Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
11. References
E. K. Hoffmann and L. O. Simonsen, Membrane mechanisms in volume and pH regulation in vertebrate cells, Physiol Rev 69, 315–382 (1989).
F. Lang, G. L. Busch, M. Ritter, H. Volkl, S. Waldegger, E. Gulbins, and D. Haussinger, Functional significance of cell volume regulatory mechanisms, Physiol Rev 78(1), 247–306 (1998).
A. A. Mongin, S. N. Orlov, Mechanisms of cell volume regulation and possible nature of the cell volume sensor, Pathophysiology 8(2), 77–88 (2001).
T. G. Cotter, S. V. Lennon, J. G. Glynn, and S. J. Martin, Cell death via apoptosis and its relation to growth, development and differentiation of both tumor and normal cells., Anticancer Res 10(5A), 1153–1160 (1990).
E. Duvall, A. H. Wyllie, Death and the cell, Immunol Today 7, 115–119 (1986).
D. L. Vaux, A. Strasser, The molecular biology of apoptosis, Proc Natl Acad Sci USA 93, 2239–2244 (1996).
R. Wadhwa, O. M. Pereira-Smith, R. R. Reddel, Y. Sugimoto, Y. Mitsui, and S. C. Kaul, Correlation between complementation group for immortality and the cellular distribution of mortalin, Exp Cell Res 216(1), 101–106 (1995).
A. H. Wyllie, The 1992 Frank Rose memorial lecture, Br J Cancer 67, 205–208 (1993).
J. F. R. Kerr, A. H. Wyllie, and A. R. Currie, Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics., Br J Cancer 26, 239–257 (1972).
L. B. Jordan, D. J. Harrison, Apoptosis: a distinctive form of cell death, in: Apoptosis in Cardiac Biology, edited by H. Schunkert, G. A. J. Riegger (Kluwer Academic Publishers, Boston-Dordrecht-London, 1999), pp. 124–135.
L. F. Barros, T. Hermosilla, and J. Castro, Necrotic volume increase and the early physiology of necrosis, Comp Biochem Physiol A Mol Integr Physiol 130(3), 401–409 (2001).
C. D. Bortner, J. A. Cidlowski, Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes, Am J Physiol 271, C950–C961 (1996).
C. D. Bortner, J. A. Cidlowski, A necessary role for cell shrinkage in apoptosis, Biochem Pharmacol 56, 1549–1559 (1998).
Y. Okada, E. Maeno, T. Shimizu, K. Dezaki, J. Wang, and S. Morishima, Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD), J Physiol 532 (Pt 1), 3–16 (2001).
S. N. Orlov, T. V. Dam, J. Tremblay, and P. Hamet, Apoptosis in vascular smooth muscle cells: role of cell shrinkage, Biochem Biophys Res Commun 221(3), 708–715 (1996).
G. I. Evan, A. H. Wyllie, C. S. Gilbert, T. D. Littlewood, H. Land, M. Brooks, C. M. Waters, L. Z. Penn, and D. C. Hancock, Induction of apoptosis in fibroblasts by c-myc protein, Cell 69(1), 119–128 (1992).
M. R. Bennett, G. I. Evan, and A. C. Newby, Deregulated expression of the c-myc oncogene abolishes inhibition of proliferation of rat vascular smooth muscle cells by serum reduction, interferon-, heparin, and cyclic nucleotide analogues and induces apoptosis., Circ Res 74, 525–536 (1994).
M. R. Bennett, G. I. Evan, and S. M. Schwartz, Apoptosis of rat vascular smooth muscle cells is regulated by p53 dependent and independent pathways., Circ Res 77, 266–273 (1995).
S. N. Orlov, D. Pchejetski, S. Taurin, N. Thorin-Trescases, G. V. Maximov, A. V. Pshezhetsky, A. B. Rubin, and P. Hamet, Apoptosis in serum-deprived vascular smooth muscle cells: evidence for cell volumeindependent mechanism, Apoptosis 9, 55–56 (2004).
