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Cell Volume and Signaling pp 391–392Cite as

K-Cl Cotransport (K-Cl COT, KCC) Activation by N-Ethylmaleimide in C6 Glioma Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 559))

1. Abstract

Astrocytes make up greater than 50% of the cell population of the mammalian central nervous system and provide both structural and functional support to the neuronal population. Reverse transcriptase polymerase chain reaction1, protein immunoblotting,2 and immunohistochemical evidence3 indicate the presence of both Na-K-2Cl cotransporter (COT) and K-Cl COT in astrocytes. Of the four known isoforms of the K-Cl COT, only KCC1 is present in C6 glioma cells.4

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References

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Author information

Authors and Affiliations

  1. Pathology Dept., Wright State University, Dayton, OH, 45435

    Kenneth B. E. Gagnon & Peter K. Lauf

  2. Pharmacology & Toxicology Dept., Wright State University, Dayton, OH, 45435

    Norma C. Adragna

  3. Anatomy & Physiology Dept., Wright State University, Dayton, OH, 45435

    Robert E. W. Fyffe

Authors
  1. Kenneth B. E. Gagnon
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  2. Norma C. Adragna
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  3. Robert E. W. Fyffe
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  4. Peter K. Lauf
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Editor information

Editors and Affiliations

  1. Wright State University, Dayton, Ohio

    Peter K. Lauf  & Norma C. Adragna  & 

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© 2004 Springer Science+Business Media, Inc.

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Gagnon, K.B.E., Adragna, N.C., Fyffe, R.E.W., Lauf, P.K. (2004). K-Cl Cotransport (K-Cl COT, KCC) Activation by N-Ethylmaleimide in C6 Glioma Cells. In: Lauf, P.K., Adragna, N.C. (eds) Cell Volume and Signaling. Advances in Experimental Medicine and Biology, vol 559. Springer, Boston, MA . https://doi.org/10.1007/0-387-23752-6_40

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