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Specific and Non-Specific Natural Killer Cell Responses to Viral Infection

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Mechanisms of Lymphocyte Activation and Immune Regulation X

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 560))

Abstract

Initially identified by their ability to kill tumor cells without prior sensitization of the host, natural killer (NK) cells are now known to provide a crucial initial defense against pathological organisms. In particular, they play a critical role during the early phases of infection (days 0 to 5) while specific immunity develops (reviewed in [1]). Recent advances, however, indicate that NK cells specifically recognize virus-infected cells in a manner akin to their recognition of tumor cells, and also respond non-specifically to viral infections.

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Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Washington University School of Medicine and Barnes-Jewish Hospital, Box 8045, St. Louis, Missouri, 63110

    Wayne M. Yokoyama

Authors
  1. Wayne M. Yokoyama
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Editor information

Editors and Affiliations

  1. University of California Irvine, Irvine, California

    Sudhir Gupta

  2. NIAID, NIH, Bethesda, Maryland

    William E. Paul

  3. Rockefeller University, New York, New York

    Ralph Steinman

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© 2005 Springer Science + Business Media, Inc.

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Yokoyama, W.M. (2005). Specific and Non-Specific Natural Killer Cell Responses to Viral Infection. In: Gupta, S., Paul, W.E., Steinman, R. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation X. Advances in Experimental Medicine and Biology, vol 560. Springer, Boston, MA. https://doi.org/10.1007/0-387-24180-9_8

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