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14. References

  • Ahmed T, Frey S, Frey JU (2004) Regulation of the phosphodiesterase PDE4B3-isotype during long-term potentiation in the area dentata in vivo. Neuroscience 124:857–867.

    PubMed  CAS  Google Scholar 

  • Ahn S, Ginty DD, Linden DJ (1999) A late phase of cerebellar long-term depression requires activation of CaMKIV and CREB. Neuron 23:559–568.

    PubMed  CAS  Google Scholar 

  • Alarcon JM, Malleret G, Touzani K, Vronskaya S, Ishii S, Kandel ER, Barco A (2004) Chromatin, acetylation, memory, and LTP are impaired in CBP+/− mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron 42:947–959.

    PubMed  CAS  Google Scholar 

  • Athos J, Impey S, Pineda VV, Chen X, Storm DR (2002) Hippocampal CRE-mediated gene expression is required for contextual memory formation. Nat. Neurosci. 5:1119–1120.

    PubMed  CAS  Google Scholar 

  • Bacskai BJ, Hochner B, Mahaut-Smith M, Adams SR, Kaang BK, Kandel ER, Tsien RY (1993) Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science 260:222–226.

    PubMed  CAS  Google Scholar 

  • Bailey CH, Chen M (1989) Time course of structural changes at identified sensory neuron synapses during long-term sensitization in Aplysia. J. Neurosci. 9:1774–1780.

    PubMed  CAS  Google Scholar 

  • Bailey CH, Montarolo P, Chen M, Kandel ER, Schacher S, (1992) Inhibitors of protein and RNA synthesis block structural changes that accompany long-term heterosynaptic plasticity in Aplysia. Neuron 9:749–758.

    PubMed  CAS  Google Scholar 

  • Balschun D, Wolfer DP, Gass P, Mantamadiotis T, Welzl H, Schutz G, Frey JU, Lipp HP (2003) Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory? J. Neurosci. 23:6304–6314.

    PubMed  CAS  Google Scholar 

  • Barco A, Alarcon JM, Kandel ER (2002) Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 108:689–703.

    PubMed  CAS  Google Scholar 

  • Barrientos RM, O’Reilly RC, Rudy JW (2002) Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration. Behav. Brain Res. 134:299–306.

    PubMed  Google Scholar 

  • Barrionuevo G, Schottler F, Lynch G (1980) The effects of repetitive low frequency stimulation on control and “potentiated” synaptic responses in the hippocampus. Life Sci. 27:2385–2391.

    PubMed  CAS  Google Scholar 

  • Barrot M, Olivier JD, Perrotti LI, DiLeone RJ, Berton O, Eisch AJ, Impey S, Storm DR, Neve RL, Yin JC, Zachariou V, Nestler EJ (2002) CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc. Natl. Acad. Sci. USA 99:11435–11440.

    PubMed  CAS  Google Scholar 

  • Bartsch D, Ghirardi M, Skehel PA, Karl KA, Herder SP, Chen M, Bailey CH, Kandel ER (1995) Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change. Cell 83:979–992.

    PubMed  CAS  Google Scholar 

  • Bear MF, Malenka RC (1994) Synaptic plasticity: LTP and LTD. Curr. Opin. Neurobiol. 4:389–399.

    PubMed  CAS  Google Scholar 

  • Bevilaqua LR, Cammarota M, Paratcha G, de Stein ML, Izquierdo I, Medina JH (1999) Experience-dependent increase in cAMP-responsive element binding protein in synaptic and nonsynaptic mitochondria of the rat hippocampus. Eur. J. Neurosci. 11:3753–3756.

    PubMed  CAS  Google Scholar 

  • Bito H, Deisseroth K, Tsien RW (1996) CREB phosphorylation and dephosphorylation: a Ca(2+)-and stimulus duration-dependent switch for hippocampal gene expression. Cell 87:1203–1214.

    PubMed  CAS  Google Scholar 

  • Blendy JA, Kaestner KH, Schmid W, Gass P, Schutz G (1996) Targeting of the CREB gene leads to upregulation of a novel CREB mRNA isoform. Embo. J. 15:1098–1106.

    PubMed  CAS  Google Scholar 

  • Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31–39.

    PubMed  CAS  Google Scholar 

  • Bourtchuladze R, Frenguelli B, Blendy J, Cioffi D, Schutz G, Silva AJ (1994) Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79:59–68.

    PubMed  CAS  Google Scholar 

  • Bozon B, Kelly A, Josselyn SA, Silva AJ, Davis S, Laroche S (2003) MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 358:805–814.

    PubMed  CAS  Google Scholar 

  • Brodie CR, Khaliq M, Yin JC, Brent Clark H, Orr HT, Boland LM (2004) Overexpression of CREB reduces CRE-mediated transcription: behavioral and cellular analyses in transgenic mice. Mol. Cell. Neurosci. 25:602–611.

