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Hormonal Carcinogenesis IV pp 130–140Cite as

Aromatase Overexpression: Effect of Tissue Estrogen on Phenotypic and Biochemical Changes in Aromatase Transgenic Mice

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Concluding Remarks

Studies summarized herein demonstrate that overexpression of ARO leads to in increased tissue estrogenic activity, induction of MG hyperplastic and dysplastic lesions, gynecomastia, and testicular cancer in male ARO transgenic mice. The preneoplastic lesions induced due to increased tissue estrogenic activity are susceptible to carcinogens. The ARO overexpression-induced MG changes were inhibited with very low letrazole doses, an ARO inhibitor without any effect on normal physiology. The potential clinical importance of this intracrine growth support may provide future clinical and laboratory investigations.

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Author information

Authors and Affiliations

  1. Division of Reproductive Research, Department of Obstetrics and Gynecology, The University of Texas Health Science Center, San Antonio, TX, USA

    Rajeshwar Rao Tekmal

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  1. Rajeshwar Rao Tekmal
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  2. Nameer Kirma
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  3. Usha Mandava
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  4. Roopa Luthra
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Editor information

Editors and Affiliations

  1. Division of Etiology and Prevention of Hormonal Cancers, The University of Kansas Medical Center, 3901 Rainbow Boulevard, 2010 Breidenthal, Kansas City, KS, 66160-7417

    Jonathan J. Li (Profesor of Pharmacology, Toxicology and Therapeutics and Director) & Sara A. Li (Associate Research Professor of Pharmacology, Toxicology and Therapeutics) (Profesor of Pharmacology, Toxicology and Therapeutics and Director) &  (Associate Research Professor of Pharmacology, Toxicology and Therapeutics)

  2. Departmento de Patologia, Facultad de Medicina y Odontologia, Camino de Vera s/n, Valencia, 46071, Spain

    Antonio Llombart-Bosch (Director) (Director)

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Tekmal, R.R., Kirma, N., Mandava, U., Luthra, R. (2005). Aromatase Overexpression: Effect of Tissue Estrogen on Phenotypic and Biochemical Changes in Aromatase Transgenic Mice. In: Li, J.J., Li, S.A., Llombart-Bosch, A. (eds) Hormonal Carcinogenesis IV. Springer, Boston, MA. https://doi.org/10.1007/0-387-23761-5_11

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  • DOI: https://doi.org/10.1007/0-387-23761-5_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-23783-1

  • Online ISBN: 978-0-387-23761-9

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