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Hematopoietic Stem Cell Transplantation for the Treatment of Severe Autoimmune Diseases

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Molecular Autoimmunity

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12. Conclusions

The role of stem cell transplantation in the treatment of severe, therapyrefractory AD remains experimental, with data on around 700 patients being sufficiently encouraging to proceed to randomized prospective trials in the major diseases: SSc, RA, MS, and soon JIA and SLE. An impressive international collaboration has and is reducing duplication of efforts with shared databases, protocols, patient selection, and end points. The concept of resetting a dysbalance in the complex immune network, rather than total eradication of clonal autoimmunity, is emerging. Further clinical trials are required to establish the place, if any, HSCT has in such treatment, and a basic science program continues to explain the pathophysiological mechanisms of these immune-modulating strategies.

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  1. Department of Rheumatology, University Hospital, Basle, Switzerland

    Alan Tyndall

  2. Department of Rheumatology, Kantonsspital, Aarau, Switzerland

    Paul Hasler

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  1. Institut National de Santé et de Recherche Médicale (INSERM), Paris, France

    Moncef Zouali

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Tyndall, A., Hasler, P. (2005). Hematopoietic Stem Cell Transplantation for the Treatment of Severe Autoimmune Diseases. In: Zouali, M. (eds) Molecular Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/0-387-24534-0_24

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