    PubMed  CAS  Google Scholar 

  • Bunsey M, Eichenbaum H (1995) Selective damage to the hippocampal region blocks long-term retention of a natural and nonspatial stimulus-stimulus association. Hippocampus 5:546–556.

    PubMed  CAS  Google Scholar 

  • Busch SJ, Sassone-Corsi P (1990) Dimers, leucine zippers and DNA-binding domains. Trends Genet. 6:36–40.

    PubMed  CAS  Google Scholar 

  • Byers D, Davis RL, Kiger JA Jr (1981) Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster. Nature 289:79–81.

    PubMed  CAS  Google Scholar 

  • Cammarota M, Bevilaqua LR, Ardenghi P, Paratcha G, Levi de Stein M, Izquierdo I, Medina JH (2000) Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade. Brain Res. Mol. Brain Res. 76:36–46.

    PubMed  CAS  Google Scholar 

  • Carew TJ, Castellucci VF, Kandel ER (1971) An analysis of dishabituation and sensitization of the gillwithdrawal reflex in Aplysia. Int. J. Neurosci. 2:79–98.

    PubMed  CAS  Google Scholar 

  • Carew TJ, Kandel ER (1973) Acquisition and retention of long-term habituation in Aplysia: correlation of behavioral and cellular processes. Science 182:1158–1160.

    PubMed  CAS  Google Scholar 

  • Carlezon WA Jr, Thome J, Olson VG, Lane-Ladd SB, Brodkin ES, Hiroi N, Duman RS, Neve RL, Nestler EJ (1998) Regulation of cocaine reward by CREB. Science 282:2272–2275.

    PubMed  CAS  Google Scholar 

  • Chapman PF (2001) The diversity of synaptic plasticity. Nat. Neurosci. 4:556–558.

    PubMed  CAS  Google Scholar 

  • Chen RH, Sarnecki C, Blenis J (1992) Nuclear localization and regulation of erk-and rsk-encoded protein kinases. Mol. Cell. Biol. 12:915–927.

    PubMed  CAS  Google Scholar 

  • Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365:855–859.

    PubMed  CAS  Google Scholar 

  • Cleary LJ, Lee WL, Byrne JH (1998) Cellular correlates of long-term sensitization in Aplysia. J. Neurosci. 18:5988–5998.

    PubMed  CAS  Google Scholar 

  • Cole TJ, Copeland NG, Gilbert DJ, Jenkins NA, Schutz G, Ruppert S (1992) The mouse CREB (cAMP responsive element binding protein) gene: structure, promoter analysis, and chromosomal localization. Genomics 13:974–982.

    PubMed  CAS  Google Scholar 

  • Countryman RA, Orlowski JD, Brightwell JJ, Oskowitz AZ, Colombo PJ (2004) CREB phsophorylation and c-Fox expression in the hippocampus of rats during acquisition and recall of a socially transmitted food preference. Hippocampus, In press.

    Google Scholar 

  • Danielian PS, White R, Hoare SA, Fawell SE, Parker MG (1993) Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen. Mol. Endocrinol. 7:232–240.

    PubMed  CAS  Google Scholar 

  • Dash PK, Hochner B, Kandel ER (1990) Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Nature 345:718–721.

    PubMed  CAS  Google Scholar 

  • Dash PK, Karl KA, Colicos MA, Prywes R, Kandel ER (1991) cAMP response element-binding protein is activated by Ca2+/calmodulin-as well as cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 88:5061–5065.

    PubMed  CAS  Google Scholar 

  • Davis HP, Squire LR (1984) Protein synthesis and memory: a review. Psychol. Bull. 96:518–559.

    PubMed  CAS  Google Scholar 

  • Davis M (1992) The role of the amygdala in fear and anxiety. Annu. Rev. Neurosci. 15:353–375.

    PubMed  CAS  Google Scholar 

  • Davis S, Vanhoutte P, Pages C, Caboche J, Laroche S (2000) The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. J. Neurosci. 20:4563–4572.

    PubMed  CAS  Google Scholar 

  • Deisseroth K, Bito H, Tsien RW (1996) Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron 16:89–101.

    PubMed  CAS  Google Scholar 

  • Desmedt A, Hazvi S, Dudai Y (2003) Differential pattern of cAMP response element-binding protein activation in the rat brain after conditioned aversion as a function of the associative process engaged: taste versus context association. J. Neurosci. 23:6102–6110.

    PubMed  CAS  Google Scholar 

  • Dubnau J, Chiang AS, Grady L, Barditch J, Gossweiler S, McNeil J, Smith P, Buldoc F, Scott R, Certa U, Broger C, Tully T (2003) The staufen/pumilio pathway is involved in Drosophila long-term memory. Curr. Biol. 13:286–296.

