Leptomeningeal Metastasis of Primary Central Nervous System (CNS) Neoplasms

  • Herbert H. Engelhard
  • Luke A. Corsten
Part of the Cancer Treatment and Research book series (CTAR, volume 125)


Leptomeningeal dissemination of primary CNS tumors varies widely by histologic subtype. In certain tumors including medulloblastoma, ependymoma, germ cell tumors, and primary CNS lymphoma, seeding of the cerebrospinal fluid space is a critical factor in determining stage, prognosis and appropriate therapy. Other tumor types, such as glioma, may have radiographic evidence of leptomeningeal metastases without clear impact on prognosis or therapy.

Key Words

Medulloblastoma ependymoma glioma primary CNS lymphoma leptomeningeal metastases 


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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Herbert H. Engelhard
    • 1
  • Luke A. Corsten
    • 1
  1. 1.The University of Illinois at ChicagoChicagoIllinois

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