, iron, and dermatophytes. I. Serum dermatophyte inhibitory component definitively identified as unsaturated transferrin. J. Clin. Med. 86: 204–212.

    CAS  Google Scholar 

  • Koga, T., Ishizaki, H., Matsumoto, T., and Hori, Y. (1993a). Cytokine production of peripheral blood mononuclear cells in a dermatophytosis patient in response to stimulation with trichophytin. J. Dermatol. 20: 441–443.

    CAS  PubMed  Google Scholar 

  • Koga, T., Ishizaki, H., Matsumoto, T., and Hori, Y. (1993b). In vitro release of interferon-γ by peripheral blood mononuclear cells of patients with dermatophytosis in response to stimulation with trichophytin. Br. J. Dermatol. 128: 703–704.

    CAS  PubMed  Google Scholar 

  • Koga, T., Ishizaki, H., Matsumoto, T., and Hori, Y. (1995). Decreased release of interferon-γ by peripheral blood mononuclear cells of patients with chronic dermatophytosis in response to stimulation with trichophytin. Acta Derm. Venereol. (Stockh.) 75: 81–82.

    CAS  Google Scholar 

  • Koga, T., Ishizaki, H., Matsumoto, T., and Toshitani, S. (1996). Enhanced release of interleukin-8 from human epidermal keratinocytes in response to stimulation with trichophytin in vitro. Acta Derm. Venereol. (Stockh.) 76: 399–400.

    CAS  Google Scholar 

  • Koga, T., Duan, H., Urabe, K., and Furue, M. (2001a). Immunohistochemical detection of interferon-γ-producing cells in dermatophytosis. Eur. J. Dermatol. 11: 105–107.

    CAS  PubMed  Google Scholar 

  • Koga, T., Shimizu, A., and Nakayama, J. (2001b). Interferon-γ production in peripheral lymphocytes of patients with tinea pedis: Comparison of patients with and without Tinea unguium. Med. Mycol. 39: 87–90.

    CAS  PubMed  Google Scholar 

  • Leibovici, V., Evron, R., Axelrod, O., Westerman, M., Shalit, M., Barak, V., and Frankenburg, S. (1995). Imbalance of immune responses in patients with chronic and widespread fungal skin infection. Clin. Exp. Dermatol. 20: 390–394.

    CAS  PubMed  Google Scholar 

  • Medzhitov, R., Preston-Hurlburt, P., and Janeway, C.A. Jr. (1997). A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394–397.

    CAS  PubMed  Google Scholar 

  • Milner, S.M. and Ortega, M.R. (1999). Reduced antimicrobial peptide expression in human burn wounds. Burns 25: 411–413.

    Article  CAS  PubMed  Google Scholar 

  • Miyata, T., Fujimura, T., Masuzawa, M., Katsuoka, K., and Nishiyama, S. (1996). Local expression of IFN-γ mRNA in skin lesion of patients with dermatophytosis. J. Dermatol. Sci. 13: 167–171.

    Article  CAS  PubMed  Google Scholar 

  • Ohta, Y., Saitoh, N., Tanuma, H., Fujimura, T., and Katsuoka, K. (1998). Local cytokine expression in steroid-modified tinea faciei. J. Dermatol. 25: 362–366.

    CAS  PubMed  Google Scholar 

  • Ong, P.Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R.L., and Leung, D.Y. (2002). Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Engl. J. Med. 347: 1151–1160.

    Article  CAS  PubMed  Google Scholar 

  • Picker, L.J., Kishimoto, T.K., Smith, C.W., Warnock, R.A., and Butcher, E.C. (1991). ELAM-1 is an adhesion molecule for skinhoming T cells. Nature 349: 796–799.

    Article  CAS  PubMed  Google Scholar 

  • Pier, A.C., Hodges, A.B, Lauze, J.M., and Raisbeck, M. (1995). Experimental immunity to Microsporum canis and cross reactions with other dermatophytes of veterinary importance. J. Med. Vet. Mycol. 33: 93–97.

    CAS  PubMed  Google Scholar 

  • Porcelli, S.A., Segelke, B.W., Sugita, M., Wilson, I.A., and Brenner, M.B. (1998). The CD1 family of lipid antigen-presenting molecules. Immunol. Today 19: 362–368.

    Article  CAS  PubMed  Google Scholar 

  • Robert, C. and Kupper, T.S. (1999). Inflammatory skin diseases, T cells, and immune surveillance. Allergy/Immunology 341: 1817–1828.

    CAS  Google Scholar 

  • Sato, N. and Tagami, H. (2003). Severe measles in a young female patient with chronic, generalized Trichophyton rubrum infection showing type 2 helper T cell-dominant immunologic reactivity. J. Am. Acad. Dermatol. 48: S43–S46.

    Article  PubMed  Google Scholar 

  • Song, P.I., Park, Y.M., Abraham, T., Harten, B., Zivony, A., Neparidze, N., Armstrong, C.A., and Ansel, J.C. (2002). Human keratinocytes express functional CD14 and toll-like receptor 4. J. Invest. Dermatol. 119: 424–432.

    Article  CAS  PubMed  Google Scholar 

  • Swan, J.W., Dahl, M.A., Coppo, P.A., and Hammerschmidt, D.E. (1983). Complement activation by Trichophyton rubrum. J. Invest. Dermatol. 80: 156–158.

    Article  CAS  PubMed  Google Scholar 

  • Tagami, H., Natsume, N., Aoshima, T., Inoue, F., Suehisa, S., and Yamada, M. (1982). Analysis of transepidermal leucocyte chemotaxis in experimental dermatophytosis in guinea pigs. Arch. Dermatol. Res. 273: 205–217.

    Article  CAS  PubMed  Google Scholar 

  • Takiuchi, I., Higuchi, D., Sei, Y., and Koga, M. (1982). Isolation of an extracellular proteinase (keratinase) from Microsporum canis. Sabouraudia 20: 281–288.

    CAS  PubMed  Google Scholar 

  • Wagner, D.K. and Sohnle, P.G. (1995). Cutaneous defenses against dermatophytes and yeasts. Clin. Microbiol. Rev. 8: 317–335.

    CAS  PubMed  Google Scholar 

  • Weitzman, I. and Summerbell, R.C. (1995). The dermatophytes. Clin. Microbiol. Rev. 8: 240–259.

    CAS  PubMed  Google Scholar 

  • Yu, R.J., Grappel, S.F., and Blank, F. (1972). Inhibition of keratinases by α2-macroglobulin. Experientia 28: 886.

    CAS  PubMed  Google Scholar 

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Koga, T. (2005). Immune Surveillance against Dermatophyte Infection. In: Fidel, P.L., Huffnagle, G.B. (eds) Fungal Immunology. Springer, Boston, MA. https://doi.org/10.1007/0-387-25445-5_22

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