Abstract
Amyloidosis refers to a diverse group of diseases characterized by the abnormal extracellular deposition of proteinaceous substances within the body’s organs and tissues. The protein substances are known as amyloid and consist of insoluble fibrils. In general, amyloid deposits arise due to the overproduction of an amyloidogenic protein or as a result of a genetic mutation that occurs in a normally soluble, innocuous, protein that renders it amyloidogenic.Amyloid deposits have been found in virtually every organ and tissue and may be of a restricted localized form or systemic and involve multiple organ or tissue systems.More than 20 proteins have been identified as components of pathologic amyloid deposits, including the A(β) peptide in Alzheimer’s disease; amylin in Type-2 diabetes;and the prion protein in the spongiform encephalopathies such as mad cow disease. Our focus is on AA-and AL-amyloidosis, which respectively are composed of apolipoprotein A synthesized during chronic inflammation and immunoglobulin light chains synthesized by abnormal plasma cells.
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Gregor, J. et al. (2005). A Micro-SPECT/CT System for Imaging of AA-Amyloidosis in Mice. In: Kupinski, M.A., Barrett, H.H. (eds) Small-Animal Spect Imaging. Springer, Boston, MA. https://doi.org/10.1007/0-387-25294-0_14
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DOI: https://doi.org/10.1007/0-387-25294-0_14
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