S. N. Orlov, N. Thorin-Trescases, T. V. Dam, M. A. Fortuno, N. O. Dulin, J. Tremblay, and P. Hamet, Activation of cAMP signaling transiently inhibits apoptosis in vascular smooth cells in a site upstream of caspase-3, Cell Death Differ 6(7), 661–672 (1999).
S. N. Orlov, N. Thorin-Trescases, S. V. Kotelevtsev, J. Tremblay, and P. Hamet, Inversion of the intracellular Na+/K+ ratio blocks apoptosis in vascular smooth muscle at a site upstream of caspase-3, J Biol Chem 274(23), 16545–16552 (1999).
M. R. Bennett, K. MacDonald, S.-W. Chan, J. P. Luzio, R. Simari, and P. Weissberg, Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis, Science 282, 290–293 (1998).
S. N. Orlov, D. Pchejetski, S. Der Sarkissian, V. A. Adarichev, S. Taurin, A. V. Pshezhetsky, J. Tremblay, G. V. Maximov, D. deBlois, M. R. Bennett, and P. Hamet, [3H]Thymidine labelling of DNA triggers apoptosis potentiated by E1A-adenoviral protein, Apoptosis 8, 199–208 (2003).
N. K. Isaev, E. V. Stelmashook, A. Halle, C. Harms, M. Lautenschlager, M. Weih, U. Dirnagl, I. V. Victorov, and D. B. Zorov, Inhibition of Na(+),K(+)-ATPase activity in cultured rat cerebellar granule cells prevents the onset of apoptosis induced by low potassium, Neurosci Lett 283(1), 41–44 (2000).
X. Zhou, G. Jiang, A. Zhao, T. Bondeva, P. Hirszel, and T. Balla, Inhibition of Na,K-ATPase activates PI3 kinase and inhibits apoptosis in LLC-PK1 cells, Biochem Biophys Res Commun 285(1), 46–51 (2001).
S. N. Orlov, S. Taurin, N. Thorin-Trescases, N. O. Dulin, J. Tremblay, and P. Hamet, Inversion of the intracellular Na+/K+ ratio blocks apoptosis in vascular smooth muscle cells by induction of RNA synthesis, Hypertension 35(5), 1062–1068 (2000).
S. N. Orlov, S. Taurin, J. Tremblay, and P. Hamet, Inhibition of Na+-K+ pump affects nucleic acid synthesis and smooth muscle cell proliferation via elevation of the [Na+]i/[K+]i ratio: possible implication in vascular remodelling, J Hypertens 19, 1559–1565 (2001).
S. Taurin, V. Seyrantepe, S. N. Orlov, T. L. Tremblay, P. Thibault, M. R. Bennett, P. Hamet, and A. V. Pshezhetsky, Proteome analysis and functional expression identify mortalin as an antiapoptotic gene induced by elevation of [Na+]i/[K+]i ratio in cultured vascular smooth muscle cells, Circ Res 91(10), 915–922 (2002).
S. Takano, R. Wadhwa, Y. Yoshii, T. Nose, S. C. Kaul, and Y. Mitsui, Elevated level of mortalin expression in human brain tumors, Exp Cell Res 237(1), 38–45 (1997).
R. Wadhwa, S. Takano, Y. Mitsui, and S. C. Kaul, NIH 3T3 cells malignantly transformed by mot-2 show inactivation and cytoplasmic sequestration of the p53 protein, Cell Res 9(4), 261–269 (1999).
R. Wadhwa, S. Takano, M. Robert, A. Yoshida, H. Nomura, R. R. Reddel, Y. Mitsui, and S. C. Kaul, Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member, J Biol Chem 273(45), 29586–29591 (1998).
S. Taurin, P. Hamet, and S. N. Orlov, Na/K pump and intracellular monovalent cations: novel mechanism of excitation-transcription coupling involved in inhibition of apoptosis, Mol Biol 37(3), 371–381 (2003).
