Abstract
Thymic stromal lymphopoietin (TSLP) is a novel interleukin (1L)-7-like cytokine [1]. The functional receptor for TSLP is a heterodimer consisting of the IL-7Rα chain and a common γ chain-like receptor called TSLP receptor (TSLPR) [1], [2]. In humans, IL-7Rα chain and TSLPR mRNA are coexpressed on CDl lc+ immature myeloid dendritic cells (DCs), but not in other cell types [2]. Because human TSLP activates peripheral blood CDl lc+ immature DCs, we investigated how TSLP-activated DCs (TSLP-DCs) regulate human naive CD4+ T cell activation and differentiation [3],[4].
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Watanabe, N., Soumelis, V., Liu, YJ. (2005). Human Thymic Stromal Lymphopoietin Triggers Dendritic Cell-Mediated Allergic Inflammation and CD4+ T Cell Homeostatic Expansion. In: Gupta, S., Paul, W.E., Steinman, R. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation X. Advances in Experimental Medicine and Biology, vol 560. Springer, Boston, MA. https://doi.org/10.1007/0-387-24180-9_10
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DOI: https://doi.org/10.1007/0-387-24180-9_10
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