6. Concluding Remarks
Calcium release from the SR in skeletal muscle is brought about by opening of RyR/calcium release channels. RyR can be activated by Ca2+ (CICR), but physiological opening of RyR is not mediated by Ca2+. RyR is considered to open physiologically as a result of interaction with voltage sensor protein in the T-tubule membrane, and its opening mode is quite different from that of CICR. The physiological mode of opening is mimicked by clofibric acid and possibly by cerivastatin in the absence of Ca2+. On the other hand, CICR mode of opening of RyR in skeletal muscle plays the major role in MH or during caffeine action. The exact operation of RyRs in physiological calcium release remains to be solved.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Costantin, L., L., 1970, The role of sodium current in the radial spread of contraction in frog muscle fibers. J. Gen. Physiol. 55:703–715.
Denborough, M. A. and Lovell, R. R. H., 1960, Anesthetic deaths in a family. Lancet II: 45.
Ebashi, S. and Endo, M., 1968, Calcium ion and muscle contraction, in: Progr. in Biophys. and Mol. Biol. Vol. 18: J. A. V. Butler, and D. Noble, eds., Pergamon Press, Oxford, pp. 123–183.
Endo, M., 1964, Entry of a dye into the sarcotubular system of muscle. Nature 202:1115–1116.
Endo, M., Entry of fluorescent dyes into the sarcotubular system of the frog muscle. J. Physiol. 185:224–238.
Endo, M., 1981, Mechanism of calcium-induced calcium release in the SR membrane, in: The Mechanism of Gated Calcium Transport across Biological Membranes S. T. Ohnishi, and M. Endo, eds., Academic Press, N.Y., pp.257–264.
Endo, M., 1984, Significance of calcium-induced release of calcium from the sarcoplasmic reticulum in skeletal muscle. Jikeikai Med. J. 30:Suppl. 1, 123–130.
Endo, M. and Iino, M., 1988, Measurement of Ca2 + release in skinned fibers from skeletal muscle. Methods in Enzymology 157:12–26.
Endo, M., Tanaka, M. and Ogawa, Y., 1970, Calcium-induced release of calcium from the sarcoplasmic reticulum of skinned skeletal muscle fibres. Nature 228:34–36.
Endo, M., Yagi, S., Ishizuka, T., Horiuti, K., Koga, Y. and Amaha, K., 1983, Changes in the Cainduced Ca release mechanism in the sarcoplasmic reticulum of the muscle from a patient with malignant hyperthermia. Biomed. Res. 4: 83–92.
Fabiato, A. and Fabiato, F., 1972, Excitation-contraction coupling of isolated cardiac fibers with disrupted or closed sarcolemmas. Calcium-dependent cyclic and tonic contractions. Circulation Res. 31:293–307.
Fleischer, S. E., Ogunbunmi, E. M., Dixon, M. C. and Fleer, E. A., 1985, Localization of Ca2+ channels with ryanodine in junctional terminal cisternae of sarcoplasmic reticulum of fast skeletal muscle. Proc Natl. Acad. Sci. USA 82:7256–7259.
Ford, L. E. and Podolsky, R. D., 1970, Regenerative calcium release within muscle cells. Science 167:58–59.
Garcia, J., and Schneider, M., F., 1995, Suppression of calcium release by calcium or procaine in voltage clamped rat skeletal muscle fibres. J Physiol. 485:437–445.
Hill, A., V., 1949, The abrupt transition from rest to activity in muscle. Proc. Roy. Soc. (London), Ser. B, 136:399–420.
Huxley, A. F. and Taylor, R. E., 1955, Function of Krause’s membrane. Nature, 176:1068.
Huxley, A. F. and Taylor, R. E., 1958, Local activation of striated muscle fibres. J. Physiol., 144:426–441.
Huxley, H. E., 1964, Evidence for continuity between the central elements of the triads and extracellular space in frog sartorius muscle Nature 202:1067–1071.
Ikemoto, T. and Endo, M., 2001, Properties of Ca2+ release induced by clofibric acid from sarcoplasmic reticulum of mouse skeletal muscle fibres. Brit. J. Pharmacol. 134: 719–728.
Ikemoto, T., Hosoya, T., Aoyama, T., Kihara, Y., Suzuki, M. and Endo, M., 2001, Effects of dantrolene and its derivatives on Ca2+ release from the sarcoplasmic reticulum of mouse skeletal muscle fibres. Brit. J. Pharmacol. 134, 729–736.