    PubMed  CAS  Google Scholar 

  • Dudai Y, Jan YN, Byers D, Quinn WG, Benzer S (1976) dunce, a mutant of Drosophila deficient in learning. Proc. Natl. Acad. Sci. USA 73:1684–1688.

    PubMed  CAS  Google Scholar 

  • Dudek SM, Bear MF (1992) Homosynaptic long-term depression in area CA1 of hippocampus and effects of Nmethyl-D-aspartate receptor blockade. Proc. Natl. Acad. Sci. USA 89:4363–4367.

    PubMed  CAS  Google Scholar 

  • Ebbinghaus H (1885) Uber das Gedachtnis. New York: Dover.

    Google Scholar 

  • Falls WA, Kogan JH, Silva AJ, Willott JF, Carlson S, Turner JG (2000) Fear-potentiated startle, but not prepulse inhibition of startle, is impaired in CREB alphadelta-/-mutant mice. Behav. Neurosci. 114:998–1004.

    PubMed  CAS  Google Scholar 

  • Fanselow MS, Gale, GD (2003) The amygdala, fear, and memory. Ann. N. Y. Acad. Sci. 985:125–134.

    PubMed  Google Scholar 

  • Feil R, Brocard J, Mascrez B, LeMeur M, Metzger D, Chambon P (1996) Ligand-activated site-specific recombination in mice. Proc. Natl. Acad. Sci. USA 93:10887–10890.

    PubMed  CAS  Google Scholar 

  • Fimia GM, De Cesare D, Sassone-Corsi P (1998) Mechanisms of activation by CREB and CREM: phosphorylation, CBP, and a novel coactivator, ACT. Cold Spring Harb. Symp. Quant. Biol. 63:631–642.

    PubMed  CAS  Google Scholar 

  • Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME (1997) CREB: a major mediator of neuronal neurotrophin responses. Neuron 19:1031–1047.

    PubMed  CAS  Google Scholar 

  • Foulkes NS, Borrelli E, Sassone-Corsi P (1991) CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64:739–749.

    PubMed  CAS  Google Scholar 

  • Foulkes NS, Sassone-Corsi P (1992) More is better: activators and repressors from the same gene. Cell 68:411–414.

    PubMed  CAS  Google Scholar 

  • Frankland PW, Cestari V, Filipkowski RK, McDonald RJ, Silva AJ (1998) The dorsal hippocampus is essential for context discrimination but not for contextual conditioning. Behav. Neurosci. 112:863–874.

    PubMed  CAS  Google Scholar 

  • Frankland PW, Josselyn SA (2004) CREB and long-term memory. In: Memories are made of these: from messengers to molecules (Ed. by Riedel, G. & Platt, B.). Georgetown, Tx: Landes Bioscience.

    Google Scholar 

  • Frankland PW, Josselyn SA, Anagnostaras SG, Kogan JH, Takahashi E, Silva AJ (2004) Consolidation of CS and US representations in associative fear conditioning. Hippocampus 14:557–559.

    PubMed  Google Scholar 

  • Frey U, Huang YY, Kandel ER (1993) Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science 260:1661–1664.

    PubMed  CAS  Google Scholar 

  • Frey U, Krug M, Reymann KG, Matthies H (1988) Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro. Brain Res. 452:57–65.

    PubMed  CAS  Google Scholar 

  • Frost WN, Clark GA, Kandel ER (1988) Parallel processing of short-term memory for sensitization in Aplysia. J. Neurobiol. 19:297–334.

    PubMed  CAS  Google Scholar 

  • Frost WN, Kandel ER (1995) Structure of the network mediating siphon-elicited siphon withdrawal in Aplysia. J. Neurophysiol. 73:2413–2427.

    PubMed  CAS  Google Scholar 

  • Galef BG Jr, Mason JR, Preti G, Bean NJ (1988) Carbon disulfide: a semiochemical mediating socially-induced diet choice in rats. Physiol. Behav. 42:119–124.

    PubMed  CAS  Google Scholar 

  • Galef BG Jr, Wigmore SW, Kennett DJ (1983) A failure to find socially mediated taste aversion learning in Norway rats (R. norvegicus). J. Comp. Psychol. 97:358–363.

    PubMed  Google Scholar 

  • Garcia J, Kimeldorf DJ, Koelling RA (1995) Conditioned aversion to saccharin resulting from exposure to gamma radiation. Science 122:157–158.

    Google Scholar 

  • Gass P, Wolfer DP, Balschun D, Rudolph D, Frey U, Lipp HP, Schutz G (1998) Deficits in memory tasks of mice with CREB mutations depend on gene dosage. Learn. Mem. 5:274–288.

