7. Conclusion
Different stimuli regulate phosphorylation of the cotransporter by activating or inhibiting distinct sets of cotransporter kinases and phosphatases, resulting in distinct patterns of phosphorylation. Phosphorylation of these sites may have a profound direct effect on transport rate, but this is not always the case. Phosphorylation may also determine how the transporter interacts with other regulatory proteins, perhaps helping the cell to integrate cotransporter activity in response to different, possibly conflicting, stimuli.
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Flatman, P.W. (2004). Regulation of Na-K-2Cl Cotransport in Red Cells. In: Lauf, P.K., Adragna, N.C. (eds) Cell Volume and Signaling. Advances in Experimental Medicine and Biology, vol 559. Springer, Boston, MA . https://doi.org/10.1007/0-387-23752-6_7
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