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Chromosomal Instability: A New Paradigm for Estrogen-induced Oncogenesis

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Hormonal Carcinogenesis IV

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References

  1. King M-C, Rowell S, Love SM (1993) Inherited breast and ovarian cancer. What are the risks? What are the choices? J Am Med Assoc 269:1975–1980.

    Article  CAS  Google Scholar 

  2. Clemons M, Gross P (2001) Estrogen and the risk of breast cancer. New Engl J Med 344:276–285.

    Article  PubMed  CAS  Google Scholar 

  3. Toniolo PG (1997) Endogenous estrogens and breast cancer risk. The case for prospective cohort studies. Environ Health Perspect 105:587–601.

    PubMed  Google Scholar 

  4. Felgelson HS, Henderson BE (1996) Estrogens and breast cancer. Carcinogenesis 17:2279–2284.

    Google Scholar 

  5. Adami HO, Persson I, Ekbom A, et al (1995) The aetiology and pathogenesis of human breast cancer. Mutation Res. 333:29–35.

    PubMed  CAS  Google Scholar 

  6. Henderson BE, Ross R, Bernstein L (1988) Estrogens as a cause of human cancer: the Richard and Linda Rosenthal Foundation Award Lecture. Cancer Res 48:246–253.

    PubMed  CAS  Google Scholar 

  7. Rothschild TC, Boylan ES, Calhoon RE, et al. (1987) Transplacental effects of diethylstilbestrol on mammary development and tumorigenesis in female ACI rats. Cancer Res 47:4508–4516.

    PubMed  CAS  Google Scholar 

  8. Hammouche N, Samperez S, Riviere M-R, et al (1982) Estrogen and progesterone receptors in mammary tumors induced in rats by simultaneous administration of 17β-estradiol and progesterone. J Steroid Biochem 17:415–419.

    Article  Google Scholar 

  9. Wu AH, Pike MC, Stram DO (1999) Meta-analysis: Dietary fat intake, serum estrogen levels and the risk of breast cancer. J Natl Cancer Inst 91:529–534.

    Article  PubMed  CAS  Google Scholar 

  10. Sarkola T, Makisal OH, Fakunaga T, et al (1999) Acute effect of alcohol on estradiol, estrone, progesterone, prolactin, cortisol, and luteinizing hormone in premenopausal women. Alcoholism Clin Exp Res 23:976–982.

    Article  CAS  Google Scholar 

  11. Fisher B, Costantino JP, Wickerham DL, et al (1998) Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 90:1371–1388.

    Article  PubMed  CAS  Google Scholar 

  12. Hou X, Li JJ, Chen WB, et al (1996) Estrogen-induced protoncogene and suppressor gene expression in the hamster kidney: Significance for estrogen carcinogenesis. Cancer Res 56:2616–2620.

    PubMed  CAS  Google Scholar 

  13. Li JJ Papa D, Li SA (2003) Ectopic uterine interstitial cell tumors in the hamster kidney. Minerva Endocrinologica 28:321–328.

    PubMed  CAS  Google Scholar 

  14. Li JJ, Papa D, Davis MF, et al (2002) Ploidy differences between hormone-and chemical carcinogen-induced mammary neoplasms: Relation to human breast cancer. Molec Carcinogen 33:56–65.

    Article  CAS  Google Scholar 

  15. Li SA, Weroha SJ, Tawfik O, et al (2002) Prevention of solely estrogen-induced mammary tumors by tamoxifen: Evidence for estrogen receptor mediation. J Endocrinol 175:297–305.

    Article  PubMed  CAS  Google Scholar 

  16. Li JJ, Cuthbertson TL, Li SA (1980) Inhibition of estrogen carcinogenesis in the Syrian golden hamster kidney by antiestrogens. J Natl Cancer Inst 64:795–800.

    PubMed  CAS  Google Scholar 

  17. Butcher RL, Collins WE, Fugo NN (1974) Plasma concentration of LH, FSH, progesterone and estradiol-17β throughout the 4-day estrous cycle of the rat. Endocrinology 94:1704–1708.

    Article  PubMed  CAS  Google Scholar 

  18. Schiff I, Walsh B (1995) Menopause. In: Becker KL (editor) Principles and Practice of Endocrinology and Metabolism, 2nd ed. New York: J.B. Lippincott, 916.

    Google Scholar 

  19. Dorgan JF, Longcope C, Stephenson Jr HE, et al (1997) Serum sex hormone levels are related to breast cancer risk in postmenopausal women. Environ Health Perspect 105:583–585.

    PubMed  Google Scholar 

  20. Kuller LH, Couley JA, Lucas L, et al (1997) Sex steroid hormones, bone mineral density, and risk of breast cancer. Environ Health Perspect 105:593–598.

