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Immunology of Pulmonary Pneumocystis Infection: Cell-Mediated Immunity

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Fungal Immunology

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10. Summary

Pneumocystis infections remain a serious cause of morbidity and mortality in immunosuppressed hosts, both in HIV-infected individuals and in other immunosuppressed patients. This chapter reviews cell-mediated immune mechanisms that serve to protect the normal host from infection with Pneumocystis or, when defective, lead to the acquisition of pulmonary infection. Alveolar macrophages, CD4+ T cells, CD8+ T cells, and γδ T cells have important roles in defense against Pneumocystis, although their relative contributions require further investigation. Additionally, cytokines and chemokines play vital roles in defense against this organism. Investigations using human cells, as well as animal models and in vitro approaches, have advanced this field recently but many unanswered questions persist. Further investigations examining the roles of these cells and mediators will continue to provide new insights into defense against this important opportunistic pathogen.

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Authors and Affiliations

  1. Division of Pulmonary and Critical Care Medicine, Louisiana State Health Sciences Center, New Orleans, LA

    Judd E. Shellito & James M. Beck

  2. Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, USA

    Judd E. Shellito & James M. Beck

  3. Department of Veterans Affairs Medical Center, Ann Arbor, MI

    Judd E. Shellito & James M. Beck

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  1. Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana

    Paul L. Fidel Jr.

  2. Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan

    Gary B. Huffnagle

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Shellito, J.E., Beck, J.M. (2005). Immunology of Pulmonary Pneumocystis Infection: Cell-Mediated Immunity. In: Fidel, P.L., Huffnagle, G.B. (eds) Fungal Immunology. Springer, Boston, MA. https://doi.org/10.1007/0-387-25445-5_13

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