Z. Xie, A. Askari, Na+/K+-ATPase as a signal transducer, Eur J Biochem 269, 2434–2439 (2003).
Y. Nakagawa, E. F. Petricoin, H. Akai, P. M. Grimley, B. Rupp, and A. C. Larner, Interferon-alpha-induced gene expression: evidence for a selective effect on activation of the ISGF3 transcription complex, Virology 190, 210–220 (1992).
Y. Nakagawa, V. Rivera, and A. C. Larner, A role for the Na/K-ATPase in the control of human c-fos and c-jun transcription, J Biol Chem 267(13), 8785–8788 (1992).
S. Numazawa, N. Inoue, H. Nakura, T. Sugiyama, E. Fujino, M. Shinoki, T. Yoshida, and Y. Kuroiwa, A cardiotonic steroid bufalin-induced differentiation of THP-1 cells. Involvement of Na+,K(+)-ATPase inhibition in the early changes in proto-oncogene expression, Biochem Pharmacol 52(2), 321–329 (1996).
M. Joannidis, L. G. Cantley, K. Spokes, A. K. Stuart-Tilley, S. L. Alper, and F. H. Epstein, Modulation of c-fos and egr-1 expression in the isolated perfused kidney by agents that alter tubular work, Kidney Int 52(1), 130–139 (1997).
M. Peng, L. Huang, Z. Xie, W. H. Huang, and A. Askari, Partial inhibition of Na+/K+-ATPase by ouabain induces the Ca2+-dependent expressions of early-response genes in cardiac myocytes, J Biol Chem 271(17), 10372–10378 (1996).
Z. Xie, P. Kometiani, J. Liu, J. I. Shapiro, and A. Askari, Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes, J Biol Chem 274, 19323–19328 (1999).
S. Taurin, N. O. Dulin, D. Pchejetski, R. Grygorczyk, J. Tremblay, P. Hamet, and S. N. Orlov, c-Fos expression in ouabain-treated vascular smooth muscle cells from rat aorta: evidence for an intracellularsodium-mediated, calcium-independent mechanism, J Physiol 543 (Pt 3), 835–847 (2002).
D. Pchejetski, S. Taurin, S. Der Sarkissian, O. D. Lopina, A. V. Pshezhetsky, J. Tremblay, D. deBlois, P. Hamet, and S. N. Orlov, Inhibition of Na+-K+-ATPase by ouabain triggers epithelial cell death independently of inversion of the [Na+]i/[K+]i ratio, Biochem Biophys Res Commun 301, 735–744 (2003).
A. D. C. Macknight, A. Leaf, Regulation of cell volume, Physiol Rev 57, 510–573 (1977).
T. Akera, Y.-C. Ng, I. S. Shien, E. Bero, T. M. Brody, and W. E. Braselton, Effects of K+ on the interaction between cardiac glycosides and Na,K-ATPase, Eur J Pharmacol 111, 147–157 (1985).
J. B. Lingrel, M. L. Croyle, and J. M. Argüello, Ligand binding sites of Na,K-ATPase, Acta Physiol Scand 163(Suppl. 643), 69–77 (1998).
E. T. Wallick, A. Schwartz, Interaction of cardiac glycosides with Na+-K+-ATPase, Methods in Enzymology 156, 201–213 (1988).
A. M. Malek, G. G. Goss, L. Jiang, S. Izumo, and S. L. Alper, Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells, Stroke 29(12), 2631–2640 (1998).
L. Michea, D. R. Ferguson, E. M. Peters, P. M. Andrews, M. R. Kirby, and M. B. Burg, Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells, Am J Physiol Renal Physiol 278(2), F209–F218 (2000).
A. J. Bilney, A. W. Murray, Pro-and anti-apoptotic effects of K+ in HeLa cells, FEBS Lett 424(3), 221–224 (1998).
C. C. Matthew, E. L. Feldman, Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cell from hyperosmotic induced programmed cell death, J Cell Physiol 166, 323–331 (1996).
S. Wesselborg, D. Kaberlitz, Activation-driven death of human T cell clones: time course kinetics of the induction of cell shrinkage, DNA fragmentation, and cell death, Cell Immunol 148(1), 234–241 (1993).