    PubMed  CAS  Google Scholar 

  • Genoux D, Haditsch U, Knobloch M, Michalon A, Storm D, Mansuy IM (2002) Protein phosphatase 1 is a molecular constraint on learning and memory. Nature 418:970–975.

    PubMed  CAS  Google Scholar 

  • Ghosh MK, Cohen JS (1992) Oligodeoxynucleotides as antisense inhibitors of gene expression. Prog. Nucleic Acid Res. Mol. Biol. 42:79–126.

    PubMed  CAS  Google Scholar 

  • Giebler HA, Lemasson I, Nyborg JK (2000) p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation. Mol. Cell. Biol. 20:4849–4858.

    PubMed  CAS  Google Scholar 

  • Goelet P, Castellucci VF, Schacher S, Kandel ER (1986) The long and the short of long-term memory—a molecular framework. Nature 322:419–422.

    PubMed  CAS  Google Scholar 

  • Gonzalez GA, Montminy MR (1989) Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59:675–680.

    PubMed  CAS  Google Scholar 

  • Goosens KA, Maren S (2002) Long-term potentiation as a substrate for memory: evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning. Hippocampus 12:592–599.

    PubMed  Google Scholar 

  • Graves L, Dalvi A, Lucki I, Blendy JA, Abel T (2002) Behavioral analysis of CREB alphadelta mutation on a B6/129 F1 hybrid background. Hippocampus 12:18–26.

    PubMed  CAS  Google Scholar 

  • Guzowski JF, McGaugh JL (1997) Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training. Proc. Natl. Acad. Sci. USA 94:2693–2698.

    PubMed  CAS  Google Scholar 

  • Hagiwara M, Alberts A, Brindle P, Meinkoth J, Ferarnisco J, Deng T, Karin M, Shenolikar S, Montminy M (1992) Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell 70:105–113.

    PubMed  CAS  Google Scholar 

  • Hagiwara M, Brindle P, Harootunian A, Armstrong R, Rivier J, Vale W, Tsien R, Montminy MR (1993) Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol. Cell. Biol. 13:4852–4859.

    PubMed  CAS  Google Scholar 

  • Hardingham GE, Arnold FJ, Bading H (2001) Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. Nat. Neurosci. 4:261–267.

    PubMed  CAS  Google Scholar 

  • Hoeffler JP (1992) Structure/function relationships of CREB/ATF proteins. J. Invest. Dermatol. 98:21S–28S.

    PubMed  CAS  Google Scholar 

  • Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (1988) Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 242:1430–1433.

    PubMed  CAS  Google Scholar 

  • Huang YY, Martin KC, Kandel ER (2000) Both protein kinase A and mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term potentiation. J. Neurosci. 20:6317–6325.

    PubMed  CAS  Google Scholar 

  • Huang YY, Pittenger C, Kandel ER (2004) A form of long-lasting, learning-related synaptic plasticity in the hippocampus induced by heterosynaptic low-frequency pairing. Proc. Natl. Acad. Sci. USA 101:859–864.

    PubMed  CAS  Google Scholar 

  • Hummler E, Cole TJ, Blendy JA, Ganss R, Aguzzi A, Schmid W, Beermann F, Schutz G (1994) Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc. Natl. Acad. Sci. USA 91:5647–5651.

    PubMed  CAS  Google Scholar 

  • Impey S, Mark M, Villacres EC, Poser S, Chavkin C, Storm DR (1996) Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus. Neuron 16:973–982.

    PubMed  CAS  Google Scholar 

  • Impey S, Smith DM, Obrietan K, Donahue R, Wade C, Storm DR (1998) Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. Nat. Neurosci. 1:595–601.

    PubMed  CAS  Google Scholar 

  • Josselyn SA, Shi C, Carlezon WA Jr, Neve RL, Nestler EJ, Davis M (2001) Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala. J. Neurosci. 21:2404–2412.

    PubMed  CAS  Google Scholar 

  • Kaang BK, Kandel ER, Grant SG (1993) Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons. Neuron 10:427–435.

    PubMed  CAS  Google Scholar 

  • Kandel ER (1981) Calcium and the control of synaptic strength by learning. Nature 293:697–700.

    PubMed  CAS  Google Scholar 

  • Kandel ER (2001) The molecular biology of memory storage: a dialogue between genes and synapses. Science 294:1030–1038.

    PubMed  CAS  Google Scholar 

  • Kaplan MP, Abel T (2003) Genetic approaches to the study of synaptic plasticity and memory storage. CNS Spectr. 8:597–610.

    PubMed  Google Scholar 

  • Kida S, Josselyn SA, de Ortiz SP, Kogan JH, Chevere I, Masushige S, Silva AJ (2002) CREB required for the stability of new and reactivated fear memories. Nat. Neurosci. 5:348–355.

