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Leptomeningeal Metastases from Leukemias and Lymphomas

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Leptomeningeal Metastases

Part of the book series: Cancer Treatment and Research ((CTAR,volume 125))

Abstract

Leptomeningeal dissemination of lymphoma and leukemia differs from that of solid tumors in a number of clinically important aspects. Specific histologic variants of lymphoma and leukemia have such a high incidence of cerebrospinal fluid (CSF) dissemination that assessing CSF cytology at diagnosis is crucial and prophylactic therapy of the CSF compartment is required. Furthermore, while the overall prognosis for patients with leptomeningeal metastases from leukemia and lymphoma is similar to solid tumors, selected patients have excellent response to therapy and attain durable remission. Therefore, aggressive treatment is warranted.

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Author information

Authors and Affiliations

  1. Department of Neurology, Memorial Sloan-Kettering Cancer Center, 12745 York Avenue, New York, NY, 10021

    Craig P. Nolan M.D. & Lauren E. Abrey M.D.

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  1. Craig P. Nolan M.D.
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  2. Lauren E. Abrey M.D.
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Editor information

Editors and Affiliations

  1. Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021

    Lauren E. Abrey M.D.

  2. Department of Neurology, University of Southern California, Norris Comprehensive Cancer Center and Hospital, Los Angeles, CA, 90033

    Marc C. Chamberlain M.D.

  3. Departments of Neurosurgery, Bioengineering & Molecular Genetics, University of Illinois at Chicago, Chicago, IL, 60612

    Herbert H. Engelhard M.D., PhD.

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Nolan, C.P., Abrey, L.E. (2005). Leptomeningeal Metastases from Leukemias and Lymphomas. In: Abrey, L.E., Chamberlain, M.C., Engelhard, H.H. (eds) Leptomeningeal Metastases. Cancer Treatment and Research, vol 125. Springer, Boston, MA. https://doi.org/10.1007/0-387-24199-X_4

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  • DOI: https://doi.org/10.1007/0-387-24199-X_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-24198-2

  • Online ISBN: 978-0-387-24199-9

  • eBook Packages: MedicineMedicine (R0)

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