E. Maeno, Y. Ishizaki, T. Kanaseki, A. Hazama, and Y. Okada, Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis, Proc Natl Acad Sci USA 97, 9487–9492 (2000).
H. Ohyama, T. Yamada, and I. Watanabe, Cell volume reduction associated with interphase death in rat thymocytes, Radiat Res 85, 333–339 (1981).
C. D. Bortner, J. A. Cidlowski, Caspase independent/dependent regulation of K+, cell shrinkage and mitochondrial membrane potential during lymphocyte apoptosis, J Biol Chem 274, 21953–21962 (1999).
C. D. Bortner, F. M. Hughes, and J. A. Cidlowski, A primary role for K+ and Na+ efflux in activation of apoptosis, J Biol Chem 272, 32436–32442 (1997).
C. S. I. Nobel, J. K. Aronson, D. J. van den Dobbelsteen, and A. F. G. Slater, Inhibition of Na+/K+-ATPase may be one mechanism contributing to potassium efflux and cell shrinkage in CD995-induced apoptosis, Apoptosis 5(2), 153–163 (2000).
S. N. Orlov, J. Tremblay, and P. Hamet, Cell volume in vascular smooth muscle cells is regulated by bumetanide-sensitive ion transport., Am J Physiol 270, C1388–C1397 (1996).
R. S. Benson, S. Heer, C. Dive, and A. J. Watson, Characterization of cell volume loss in CEM-C7A cells during dexamethasone-induced apoptosis, Am J Physiol 270, C1190–C1203 (1996).
A. Y. Xiao, L. Wei, S. Xia, S. Rothman, and S. P. Yu, Ionic mechanism of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurones, J Neurosci 22, 1350–1362 (2002).
M. Gomez-Angelats, C. D. Bortner, and J. A. Cidlowski, Protein kinase C (PKC) inhibits Fas receptorinduced apoptosis through modulation of the loss of K+ and cell shrinkage, J Biol Chem 275, 19609–19619 (2000).
F. M. Hughes, C. D. Bortner, G. D. Purdy, and J. A. Cidlowski, Intracellular K+ suppresses the activation of apoptosis in lymphocytes, J Biol Chem 272, 30567–30576 (1997).
G. Barbiero, F. Duranti, G. Bonelli, J. S. Amenta, and F. M. Baccino, Intracellular ionic variations in the apoptotic death of cells by inhibitors of cell cycle progression, Exp Cell Res 217, 410–418 (1995).
A. Minta, R. Y. Tsien, Fluorescent indicators for cytosolic sodium, J Biol Chem 264, 19449–19457 (1989).
L. V. Colom, M. E. Diaz, D. R. Beers, A. Neely, W. J. Xie, and S. H. Appel, Role of potassium in amyloidinduced cell death, J Neurochem 70, 1925–1934 (1998).
S. Krick, O. Platoshyn, M. Sweeney, H. Kim, and J. X. J. Yuan, Activation of K+ channels induces apoptosis in vascular smooth muscle cells, Am J Physiol 280, C970–C979 (2001).
H. H. Nietsch, M. W. Roe, J. F. Fiekers, A. L. Moore, and S. D. Lidofsky, Activation of potassium and chloride channels by tumor necrosis factor α, J Biol Chem 275, 20556–20561 (2000).
L. Wang, D. Xu, W. Dai, and L. Lu, An ultraviolet-activated K+ channel mediates apoptosis of myeloblastic leukemia cells, J Biol Chem 274, 3678–3685 (1999).
S. P. Yu, C. H. Yeh, S. L. Sensi, B. J. Gwag, L. M. Canzoniero, Z. S. Farhangrazi, H. S. Ying, M. Tian, L. L. Dugan, and D. W. Choi, Mediation of neuronal apoptosis by enhancement of outward potassium current, Science 278(5335), 114–117 (1997).
M. J. Mann, V. J. Dzau, Therapeutic applications of transcription factor decoy oligonucleotides, J Clin Invest 106, 1071–1075 (2000).