    PubMed  CAS  Google Scholar 

  • Kogan JH, Frankland PW, Blendy JA, Coblentz J, Marowitz Z, Schutz G, Silva AJ (1997) Spaced training induces normal long-term memory in CREB mutant mice. Curr. Biol. 7:1–11.

    PubMed  CAS  Google Scholar 

  • Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg ME (2002) CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron 34:221–233.

    PubMed  CAS  Google Scholar 

  • Lamprecht R, Hazvi S, Dudai Y (1997) cAMP response element-binding protein in the amygdala is required for long-but not short-term conditioned taste aversion memory. J. Neurosci. 17:8443–8450.

    PubMed  CAS  Google Scholar 

  • LeDoux JE (2000) Emotion circuits in the brain. Annu. Rev. Neurosci. 23:155–184.

    PubMed  CAS  Google Scholar 

  • Levin LR, Han PL, Hwang PM, Feinstein PG, Davis RL, Reed RR (1992) The Drosophila learning and memory gene rutabaga encodes a Ca2+/Calmodulin-responsive adenylyl cyclase. Cell 68:479–489.

    PubMed  CAS  Google Scholar 

  • Lin CH, Yeh SH, Lu KT, Leu TH, Chang WC, Gean PW (2001) A role for the P1-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala. Neuron 31:841–851.

    PubMed  CAS  Google Scholar 

  • Linden DJ, Connor JA (1995) Long-term synaptic depression. Annu. Rev. Neurosci. 18:319–357.

    PubMed  CAS  Google Scholar 

  • Livingstone MS, Sziber PP, Quinn WG (1984) Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant. Cell 37:205–215.

    PubMed  CAS  Google Scholar 

  • Logie C, Stewart AF (1995) Ligand-regulated site-specific recombination. Proc. Natl. Acad. Sci. USA 92:5940–5944.

    PubMed  CAS  Google Scholar 

  • Lu YF, Kandel ER, Hawkins RD (1999) Nitric oxide signaling contributes to late-phase LTP and CREB phosphorylation in the hippocampus. J. Neurosci. 19:10250–10261.

    PubMed  CAS  Google Scholar 

  • Lynch G (1998) Memory and the brain: unexpected chemistries and a new pharmacology. Neurobiol. Learn. Mem. 70:82–100.

    PubMed  CAS  Google Scholar 

  • Mantamadiotis T, Lemberger T, Bleckmann SC, Kern H, Kretz O, Martin-Villalba A, Tronche F, Kellendonk C, Gau D, Kapfhammer J, Otto C, Schmid W, Schutz G (2002) Disruption of CREB function in brain leads to neurodegeneration. Nat. Genet. 31:47–54.

    PubMed  CAS  Google Scholar 

  • Maren S, Aharonov G, Fanselow MS (1997) Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behav. Brain Res. 88:261–274.

    PubMed  CAS  Google Scholar 

  • Maren S, Baudry M (1995) Properties and mechanisms of long-term synaptic plasticity in the mammalian brain: relationships to learning and memory. Neurobiol. Learn. Mem. 63:1–18.

    PubMed  CAS  Google Scholar 

  • Martin KC, Casadio A, Zhu H, Yaping E, Rose JC, Chen M, Bailey CH, Kandel ER (1997) Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage. Cell 91:927–938.

    PubMed  CAS  Google Scholar 

  • Martin SJ, Grimwood PD, Morris RG (2000) Synaptic plasticity and memory: an evaluation of the hypothesis. Annu. Rev. Neurosci. 23:649–711.

    PubMed  CAS  Google Scholar 

  • Matthies H (1989) In search of cellular mechanisms of memory. Prog. Neurobiol. 32:277–349.

    PubMed  CAS  Google Scholar 

  • Matthies H, Schulz S, Thiemann W, Siemer H, Schmidt H, Krug M, Hollt V (1997) Design of a multiple slice interface chamber and application for resolving the temporal pattern of CREB phosphorylation in hippocampal long-term potentiation. J. Neurosci. Methods 78:173–179.

    PubMed  CAS  Google Scholar 

  • Matus-Amat P, Higgins EA, Barrientos RM, Rudy JW (2004) The role of the dorsal hippocampus in the acquisition and retrieval of context memory representations. J. Neurosci. 24:2431–2439.

    PubMed  CAS  Google Scholar 

  • Matynia A, Kushner SA, Silva AJ (2002) Genetic approaches to molecular and cellular cognition: a focus on LTP and learning and memory. Annu. Rev. Genet. 36:687–720.

    PubMed  CAS  Google Scholar 

  • Mauelshagen J, Sherff CM, Carew TJ (1998) Differential induction of long-term synaptic facilitation by spaced and massed applications of serotonin at sensory neuron synapses of Aplysia californica. Learn. Mem. 5:246–256.