Imagawa, T., Smith, J. S., Coronado, R. and Campbell, K. P., 1987, Purified ryanodine receptor from skeletal muscle sarcoplasmic reticulum is the Ca2+ permeable pore of the calcium release channel. J. Biol. Chem. 262:16636–16643.
Inoue, R., Tanabe, M., Kono, K., Maruyama, K., Ikemoto, T. and Endo, M., 2003, Ca2+-releasing effect of cerivastatin on the sarcoplasmic reticulum of mouse and rat skeletal muscle fibers. J. Pharmacol Sci. 93:279–288.
Inui, M., Saito, A. and Fleischer, S., 1987, Purification of the ryanodine receptor and identity with feet structures of junctional terminal cisternae of sarcoplasmic reticulum from fast skeletal muscle. J. Biol. Chem. 262:1740–1747.
Ishizuka, T. and Endo, M., 1983, Effects of adenine on skinned fibers of amphibian fast skeletal muscle. Proc. Japan Acad. 59: 93–96.
Ishizuka, T., Iijima, T. and Endo, M., 1983, Effect of adenine on twitch and other contractile responses of single fibers of amphibian fast skeletal muscle. Proc. Japan Acad. 59: 97–100.
Kalow, W., Britt, B. A., Terreau, M. E. and Haist C., 1970, Metabolic error of muscle metabolism after recovery from malignant hyperthermia. Lancet II: 895–898.
Kawana, Y., Iino, M., Horiuti, K., Matsumura, N., Ohta, T., Matsui, K. and Endo, M., 1992, Accerelation in calcium-induced calcium release in the biopsied muscle fibers from patients with malignant hyperthermia. Biomed. Res. 13: 287–297.
Kobayashi, T. and Endo, M., 1988, Temperature-dependent inhibition of caffeine contracture of mammalian skeletal muscle by dantrolene. Proc. Japan Acad. 64:76–79.
Lai, F. A., Erickson, H. P., Rousseau, E., Liu, Q.-Y. and Meissner, G., 1988, Nature 331:315–319.
Matsui, K. and Endo, M., 1986, Effect of inhalation anesthetics on the rate of Ca release from the sarcoplasmic reticulum of skeletal muscle in the guinea-pig. Jap. J. Pharmacol. 40:Supple. 245P.
Natori, R., 1954, The property and contraction process of isolated myofbrils. Jikeikai Med. J. 1:119–126.
Ohta, T. and Endo, M., 1986, Inhibition of calcium-induced calcium release by dantrolene at mammalian body temperature. Proc. Japan Acad. 62:329–332.
Porter, K. R. and Palade, G. E., 1957, Studies on the endoplasmic reticulum. III. Its form and distribution in striated muscle cells. J. Biophys. Biochem. Cytol., 3:269–300.
Sorrentino, V. and Volpe, P., 1993, Ryanodine receptors: how many, where and why? Trends. Pharmacol Sci. 14:98–103.
Takeshima, H., Iino, M., Takekura, H., Nishi, M., Kuno, J., Minowa, O., Takano, H. and Noda, T., 1994, Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine receptor gene. Nature 369:556–559.
Thorens, S. and Endo, M., 1975, Calcium-induced calcium release and “depolarization”-induced calcium release: their physiological significance. Proc. Japan Acad. 51: 473–478.
Weber, A. and Herz, R., 1968, The relationship between caffeine contracture of intact muscle and the effect of caffeine on reticulum. J. Gen. Physiol. 52:750–759.
Yamazawa, T., Takeshima, H., Sakurai, T., Endo, M. and Iino, M., 1996, Subtype specificity of the ryanodine receptor for Ca2+ signal amplification in excitation-contraction coupling. EMBO J. 15, 6172–6177.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer Science+Business Media, Inc.
About this paper
Cite this paper
Endo, M. (2005). Mechanisms of Calcium Release from the Sarcoplasmic Reticulum in Skeletal Muscle. In: Sugi, H. (eds) Sliding Filament Mechanism in Muscle Contraction. Advances in Experimental Medicine and Biology, vol 565. Springer, Boston, MA. https://doi.org/10.1007/0-387-24990-7_18
Download citation
DOI: https://doi.org/10.1007/0-387-24990-7_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-24989-6
Online ISBN: 978-0-387-24990-2
eBook Packages: MedicineMedicine (R0)