    PubMed  Google Scholar 

  21. Thijssen JHH, van Landeghem AAJ, Poortman J (1986) Uptake and concentration of steroid hormones in mammary tissues. Ann NY Acad Sci 484:106–116.

    Google Scholar 

  22. Bonney RC, Reed MJ, Davidson K, et al (1983) The relationship between 17β-hydroxysteroid dehydrogenase activity and oestrogen concentrations in human breast tumours and in normal breast tissue. Clin Endocrinol Oxf 19:727–739.

    PubMed  CAS  Google Scholar 

  23. Li JJ, Weroha SJ, Davis MF, et al (2001) Estrogen and progesterone receptors in renomedullary interstitial cells during Syrian hamster estrogen-induced tumorigenesis: Evidence for receptor-mediated oncogenesis. Endocrinology 142:4006–4014.

    Article  PubMed  CAS  Google Scholar 

  24. Gonzalez A, Oberley TD, Li JJ (1989) Morphological and immunohistochemical studies of the estrogen-induced Syrian hamster renal tumor: Probable cell of origin. Cancer Res 49:1020–1028.

    PubMed  CAS  Google Scholar 

  25. Oberley D, Gonzalez A, Lauchner LJ, et al (1991) Characterization of early lesions in estrogen-induced renal tumors in the Syrian hamster. Cancer Res 51:1922–1929.

    PubMed  CAS  Google Scholar 

  26. Gustafsson JA (2000) Novel aspects of estrogen action. J Soc Gynecol Invest 7:58–59.

    Article  Google Scholar 

  27. Harvell DME, Strecher TE, Tochacek M, et al (2000) Rat strain-specifications of 17β-estradiol in the mammary gland: Correlation between estrogen-induced lobulo alveolar hyperplasia and susceptibility to estrogen-induced mammary cancers. Proc Natl Acad Sci USA 97:2779–2784.

    Article  PubMed  CAS  Google Scholar 

  28. Blankenstein MA, Broerse JJ, van Zwieten MJ, et al (1984) Prolactin concentration in plasma and susceptibility to mammary tumors in female rat from different strains treated chronically with estradiol-17β. Breast Cancer Res Treat. 4:137–141.

    Article  PubMed  CAS  Google Scholar 

  29. Blankenstein MA, Broerse JJ, de Vries JB, et al (1977) The effect of subcutaneous administration of oestrogen on plasma oestrogen levels and tumor incidence in female rats. Eur J Cancer 13:1437–1443.

    PubMed  CAS  Google Scholar 

  30. Cutts JH, Noble RL (1964) Estrone-induced mammary tumors in the rat. I. Induction and behavior of tumors. Cancer Res 24:1116–1130.

    PubMed  CAS  Google Scholar 

  31. Dunning WF, Curtis MR, Segaloff A (1952) Strain differences in response to estrone and the induction of mammary gland, adrenal and bladder cancer in rats. Cancer Res 13:147–152.

    Google Scholar 

  32. Nelson WO (1944) The induction of mammary carcinoma in the rat. Yale J Biol Med 17:217–228.

    CAS  Google Scholar 

  33. Sivaraman L, Medina D (2002) Hormone-induced protection against breast cancer. J Mamm Gland Biol Neopl 7:77–92.

    Article  Google Scholar 

  34. Guzman RC, Yang J, Rajkamar L, et al (1999) Hormonal prevention of breast cancer: Mimicking the protective effect of pregnancy. Proc Natl Acad Sci USA 96:2520–2525.

    Article  PubMed  CAS  Google Scholar 

  35. Gammon MD, Neugut AI, Santella RM, et al (2002) The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer. 74:235–254.

    CAS  Google Scholar 

  36. Gammon MD, Wolff MS, Neugut AI, et al (2002) Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in blood. Cancer Epidemiol Biomarkers Prevent 11:686–697.

    CAS  Google Scholar 

  37. Killeen JL, Namiki H (1991) DNA analysis of ductal carcinoma in situ of the breast. A comparison with histologic features. Cancer 68:2602–2607.

    Article  PubMed  CAS  Google Scholar 

  38. Arnerlov C, Emdin SO, Cajander S, et al (2001) Intratumoral variations in DNA ploidy and s-phase fraction in human breast cancer. Anal Cell Path 23:21–28.

    CAS  Google Scholar 

  39. Li JJ, Hou X, Banerjee SK, et al (1999) Overexpression and amplification of c-myc in the Syrian hamster kidney during estrogen carcinogenesis: A probable critical role in neoplastic transformation. Cancer Res 59:2340–2346.

