Summary
An association between sex steroids and mammographic density (MD), a predictor of breast cancer (BC) risk, is supported by findings of increased densities after hormone therapy and reduced densities after tamoxifen treatment. Herein, ethnic differences in urinary hormone levels and their relation to MDs were investigated. Because 2-hydroxyestrone (2-OH-E1) is considered less carcinogenic than 16α-hydroxyestrone(16α-OH-E1), we hypothesized an inverse relation between the 2-OH-E1/16α-OH-E1 (2/16) ratio and breast densities. Women recruited completed a questionnaire and donated urine during the luteal phase. Urinary estrone (E1), estradiol (E2), testosterone (T), and 5α-androstane-3α, 17β-diol (ADIOL) were measured by indirect radioimmunoassay (RIA) and 16α- and 2-OH-E1 by competitive immunoassays. MDs were assessed with a computer-assisted method and applied multiple linear regressions. The total number of subjects was 305 (35–75 years, \( \bar X \) = 47.2 years). Their ethnic distribution was Caucasian (110), Japanese (86), Hawaiian (35), Chinese (28), and mixed/other ethnicity (46). The data indicate that the body mass index (BMI), 2-OH-E1, androgens (A), total hormones, and the 2/16 ratio were significantly lower in Asians than in Caucasians, but the % MDs were 22% higher in Asians. None of the individual hormones was associated with MDs. However, contrary to the initial hypothesis, the 2/16 ratio was directly related to MDs. The ratio was 25% lower in the lowest MD category as compared to the highest category. The data suggest that the effects of endogenous hormones on BC risk may not be mediated through MDs in adult women.
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References
Boyd NF, Lockwood GA, Byng JW, et al (1998) Mammographic densities and breast cancer risk. Cancer Epidemiol Biomarkers Prev 7:1133–1144.
Toniolo PG, Levitz M, Zeleniuch-Jacquotte A, et al (1995) A prospective study of endogenous estrogens and breast cancer in postmenopausal women. J Natl Cancer Inst 87:190–197.
Hankinson SE, Willett WC, Manson JE, et al (1998) Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women. J Natl Cancer Inst 90:1292–1299.
Cauley JA, Lucas FL, Kuller LH, et al (1999) Elevated serum estradiol and testosterone concentrations are associated with a high risk for breast cancer. Study of Osteoporotic Fractures Res Group. Ann Intern Med 130:270–277.
Greendale GA, Reboussin BA, Slone S, et al (2003) Postmenopausal hormone therapy and change in mammographic density. J Natl Cancer Inst 95:30–37.
Brisson J, Brisson B, Cote G, et al (2000) Tamoxifen and mammographic breast densities. Cancer Epidemiol Biomarkers Prev 9:911–915.
Spicer DV, Ursin G, Parisky YR, et al (1994) Changes in mammographic densities induced by a hormonal contraceptive designed to reduce breast cancer risk. J Natl Cancer Inst 86:431–436.
Gram IT, Ursin G, Spicer DV, et al (2001) Reversal of gonadotropin-releasing hormone agonist induced reductions in mammographic densities on stopping treatment. Cancer Epidemiol Biomarkers Prev 10:1117–1120.
Meyer F, Brisson J, Morrison AS, et al (1986) Endogenous sex hormones, prolactin, and mammographic features of breast tissue in premenopausal women. J Natl Cancer Inst 77:617–620.
Boyd NF, Stone J, Martin LJ, et al (2002) The association of breast mitogens with mammographic densities. Br J Cancer 87:876–882.
Nebert DW (1993) Elevated estrogen 16α-hydroxylase activity: is this a genotoxic or nongenotoxic biomarker in human breast cancer risk? J Natl Cancer Inst 85:1888–1891.
Bradlow HL, Davis DL, Lin G, et al (1995) Effects of pesticides on the ratio of 16alpha/2-hydroxyestrone: a biologic marker of breast cancer risk. Environ Health Perspect 103(Suppl 7):147–150.
Yager JD, Liehr JG (1996) Molecular mechanisms of estrogen carcinogenesis. Annu Rev Pharmacol Toxicol 36:203–232.
Kabat GC, Chang CJ, Sparano JA, et al (1997) Urinary estrogen metabolites and breast cancer: a case-control study. Cancer Epidemiol Biomarkers Prev 6:505–509.