    PubMed  CAS  Google Scholar 

  • McLean JH, Harley CW, Darby-King A, Yuan Q (1999) pCREB in the neonate rat olfactory bulb is selectively and transiently increased by odor preference-conditioned training. Learn. Mem. 6:608–618.

    PubMed  CAS  Google Scholar 

  • Molina CA, Foulkes NS, Lalli E, Sassone-Corsi P (1993) Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Cell 75:875–886.

    PubMed  CAS  Google Scholar 

  • Morris RG, Garrud P, Rawlins JN, O’Keefe J (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297:681–683.

    PubMed  CAS  Google Scholar 

  • Moser El, Krobert KA, Moser MB, Morris RG (1998) Impaired spatial learning after saturation of long-term potentiation. Science 281:2038–2042.

    PubMed  CAS  Google Scholar 

  • Mower AF, Liao DS, Nestler EJ, Neve RL, Ramoa AS (2002) cAMP/Ca2+ response element-binding protein function is essential for ocular dominance plasticity. J. Neurosci. 22:2237–2245.

    PubMed  CAS  Google Scholar 

  • Nguyen PV, Abel T, Kandel ER (1994) Requirement of a critical period of transcription for induction of a late phase of LTP. Science 265:1104–1107.

    PubMed  CAS  Google Scholar 

  • Ogawa S, Pfaff DW (1996) Application of antisense DNA method for the study of molecular bases of brain function and behavior. Behav. Genet. 26:279–292.

    PubMed  CAS  Google Scholar 

  • Pandey SC, Mittal N, Silva AJ (2000) Blockade of cyclic AMP-responsive element DNA binding in the brain of CREB delta/alpha mutant mice. Neuroreport 11:2577–2580.

    PubMed  CAS  Google Scholar 

  • Pinsker H, Kupfermann I, Castellucci V, Kandel E (1970) Habituation and dishabituation of the gill-withdrawal reflex in Aplysia. Science 167:1740–1742.

    PubMed  CAS  Google Scholar 

  • Pinsker HM, Hening WA, Carew TJ, Kandel ER (1973) Long-term sensitization of a defensive withdrawal reflex in Aplysia. Science 182:1039–1042.

    PubMed  CAS  Google Scholar 

  • Pittenger C, Huang YY, Paletzki RF, Bourtchouladze R, Scanlin H, Vronskaya S, Kandel ER (2002) Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory. Neuron 34:447–462.

    PubMed  CAS  Google Scholar 

  • Quinn WG, Harris WA, Benzer S (1974) Conditioned behavior in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 71:708–712.

    PubMed  CAS  Google Scholar 

  • Quinn WG, Sziber PP, Booker R (1979) The Drosophila memory mutant amnesiac. Nature 277:212–214.

    PubMed  CAS  Google Scholar 

  • Rammes G, Steckler T, Kresse A, Schutz G, Zieglgansberger W, Lutz B (2000) Synaptic plasticity in the basolateral amygdala in transgenic mice expressing dominant-negative cAMP response element-binding protein (CREB) in forebrain. Eur. J. Neurosci. 12:2534–2546.

    PubMed  CAS  Google Scholar 

  • Rehfuss RP, Walton KM, Loriaux MM, Goodman RH (1991) The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. J. Biol. Chem. 266:18431–18434.

    PubMed  CAS  Google Scholar 

  • Ribeiro MJ, Serfozo Z, Papp A, Kemenes I, O’Shea M, Yin JC, Benjamin PR, Kemenes G (2003) Cyclic AMP response element-binding (CREB)-like proteins in a molluscan brain: cellular localization and learning-induced phosphorylation. Eur. J. Neurosci. 18:1223–1234.

    PubMed  Google Scholar 

  • Rosenblum K, Meiri N, Dudai Y (1993) Taste memory: the role of protein synthesis in gustatory cortex. Behav. Neural Biol. 59:49–56.

    PubMed  CAS  Google Scholar 

  • Rudolph D, Tafuri A, Gass P, Hammerling GJ, Arnold B, Schutz G (1998) Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein. Proc. Natl. Acad. Sci. USA 95:4481–4486.

    PubMed  CAS  Google Scholar 

  • Sadamoto H, Sato H, Kobayashi S, Murakami J, Aonuma H, Ando H, Fujito Y, Hamano K, Awaji M, Lukowiak K, Urano A, Ito E (2004) CREB in the pond snail Lymnaea stagnalis: cloning, gene expression, and function in identifiable neurons of the central nervous system. J. Neurobiol. 58:455–466.

    PubMed  CAS  Google Scholar 

  • Schafe GE, LeDoux JE (2000) Memory consolidation of auditory pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala. J. Neurosci. 20:RC96.

