Cottontails and gopherweed: Anti-feeding compounds from a spurge

  • Dietland Müller-Schwarze
  • José Giner
Conference paper


Mammalian herbivores nearly never attack gopherweed, Euphorbia lathyris (Euphorbiaceae). To find the chemical principle responsible for the deterrent effect, we field-tested plant extracts in response-guided bioassays for antifeedant activity. We treated winter-dormant apple twigs with extract solutions and presented them to free-ranging eastern cottontails, Sylvilagus floridanus, at 3 different home ranges in Upstate New York during late winter. Extracts from all plant parts reduced feeding, measured as twig tips cut and amount of bark removed, but root extracts were most active. The bioassay led to isolation of putative antifeedant compounds from the root extract, a series of long-chain alkyl ferulates and gopherenediol, a new diterpenoid. Bioassay of docosanyl ferulate and gopherenediol demonstrated weak antifeedant activity. The bioassays are continuing.


Home Range Root Extract Mammalian Herbivore Leafy Spurge Ferulate Medium 
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  1. Calvin, M., Nemethy, E.K., Redenbaugh, K., and Otvos, J. W., 1982, Plants as a direct source of fuel, Experientia 38:18–22.CrossRefGoogle Scholar
  2. Duke, J. A., 1983/2003, Euphorbia lathyris L., Euphorbiaceae. Mole plant, petroleum plant, caper spurge, gopher plant. Handbook of Energy Crops. Scholar
  3. Giner, J.-L., Zhao, H., Schroeder, T., and Müller-Schwarze, D., submitted, Gopherenediol: A novel diterpenoid isolated as a putative rodent antifeedant from the roots of Euphorbia lathyris.Google Scholar
  4. Halaweish, F., Kronberg, S., Hubert, M. B., and Rice, J. A., 2002, Toxic and aversive diterpenes of Euphorbia esula, J. Chem. Ecol. 28:1599–1611.PubMedCrossRefGoogle Scholar
  5. Halaweish, F., Kronberg, S., and Rice, J. A., 2003, Rodent and ruminant ingestive response to flavanoids in Euphorbia esula, J. Chem. Ecol. 29:1073–1082.PubMedCrossRefGoogle Scholar
  6. Hein, D. G., and Miller, S. D., 1992, Influence of leafy spurge on forage utilization by cattle, J. Range Manage. 45:405–407.Google Scholar
  7. Hohmann, J., Evanics, F., Vasas, A., Dombi, G., Jerkovich, G., and Máthé, I., 1999, A novel lathyrane diterpenoid from the roots of Euphorbia lathyris, J. Nat. Prod. 62:176–178.PubMedCrossRefGoogle Scholar
  8. Kronberg, S. L., Lynch, W. C., Cheney, C. D., and Walker, J. W., 1995, Potential aversive compounds in leafy spurge for ruminants and rats, J. Range Manage. 21:1387–1399.Google Scholar
  9. Kronberg, S. L., Muntifering, R. B., Ayers, E. L., and Marlow, C. B., 1993, Cattle avoidance of leafy spurge: A case of conditioned aversion, J. Range Manage. 46:364–366.Google Scholar
  10. Sachs, R. M., Low, C. B., Macdonald, J. D., Awad, A. R., and Sully, M. J., 1981, Euphorbia lathyris: a potential source of petroleum-like products, Cal. Agr. 35:29–32.Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Dietland Müller-Schwarze
    • 2
  • José Giner
    • 1
  1. 1.Department of Chemistry, College of Environmental Science and ForestryState University of New YorkSyracuse
  2. 2.Department of Environmental and Forest Biology, College of Environmental Science and ForestryState University of New YorkSyracuse

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