I. Szabo, E. Gulbins, H. Apfel, X. Zhang, P. Barth, A. E. Busch, K. Schlottmann, O. Pongs, and F. Lang, Tyrosine phosphorylation-dependent suppression of a voltage-gated K+ channel in T lymphocytes upon Fas stimulation, J Biol Chem 271, 20465–20469 (1996).
E. Gulbins, I. Szabo, K. Baltzer, and F. Lang, Ceramide-induced inhibition of T-lymphocyte voltage gated potassium channel is mediated by tyrosine kinases, Proc Natl Acad Sci USA 94, 7661–7666 (1997).
R. A. Gottlieb, A. Dosanjih, Mutant cystic fibrosis transmembrane conductance regulator inhibits acidification and apoptosis in C127 cells: possible relevance to cystic fibrosis, Proc Natl Acad Sci USA 93, 3587–3591 (2001).
I. Szabo, A. Lepple-Wienhues, K. N. Kaba, M. Zoratti, E. Gulbins, and F. Lang, Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T-lymphocytes, Proc Natl Acad Sci USA 95, 6169–6174 (1998).
K. S. Lang, C. Duranton, H. Poehlmann, S. Myssina, C. Bauer, F. Lang, T. Wieder, and S. M. Huber, Cation channels trigger apoptotic death of erythrocytes, Cell Death Differ 10(2), 249–256 (2003).
H. Pasantes-Morales, R. M. del Rio, Taurine and mechanisms of cell volume regulation, in: Taurine: Functional Neurochemistry, Physiology and Cardiology, edited by R. Cohen (Wiley-Liss Inc., New York, 1990), pp. 317–328.
F. Lang, J. Madlung, A. C. Uhlemann, T. Risler, and E. Gulbins, Cellular taurine release triggered by stimulation of the FAS (CD95) receptor in Jurkat lymphocytes, Pflugers Arch 436(3), 377–383 (1998).
J. Moran, X. Hernandez-Pech, H. Merchant-Larios, and H. Pasantes-Morales, Release of taurine in apoptotic cerebellar granule neurones in culture, Pflugers Arch 439(3), 271–277 (2000).
Q. D. Wu, J. H. Wang, F. Fennesy, H. P. Redmond, and D. Bouchier-Hayes, Taurine prevents highglucose-induced human vascular endothelial cell apoptosis, Am J Physiol 277, C1229–C1238 (1999).
J. B. Smith, M. B. Wade, N. S. Fineberg, and M. H. Weinberger, Influence of race, sex, and blood pressure on erythrocyte sodium transport in humans, Hypertension 12(3), 251–258 (1988).
F. Beauvais, L. Michel, and L. Dubertret, Human eosinophils in culture undergo a striking and rapid shrinkage during apoptosis, J Leukoc Biol 57, 851–855 (1995).
B. Dallaporta, P. Marchetti, M. A. de Pablo, C. Maisse, H. T. Duc, D. Métivier, N. Zamzani, M. Geuskens, and G. Kroemer, Plasma membrane potential in thymocyte apoptosis, J Immunol 162, 6534–6542 (1999).
P. A. Doris, Abnormalities of sodium pump function in hypertension and the role of endogenous cardiotonic steroids, Cell Mol Biol 47(2), 391–401 (2001).
E. Berendes, P. Cullen, H. van Aken, W. Zidek, M. Erren, M. Hubschen, T. Weber, S. Wirtz, M. Tepel, and M. Walter, Endogenous glycosides in critically ill patients, Crit Care Med 31, 1331–1337 (2003).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Springer Science+Business Media, Inc.
About this paper
Cite this paper
Orlov, S.N., Hamet, P. (2004). Apoptosis VS. Oncosis: Role of Cell Volume and Intracellular Monovalent Cations. In: Lauf, P.K., Adragna, N.C. (eds) Cell Volume and Signaling. Advances in Experimental Medicine and Biology, vol 559. Springer, Boston, MA . https://doi.org/10.1007/0-387-23752-6_21
Download citation
DOI: https://doi.org/10.1007/0-387-23752-6_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-23299-7
Online ISBN: 978-0-387-23752-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)