    PubMed  CAS  Google Scholar 

  • Scharf MT, Woo NH, Lattal KM, Young JZ, Nguyen PV, Abel T (2002) Protein synthesis is required for the enhancement of long-term potentiation and long-term memory by spaced training. J. Neurophysiol. 87:2770–2777.

    PubMed  CAS  Google Scholar 

  • Schulz S, Siemer H, Krug M, Hollt V (1999) Direct evidence for biphasic cAMP responsive element-binding protein phosphorylation during long-term potentiation in the rat dentate gyrus in vivo. J. Neurosci. 19:5683–5692.

    PubMed  CAS  Google Scholar 

  • Shors TJ, Matzel LD (1997) Long-term potentiation: what’s learning got to do with it? Behav. Brain Sci. 20:597–614.

    PubMed  CAS  Google Scholar 

  • Silva AJ (2003) Molecular and cellular cognitive studies of the role of synaptic plasticity in memory. J. Neurobiol. 54:224–237.

    PubMed  CAS  Google Scholar 

  • Simonato M, Manservigi R, Marconi P, Glorioso J (2000) Gene transfer into neurones for the molecular analysis of behaviour: focus on herpes simplex vectors. Trends Neurosci. 23:183–190.

    PubMed  CAS  Google Scholar 

  • Stanciu M, Radulovic J, Spiess J (2001) Phosphorylated cAMP response element binding protein in the mouse brain after fear conditioning: relationship to Fos production. Brain Res. Mol. Brain Res. 94:15–24.

    PubMed  CAS  Google Scholar 

  • Stanton PK, Sarvey JM (1984) Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis. J. Neurosci. 4:3080–3088.

    PubMed  CAS  Google Scholar 

  • Staubli U, Lynch G (1990) Stable depression of potentiated synaptic responses in the hippocampus with 1–5 Hz stimulation. Brain Res. 513:113–118.

    PubMed  CAS  Google Scholar 

  • Stork O, Welzl H (1999) Memory formation and the regulation of gene expression. Cell. Mol. Life Sci. 55:575–592.

    PubMed  CAS  Google Scholar 

  • Sun P, Enslen H, Myung PS, Maurer RA (1994) Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity. Genes Dev. 8:2527–2539.

    PubMed  CAS  Google Scholar 

  • Sutherland RJ, Kolb B, Whishaw IQ (1982) Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the rat. Neurosci. Lett. 31:271–276.

    PubMed  CAS  Google Scholar 

  • Swank MW (2000) Phosphorylation of MAP kinase and CREB in mouse cortex and amygdala during taste aversion learning. Neuroreport 11:1625–1630.

    PubMed  CAS  Google Scholar 

  • Taubenfeld SM, Milekic MH, Monti B, Alberini CM (2001a) The consolidation of new but not reactivated memory requires hippocampal C/EBPbeta. Nat. Neurosci. 4:813–818.

    PubMed  CAS  Google Scholar 

  • Taubenfeld SM, Wiig KA, Bear MF, Alberini CM (1999) A molecular correlate of memory and amnesia in the hippocampus. Nat. Neurosci. 2:309–310.

    PubMed  CAS  Google Scholar 

  • Taubenfeld SM, Wiig KA, Monti B, Dolan B, Pollonini G, Alberini CM (2001b) Fornix-dependent induction of hippocampal CCAAT enhancer-binding protein [beta] and [delta] Co-localizes with phosphorylated cAMP response element-binding protein and accompanies long-term memory consolidation. J. Neurosci. 21:84–91.

    PubMed  CAS  Google Scholar 

  • Tully T (1991) Physiology of mutations affecting learning and memory in Drosophila—the missing link between gene product and behavior. Trends Neurosci. 14:163–164.

    PubMed  CAS  Google Scholar 

  • Tully T, Preat T, Boynton SC, Del Vecchio M (1994) Genetic dissection of consolidated memory in Drosophila. Cell 79:35–47.

    PubMed  CAS  Google Scholar 

  • Viola H, Furman M, Izquierdo LA, Alonso M, Barros DM, de Souza MM, Izquierdo I, Medina JH (2000) Phosphorylated cAMP response element-binding protein as a molecular marker of memory processing in rat hippocampus: effect of novelty. J. Neurosci. 20:RC112.

    PubMed  CAS  Google Scholar 

  • Wadzinski BE, Wheat WH, Jaspers S, Peruski LF Jr, Lickteig RL, Johnson GL, Klemm DJ (1993) Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Mol. Cell. Biol. 13:2822–2834.

    PubMed  CAS  Google Scholar 

  • Waeber G, Meyer TE, LeSieur M, Hermann HL, Gerard N, Habener JF (1991) Developmental stage-specific expression of cyclic adenosine 3′,5′-monophosphate response element-binding protein CREB during spermatogenesis involves alternative exon splicing. Mol. Endocrinol. 5:1418–1430.

