Skip to main content

Extent of Regulatory T Cell Influence on Major Histocompatibility Complex Class II Gene Control of Susceptibility in Murine Autoimmune Thyroiditis

  • Chapter
Molecular Autoimmunity

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Beisel, K.W., David, C.S., Giraldo, A.A., Kong, Y.M., and Rose, N.R. (1982). Regulation of experimental autoimmune thyroiditis: Mapping of susceptibility to the I-A subregion of the mouse H-2. Immunogenetics, 15, 427–431.

    Article  CAS  PubMed  Google Scholar 

  • Cannons, J.L., Lau, P., Ghumman, B., Debenedette, M.A., Yagita, H., Okumura, K., and Watts, T.H. (2001). 4-1bb ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy. J. Immunol., 167, 1313–1324.

    CAS  PubMed  Google Scholar 

  • Caspi, R.R. (1998). IL-12 in autoimmunity. Clin. Immunol. Immunopathol., 88, 4–13.

    Article  CAS  PubMed  Google Scholar 

  • Dinarello, C.A. (1989). Interleukin-1 and its biologically related cytokines. Adv. Immunol., 44, 153–205.

    CAS  PubMed  Google Scholar 

  • Elrehewy, M., Kong, Y.M., Giraldo, A.A., and Rose, N.R. (1981). Syngeneic thyroglobulin is immunogenic in good responder mice. Eur. J. Immunol., 11, 146–151.

    CAS  PubMed  Google Scholar 

  • Fuller, B.E., Okayasu, I., Simon, L.L., Giraldo, A.A., and Kong, Y.M. (1993). Characterization of resistance to murine experimental autoimmune thyroiditis: Duration and afferent action of thyroglobulin-and TSH-induced suppression. Clin. Immunol. Immunopathol., 69, 60–68.

    Article  CAS  PubMed  Google Scholar 

  • Germann, T., Szeliga, J., Hess, H., Störkel, S., Podlaski, F.J., Gately, M.K., Schmitt, E., and Rüde, E. (1995). Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice. Proc. Natl. Acad. Sci. USA, 92, 4823–4827.

    CAS  PubMed  Google Scholar 

  • Kong, Y.M. (1999). In R. Volpe (ed.), Contemporary Endocrinology: Autoimmune Endocrinopathies. Humana Press, Totowa, New Jersey. pp. 91–111.

    Google Scholar 

  • Kong, Y.M. and David, C.S. (2000). New revelations in susceptibility to autoimmune thyroiditis by the use of H2 and HLA class II transgenic models. Int. Rev. Immunol., 19, 573–585.

    CAS  PubMed  Google Scholar 

  • Kong, Y.M., David, C.S., Lomo, L.C., Fuller, B.E., Motte, R.W., and Giraldo, A.A. (1997). Role of mouse and human class II transgenes in susceptibility to and protection against mouse autoimmune thyroiditis. Immunogenetics, 46, 312–317.

    Article  CAS  PubMed  Google Scholar 

  • Kong, Y.M., Flynn, J.C., Wan, Q., and David, C.S. (2003). HLA and H2 class II transgenic mouse models to study susceptibility and protection in autoimmune thyroid disease. Autoimmunity, 36, 397–404.

    Article  CAS  PubMed  Google Scholar 

  • Kong, Y.M., Giraldo, A.A., Waldmann, H., Cobbold, S.P., and Fuller, B.E. (1989). Resistance to experimental autoimmune thyroiditis: L3T4+ cells as mediators of both thyroglobulin-activated and TSH-induced suppression. Clin. Immunol. Immunopathol., 51, 38–54.

    Article  CAS  PubMed  Google Scholar 

  • Kong, Y.M., Lomo, L.C., Motte, R.W., Graldo, A.A., Baisch, J., Strauss, G., Hämmerling, G.J., and David, C.S. (1996). HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: Definitive association with HLA-DRB1*0301 (DR3) gene. J. Exp. Med., 184, 1167–1172.