    PubMed  CAS  Google Scholar 

  40. Felscher DW, Bishop JM (1999) Transient excess of Myc activity can elicit genomic instability and tumorigenesis. Proc Natl Acad Sci USA 96:3940–3944.

    Article  Google Scholar 

  41. Mai S, Hanley-Hyde J, Rainey GJ, et al (1999) Chromosomal and extrachromosomal instability of the cyclin D2 gene is induced by Myc overexpression. Neoplasia 1:241–252.

    Article  PubMed  CAS  Google Scholar 

  42. Lingle WL, Barrett SL, Negron VC, et al (2002) Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Adad Sci USA 99:1978–1983

    Article  CAS  Google Scholar 

  43. Lingle WL, Salisbury JL (1999) Altered centrosome structure is associated with abnormal mitoses in human breast cancer. Am J Pathol 155:1941–1951.

    PubMed  CAS  Google Scholar 

  44. Lingle WL, Lutz WH, Ingle JN, et al (1998) Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity. Proc Natl Acad Sci USA 95:2950–2955.

    Article  PubMed  CAS  Google Scholar 

  45. Papa D, Li SA, Li JJ (2003) Comparative genomic hybridization of solely estrogen-induced extopic uterine-like stem cell neoplasms in the hamster kidney: Nonrandom chromosomal alterations. Mol Carcinog 38:97–105.

    Article  PubMed  CAS  Google Scholar 

  46. Spandidos DA, Pintzas A, Kakkanas M, et al (1987) Elevated expression of the myc gene in human benign and malignant breast lesions compared to normal tissue. Anticancer Res 7:1299–1304.

    PubMed  CAS  Google Scholar 

  47. Rummukainen JK, Salminen T, Lundin J, et al (2001) Amplification of c-myc oncogene by chromogenic and fluorescence in situ hybridization in archival breast cancer tissue array samples. Laboratory Invest 11:1545–1551.

    Google Scholar 

  48. Umekita Y, Yoshida H (2000) Cyclin D1 expression in ductal carcinoma in situ, atypical ductal hyperplasia and usual ductal hyperplasia: an immunohistochemical study. Pathol Int 50:527–530.

    Article  PubMed  CAS  Google Scholar 

  49. Weinstat-Saslow, Merino MJ, Manrow RE, et al (1995) Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions. Nature Med 12:1257–1260.

    Article  Google Scholar 

  50. Dutertre S, Decamps S, Prigent C (2002) On the role of aurora-A in centrosome function. Oncogene 21:6175–6183.

    Article  PubMed  CAS  Google Scholar 

  51. Katayama H, Brinkley WR, Sen S (2003) The Aurora kinase: Role in cell transformation and tumorigenesis. Cancer Metast Rev 22:451–464.

    Article  Google Scholar 

  52. Tanaka T, Kimura M, Matsunago K, et al (1999) Centrosomal kinase AIKI is overexpressed in invasive ductal carcinoma of the breast. Cancer Res 59:2041–2044.

    PubMed  CAS  Google Scholar 

  53. Zhou H, Kuang J, Zhong L, et al (1998) Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy, and transformation. Nature Genet 20:189–193.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS, USA

    Jonathan J. Li & Sara Antonia Li

  2. Tumor Biology Program, Mayo Clinic, Rochester, MN, USA

    Jeffrey Salisbury

Authors
  1. Jonathan J. Li
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  2. Jeffrey Salisbury
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  3. Sara Antonia Li
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Editor information

Editors and Affiliations

  1. Division of Etiology and Prevention of Hormonal Cancers, The University of Kansas Medical Center, 3901 Rainbow Boulevard, 2010 Breidenthal, Kansas City, KS, 66160-7417

    Jonathan J. Li (Profesor of Pharmacology, Toxicology and Therapeutics and Director) & Sara A. Li (Associate Research Professor of Pharmacology, Toxicology and Therapeutics) (Profesor of Pharmacology, Toxicology and Therapeutics and Director) &  (Associate Research Professor of Pharmacology, Toxicology and Therapeutics)

  2. Departmento de Patologia, Facultad de Medicina y Odontologia, Camino de Vera s/n, Valencia, 46071, Spain

    Antonio Llombart-Bosch (Director) (Director)

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Li, J.J., Salisbury, J., Li, S.A. (2005). Chromosomal Instability: A New Paradigm for Estrogen-induced Oncogenesis. In: Li, J.J., Li, S.A., Llombart-Bosch, A. (eds) Hormonal Carcinogenesis IV. Springer, Boston, MA. https://doi.org/10.1007/0-387-23761-5_2

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  • DOI: https://doi.org/10.1007/0-387-23761-5_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-23783-1

  • Online ISBN: 978-0-387-23761-9

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