    PubMed  CAS  Google Scholar 

  • Wahlestedt C (1994) Antisense oligonucleotide strategies in neuropharmacology. Trends Pharmacol. Sci. 15:42–46.

    PubMed  CAS  Google Scholar 

  • Wallace TL, Stellitano KE, Neve RL, Duman RS (2004) Effects of cyclic adenosine monophosphate response element binding protein overexpression in the basolateral amygdala on behavioral models of depression and anxiety. Biol. Psychiatry 56:151–160.

    PubMed  CAS  Google Scholar 

  • Walters CL, Blendy JA (2001) Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse. J. Neurosci. 21:9438–9444.

    PubMed  CAS  Google Scholar 

  • Walton KM, Rehfuss RP, Chrivia JC, Lochner JE, Goodman RH (1992) A dominant repressor of cyclic adenosine 3′,5′-monophosphate (cAMP)-regulated enhancer-binding protein activity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo. Mol. Endocrinol. 6:647–655.

    PubMed  CAS  Google Scholar 

  • Wang H, Ferguson GD, Pineda VV, Cundiff PE, Storm DR (2004) Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP. Nat. Neurosci. 7:635–642.

    PubMed  CAS  Google Scholar 

  • Wiltgen BJ, Sanders MJ, Behne NS, Fanselow MS (2001) Sex differences, context preexposure, and the immediate shock deficit in Pavlovian context conditioning with mice. Behav. Neurosci. 115:26–32.

    PubMed  CAS  Google Scholar 

  • Woo NH, Duffy SN, Abel T, Nguyen PV (2003) Temporal spacing of synaptic stimulation critically modulates the dependence of LTP on cyclic AMP-dependent protein kinase. Hippocampus 13:293–300.

    PubMed  CAS  Google Scholar 

  • Wu GY, Deisseroth K, Tsien RW (2001) Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activiated protein kinase pathway. Proc. Natl. Acad. Sci. USA 98:2808–2813.

    PubMed  CAS  Google Scholar 

  • Xie S, Price JE, Luca M, Jean D, Ronai Z, Bar-Eli M (1997) Dominant-negative CREB inhibits tumor growth and metastasis of human melanoma cells. Oncogene 15:2069–2075.

    PubMed  CAS  Google Scholar 

  • Xing J, Ginty DD, Greenberg ME (1996) Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273:959–963.

    PubMed  CAS  Google Scholar 

  • Yamamoto KK, Gonzalez GA, Menzel P, Rivier J, Montminy MR (1990) Characterization of a bipartite activator domain in transcription factor CREB. Cell 60:611–617.

    PubMed  CAS  Google Scholar 

  • Yamamoto T, Fujimoto Y (1991) Brain mechanisms of taste aversion learning in the rat. Brain Res. Bull. 27:403–406.

    PubMed  CAS  Google Scholar 

  • Yang SN, Huang LT, Wang CL, Chen WF, Yang CH, Lin SZ, Lai MC, Chen SJ, Tao PL (2003) Prenatal administration of morphine decreases CREBSerine-133 phosphorylation and synaptic plasticity range mediated by glutamatergic transmission in the hippocampal CA1 area of cognitive-deficient rat offspring. Hippocampus 13:915–921.

    PubMed  CAS  Google Scholar 

  • Yin JC, Del Vecchio M, Zhou H, Tully T (1995) CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 81:107–115.

    PubMed  CAS  Google Scholar 

  • Yin JC, Tully T (1996) CREB and the formation of long-term memory. Curr. Opin. Neurobiol. 6:264–268.

    PubMed  CAS  Google Scholar 

  • Yin JC, Wallach JS, Del Vecchio M, Wilder EL, Zhou H, Quinn WG, Tully T (1994) Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 79:49–58.

    PubMed  CAS  Google Scholar 

  • Yuan Q, Harley CW, Darby-King A, Neve RL, McLean JH (2003) Early odor preference learning in the rat: bidirectional effects of cAMP response element-binding protein (CREB) and mutant CREB support a causal role for phosphorylated CREB. J. Neurosci. 23:4760–4765.

    PubMed  CAS  Google Scholar 

  • Zhang JJ, Okutani F, Inoue S, Kaba H (2003) Activation of the cyclic AMP response element-binding protein signaling pathway in the olfactory bulb is required for the acquisition of olfactory aversive learning in young rats. Neuroscience 117:707–713.

    PubMed  CAS  Google Scholar 

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Josselyn, S.A., Mortezavi, M., Silva, A.J. (2005). CREB: A Cornerstone of Memory Consolidation?. In: Stanton, P.K., Bramham, C., Scharfman, H.E. (eds) Synaptic Plasticity and Transsynaptic Signaling. Springer, Boston, MA. https://doi.org/10.1007/0-387-25443-9_21

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