    Article  CAS  PubMed  Google Scholar 

  • Kong, Y.M., Okayasu, I., Giraldo, A.A., Beisel, K.W., Sundick, R.S., Rose, N.R., David, C.S., Audibert, F., and Chedid, L. (1982). Tolerance to thyroglobulin by activating suppressor mechanisms. Ann. NY Acad. Sci., 392, 191–209.

    CAS  PubMed  Google Scholar 

  • Leonard, J.P., Waldburger, K.E., Schaub, R.G., Smith, T., Hewson, A.K., Cuzner, M.L., and Goldman, S.J. (1997). Regulation of the inflammatory response in animal models of multiple sclerosis by interleukin-12. Crit. Rev. Immunol., 17, 545–553.

    CAS  PubMed  Google Scholar 

  • Lewis, M., Fuller, B.E., Giraldo, A.A., and Kong, Y.M. (1992). Resistance to experimental autoimmune thyroiditis is correlated with the duration of raised thyroglobulin levels. Clin. Immunol. Immunopathol., 64, 197–204.

    Article  CAS  PubMed  Google Scholar 

  • Lewis, M., Giraldo, A.A., and Kong, Y.M. (1987). Resistance to experimental autoimmune thyroiditis induced by physiologic manipulation of thyroglobulin level. Clin. Immunol. Immunopathol., 45, 92–104.

    Article  CAS  PubMed  Google Scholar 

  • McHugh, R.S. and Shevach, E.M. (2002). Cutting edge: Depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J. Immunol., 168, 5979–5983.

    CAS  PubMed  Google Scholar 

  • Melero, I., Johnston, J.V., Shufford, W.W., Mittler, R.S., and Chen, L. (1998). NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell. Immunol., 190, 167–172.

    Article  CAS  PubMed  Google Scholar 

  • Mignon-Godefroy, K., Brazillet, M.P., Rott, O., and Charreire, J. (1995). Distinctive modulation by IL-4 And IL-10 of the effector function of murine thyroglobulin-primed cells in “transferexperimental autoimmune thyroiditis.” Cell. Immunol., 162, 171–177.

    Article  CAS  PubMed  Google Scholar 

  • Morris, G.P., Chen, L., and Kong, Y.M. (2003). CD137 signaling interferes with activation and function of CD4+CD25+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis. Cell. Immunol., 226, 20–29.

    Article  CAS  PubMed  Google Scholar 

  • Morris, G.P. and Kong, Y.M. (2004). Naturally-existing CD4+CD25+ regulatory T cells: A peripheral barrier to autoimmune thyroiditis. Turkish J. Endocrinol. Metab. 8(Suppl. 1):28.

    Google Scholar 

  • Morris, G.P., Yan, Y., David, C.S., and Kong, Y.M. (2004). CD4+CD25+ regulatory T cells modulate autoimmune thyroiditis, but do not supersede MHC class II restriction in the novel H2aE+ transgenic model. Clin. Invest. Med., 27, 93b.

    Google Scholar 

  • Nabozny, G.H. and Kong, Y.M. (1992). Circumvention of the induction of resistance in murine experimental autoimmune thyroiditis by recombinant IL-1β. J. Immunol., 149, 1086–1092.

    CAS  PubMed  Google Scholar 

  • Pennline, K.J., Roque-Gaffney, E., and Monahan, M. (1994). Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin. Immunol. Immunopathol., 71, 169–175.

    Article  CAS  PubMed  Google Scholar 

  • Racke, M.K., Bonomo, A., Scott, D.E., Cannella, B., Levine, A., Raine, C.S., Shevach, E.M., and Rocken, M. (1994). Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med., 180, 1961–1966.

    Article  CAS  PubMed  Google Scholar 

  • Rapoport, M.J., Jaramillo, A., Zipris, D., Lazarus, A.H., Serreze, D.V., Leiter, E.H., Cyopick, P., Danska, J.S., and Delovitch, T.L. (1993). Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med., 178, 87–99.