Ursin G, London S, Stanczyk FZ, et al (1999) Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and risk of breast cancer in postmenopausal women. J Natl Cancer Inst 91:1067–1072.
Fowke JH, Qi D, Bradlow HL, et al (2003) Urinary estrogen metabolites and breast cancer: differential pattern of risk found with pre-versus post-treatment collection. Steroids 68:65–72.
Meilahn EN, De SB, Allen DS, et al (1998) Do urinary oestrogen metabolites predict breast cancer? Guernsey III cohort follow-up. Br J Cancer 78:1250–1255.
Muti P, Bradlow HL, Micheli A, et al (2000) Estrogen metabolism and risk of breast cancer: a prospective study of the 2:16alpha-hydroxyestrone ratio in premenopausal and postmenopausal women. Epidemiology 11:635–640.
Riza E, dos SS, I, De Stavola B, et al (2001) Urinary estrogen metabolites and mammographic parenchymal patterns in postmenopausal women. Cancer Epidemiol Biomarkers Prev 10:627–634.
Adlercreutz H, Gorbach SL, Goldin BR, et al (1994) Estrogen metabolism and excretion in Oriental and Caucasian women. J Natl Cancer Inst 86:1076–1082.
Maskarinec G, Meng L, Ursin G (2001) Ethnic differences in mammographic densities. Int J Epidemiol 30:959–965.
Maskarinec G, Williams AE, Stanczyk FZ, et al (2002) A randomized isoflavone intervention among premenopausal women. Cancer Epidemiol Biomarkers Prev 11:195–201.
Maskarinec G, Robbins C, Riola B, et al (2003) Three measures show high compliance in soy intervention among premenopausal women. J Am Diet Assoc 103:861–866.
Stram DO, Hankin JH, Wilkens LR, et al (2000) Calibration of the dietary questionnaire for a multiethnic cohort in Hawaii and Los Angeles. Am J Epidemiol 151:358–370.
Byng JW, Boyd NF, Fishell E, et al (1994) The quantitative analysis of mammographic densities. Phys Med Biol 39:1629–1638.
Shrout P, Fleiss J (1979) Intraclass correlations: uses in assessing rater reliability. Psychol Bull 86:420–428.
Rinaldi S, Onland-Moret N, Kaaks R, et al (2003) Reproducibility over time of measurements of androgens, estrogens and hydroxy estrogens in urine samples from post-menopausal women. Eur J Epidemiol 18:417–424.
Hawaii Department of Business and Economic Development (2002) 2001 State of Hawaii data book: a statistical abstract. http://www.hawaii.gov/dbedl/db01/index.html. Hawaii Department of Business and Economic Development. 9-19-2002.
Armitage P (1971) Statistical methods in medical research. Blackwell Scientific Publications, Oxford.
SAS OnlineDoc, Version 8 (2002) Cary, NC: SAS Institute Inc.
Ursin G, Ma H, Wu AH et al. (2003) Mammographic density and breast cancerin three ethnic groups. Cancer Epidemiol Biomarkers Prev 12:332–338.
Maskarinec G, Nagata C, Shimizu H, et al (2002) Comparison of mammographic densities and their determinants in women from Japan and Hawaii. Int J Cancer 102:29–33.
Ursin G, London S, Stanczyk FZ, et al (1997) A pilot study of urinary estrogen metabolites (16alpha-OHE1 and 2-OHE1) in postmenopausal women with and without breast cancer. Environ Health Perspect 105Suppl 3:601–605.
Pike MC, Kolonel LN, Henderson BE, et al (2002) Breast cancer in a multiethnic cohort in Hawaii and Los Angeles: risk factor-adjusted incidence in Japanese equals and in Hawaiians exceeds that in whites. Cancer Epidemiol Biomarkers Prev 11:795–800.
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Maskarinec, G., Williams, A.E., Rinaldi, S., Kaaks, R. (2005). Mammographic Densities and Urinary Hormones in Healthy Women with Different Ethnic Backgrounds. In: Li, J.J., Li, S.A., Llombart-Bosch, A. (eds) Hormonal Carcinogenesis IV. Springer, Boston, MA. https://doi.org/10.1007/0-387-23761-5_23
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DOI: https://doi.org/10.1007/0-387-23761-5_23
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