Anatomy and Physiology of the Leptomeninges and CSF Space

  • Neil Barshes
  • Alexis Demopoulos
  • Herbert H. Engelhard
Part of the Cancer Treatment and Research book series (CTAR, volume 125)


The arachnoid membrane and pia mater are the two membranous layers that comprise the leptomeninges. Cerebrospinal fluid is made within the ventricular system by cells of the choroid plexus and ependyma. This chapter describes in detail the normal anatomic structure and physiologic interactions of the cerebrospinal fluid and leptomeningeal space that are critical to our understanding and treatment of leptomeningeal metastases.

Key words

Arachnoid pia mater leptomeninges cerebrospinal fluid 


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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Neil Barshes
    • 1
  • Alexis Demopoulos
    • 2
  • Herbert H. Engelhard
    • 1
  1. 1.The University of Illinois at ChicagoChicago
  2. 2.Memorial Sloan-Kettering Cancer CenterNew York

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