    Article  CAS  PubMed  Google Scholar 

  • Rott, O., Fleischer, B., and Cash, E. (1994). Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur. J. Immunol., 24, 1434–1440.

    CAS  PubMed  Google Scholar 

  • Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., and Toda, M. (1995). Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor A-chains (CD25): Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol., 155, 1151–1164.

    CAS  PubMed  Google Scholar 

  • Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., and Sakaguchi, S. (2002). Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol., 3, 135–142.

    Article  CAS  PubMed  Google Scholar 

  • Staruch, M.J. and Wood, D.D. (1983). The adjuvanticity of interleukin 1 in vivo. J. Immunol., 130, 2191–2194.

    CAS  PubMed  Google Scholar 

  • Sun, Y., Lin, X., Chen, H.M., Wu, Q., Subudhi, S.K., Chen, L., and Fu, Y.-X. (2002). Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J. Immunol., 168, 1457–1465.

    CAS  PubMed  Google Scholar 

  • Thornton, A.M. and Shevach, E.M. (2000). Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J. Immunol., 164, 183–190.

    CAS  PubMed  Google Scholar 

  • Tone, M., Tone, Y., Adams, E., Yates, S.F., Frewin, M.R., Cobbold, S.P., and Waldmann, H. (2003). Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc. Natl. Acad. Sci. USA, 100, 15059–15064.

    Article  CAS  PubMed  Google Scholar 

  • Trembleau, S., Penna, G., Bosi, E., Mortara, A., Gately, M.K., and Adorini, L. (1995). Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med., 181, 817–821.

    Article  CAS  PubMed  Google Scholar 

  • Vladutiu, A.O. and Rose, N.R. (1971). Autoimmune murine thyroiditis: Relation to histocompatibility (H-2) type. Science, 174, 1137–1139.

    CAS  PubMed  Google Scholar 

  • Wan, Q., Shah, R., Mccormick, D.J., Lomo, L.C., Giraldo, A.A., David, C.S., and Kong, Y.M. (1999). H2-E transgenic class II-negative mice can distinguish self from nonself in susceptibility to heterologous thyroglobulins in autoimmune thyroiditis. Immunogenetics, 50, 22–30.

    Article  CAS  PubMed  Google Scholar 

  • Wan, Q., Shah, R., Panos, J.C., Giraldo, A.A., David, C.S., and Kong, Y.M. (2002). HLA-DR and HLA-DQ polymorphism in human thyroglobulin-induced autoimmune thyroiditis: DR3 and DQ8 transgenic mice are susceptible. Hum. Immunol., 63, 301–310.

    Article  CAS  PubMed  Google Scholar 

  • Wei, W.-Z., Morris, G.P., and Kong, Y.M. (2004). Anti-tumor immunity and autoimmunity: A balancing act of regulatory T cells. Cancer Immunol. Immunother., 53, 73–78.

    Article  CAS  PubMed  Google Scholar 

  • Zhang, W., Flynn, J.C., and Kong, Y.M. (2001). IL-12 prevents tolerance induction with mouse thyroglobulin by priming pathogenic T cells in experimental autoimmune thyroiditis: Role of IFN-γ and the costimulatory molecules CD40L and CD28. Cell. Immunol., 208, 52–61.

    Article  CAS  PubMed  Google Scholar 

  • Zhang, W. and Kong, Y.M. (1998). Noninvolvement of IL-4 and IL-10 in tolerance induction to experimental autoimmune thyroiditis. Cell. Immunol., 187, 95–102.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Science+Business Media, Inc.

About this chapter

Cite this chapter

Kong, Yc.M., Morris, G.P., David, C.S. (2005). Extent of Regulatory T Cell Influence on Major Histocompatibility Complex Class II Gene Control of Susceptibility in Murine Autoimmune Thyroiditis. In: Zouali, M. (eds) Molecular Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/0-387-24534-0_15

Download citation

Publish with us

Policies and ethics