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Small-Animal Spect Imaging pp 177–182Cite as

Estimates of Axial and Transaxial Resolution for One-, Two-, and Three-Camera Helical Pinhole SPECT

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Abstract

There is ongoing work to improve the sensitivity and resolution of pinhole collimation for small-animal studies [Moore, 1991, Strand,1994,Weber, 1994, Jaszczak, 1994, Ishizu, 1995, Tsui, 2001, Beekman, 2001, Metzler, 2001, Beekman, 2002a, Beekman, 2002b, Metzler, 2002, Ogowa, 1998, Kastis, 2002, Acton, 2002]. One method is the reduction of radius of rotation [Mortimer, 1954].

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References

  1. P.D. Acton, S.R. Choi, K. Plössl, H.F. Kung, “Quantification of Dopamine Transporters in the Mouse Brain Using Ultra-high Resolution Single-photon Emission Tomography,” Eur. J. Nucl. Med., vol. 29(5), pp. 691–698, 2002.

    Article  Google Scholar 

  2. F.J. Beekman, D.P. McElroy, F. Berger, E.J. Hoffman, and S.R. Cherry, “Sub-millimeter resolution I-125 in vivo imaging in mice using micro-pinholes,” J. Nucl. Med., vol. 42(5)(Suppl.), pp. 204, 2001.

    Google Scholar 

  3. F.J. Beekman, D.P. McElroy, F. Berger, S.S. Gambhir, E.J. Hoffman, and S.R. Cherry, “Towards in vivo Nuclear Microscopy: I-125 Imaging in Mice using Micro-pinholes,” Eur J. Nucl. Med., vol. 29(7), pp. 933–938, 2002.

    Article  Google Scholar 

  4. M. Gieles, H.W.A.M de Jong and F.J. Beekman, “Accelerated Monte Carlo simulation of micro-pinhole imaging using Kernel Forced Detection,” Phys. Med. Biol., vol. 47(11), pp. 1853–1867, 2002.

    Article  Google Scholar 

  5. R.J. Jaszczak, J. Li, H. Wang, M.R. Zalutsky, and R.E. Coleman, “Pinhole collimation for ultra-high-resolution, small-field-of-view SPECT,” Phys. Med. Biol., vol. 39, pp. 425–437, 1994.

    Article  Google Scholar 

  6. H.M. Hudson and R.S. Larkin, “Accelerated Image Reconstruction Using Ordered Subsets of Projection Data,” IEEE Trans. Med. Imag., vol. 13(4), pp. 601–609, 1994.

    Article  Google Scholar 

  7. K. Ishizu, T. Mukai, Y. Yonekura, M. Pagani, T. Fujita, Y. Magata, S. Nishizawa, N. Tamaki, H. Shibasaki, and J. Konishi, “Ultra-high Resolution SPECT System Using Four Pinhole Collimators for Small Animal Studies,” J. Nucl. Med., vol. 36(12), pp. 2282–2287, 1995.

    Google Scholar 

  8. G.A. Kastis et al., “Tomographic Small-animal Imaging Using a High-resolution Semiconductor Camera,” IEEE Trans. Nucl. Sci., vol. 49, pp. 172–175, 2002.

    Article  Google Scholar 

  9. S.D. Metzler, J.E. Bowsher, M.F. Smith, and R.J. Jaszczak, “Analytic Determination of Pinhole Sensitivity with Penetration,” IEEE Trans. Med. Img., vol. 20(8), pp. 730–741, 2001.

    Article  Google Scholar 

  10. S.D. Metzler, J.E. Bowsher, K.L. Greer, and R.J. Jaszczak, “Analytic Determination of the Pinhole Collimator’s Point-Spread Function and RMS Resolution with Penetration,” IEEE Trans. Med. Img., 2002.

    Google Scholar 

  11. S.D. Metzler, K.L. Greer, and R.J. Jaszczak, “Helical Pinhole SPECT for Small-Animal Imaging: A Method for Addressing Sampling Completeness,” IEEE Trans. Nucl. Sci., vol. 50(5), pp. 1575–1583, 2003.

    Article  Google Scholar 

  12. R.H. Moore, H. Ohtani, B.A. Khaw, and H.W. Strauss, “High Resolution Pinhole Sequence Imaging of Small Laboratory Animals,” Cancer, vol. 32(5), p. 987, 1991.

    Google Scholar 

  13. R.K. Mortimer, H.O. Anger, and C.A. Tobias, “The Gamma Ray Pinhole Camera with Image Amplifier,” Convention Record of the Institute or Radio Engineers, Part 9 — Medical and Nuclear Electronics, pp. 2–5, 1954.

    Google Scholar 

  14. K. Ogawa, T. Kawade, K. Nakamura, A. Kubo, T. Ichihara, “Ultra High Resolution Pinhole SPECT for Small Animal Study,” IEEE Trans. Nucl. Sci., vol. 45, pp. 3122–3126, 1998.

    Article  Google Scholar 

  15. B.D. Smith, “Image Reconstruction from Cone-Beam Projections: Necessary and Sufficient Conditions and Reconstruction Methods,” IEEE Trans. Med. Imag., vol. MI-4(1), pp. 14–25, 1985.

    Article  Google Scholar 

  16. S-E. Strand, M. Ivanovic, K. Erlandsson, D. Franceschi, T. Burton, K. Sjogren, and D.A. Weber, “Small Animal Imaging with Pinhole Single-Photon Emission Computed Tomography,” Cancer, vol. 73(3), pp. 981–984, 1994.

    Article  Google Scholar 

  17. B.M.W. Tsui, Y. Wang, E.C. Frey, and D.E. Wessell, “Application of Ultra High-Resolution Pinhole SPECT System Based on a Conventional Camera for Small Animal Imaging,” J. Nucl. Med., vol. 42(5), pp. 54P–55P, 2001.

    Google Scholar 

  18. H.K. Tuy, “An Inversion Formula for Cone-Beam Reconstruction,” SIAM J. Appl. Math., vol. 43(3), pp. 546–552, 1983.

    Article  MathSciNet  Google Scholar 

  19. D.A. Weber, M. Ivanovic, D. Franceschi, S-E. Strand, K. Erlandsson, M. Franceschi, H.L. Atkins, J.A. Coderre, H. Susskind, T. Button, and K. Ljunggren, “Pinhole SPECT: An Approach to in vivo High Resolution SPECT Imaging in Small Laboratory Animals,” J. Nucl. Med., vol. 35(2), pp. 342–348, 1994.

    Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Duke University Medical Center, Durham, North Carolina

    Scott D. Metzler

  2. Department of Biomedical Engineering, Duke University, Durham, North Carolina

    Ronald J. Jaszczak

Authors
  1. Scott D. Metzler
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  2. Ronald J. Jaszczak
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Editor information

Editors and Affiliations

  1. Optical Science Center, The University of Arizona, Tucson, AZ, 85721, USA

    Matthew A. Kupinski  & Harrison H. Barrett  & 

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Metzler, S.D., Jaszczak, R.J. (2005). Estimates of Axial and Transaxial Resolution for One-, Two-, and Three-Camera Helical Pinhole SPECT. In: Kupinski, M.A., Barrett, H.H. (eds) Small-Animal Spect Imaging. Springer, Boston, MA. https://doi.org/10.1007/0-387-25294-0_9

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  • DOI: https://doi.org/10.1007/0-387-25294-0_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-25143-1

  • Online ISBN: 978-0-387-25294-0

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