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Molecular Recognition in the Immune System

  • Chapter
Proteomics and Protein-Protein Interactions

Part of the book series: Protein Reviews ((PRON,volume 3))

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Abstract

Antibody and T-cell receptor (TCR) molecules may be regarded as products of a protein engineering system for the generation of a virtually unlimited repertoire of complementary molecular surfaces. This extreme structural heterogeneity is required for recognition of the infinite array of antigenic determinants presented in nature. Here we broadly discuss the structures of antibodies and TCRs as well as their specific recognition of antigen, the binding energetics of these interactions, the structural basis of the antibody maturation and TCR selection processes, limitations to affinity and specificity for antigens, and the role of conformational flexibility in antigen recognition. A final section highlights research results from the burgeoning field of natural killer cell receptor biology.

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  1. Center for Advanced Research in Biotechnology, W.M. Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD, 20850, USA

    Eric J. Sundberg & Roy A. Mariuzza

  2. Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA, 02472, USA

    Eric J. Sundberg

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  1. Institute of Structural Molecular Biology, Birkbeck and University College London, UK

    Gabriel Waksman

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Sundberg, E.J., Mariuzza, R.A. (2005). Molecular Recognition in the Immune System. In: Waksman, G. (eds) Proteomics and Protein-Protein Interactions. Protein Reviews, vol 3. Springer, Boston, MA. https://doi.org/10.1007/0-387-24532-4_4

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