Skip to main content

Volume Activated Anion Channel and Astrocytic Cellular Edema in Traumatic Brain Injury and Stroke

  • Conference paper

Part of the book series: Advances in Experimental Medicine and Biology ((volume 559))

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   149.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

5. References

  1. O. Devuyst and W.B. Guggino, Chloride channels in the kidney: lessons learned from knockout animals, Am. J. Physiol Renal Physiol. 283, F1176–F1191 (2002).

    PubMed  CAS  Google Scholar 

  2. A.D. Maher and P.W. Kuchel, The Gardos channel: a review of the Ca 2+-activated K+ channel in human erythrocytes, Int. J. Biochem. Cell Biol. 35, 1182–1197 (2003

    Article  PubMed  CAS  Google Scholar 

  3. P. Calabresi, L.M. Cupini, D. Centonze, F. Pisani and G. Bernardi, Antiepileptic drugs as a possible neuroprotective strategy in brain ischemia, Ann. Neurol. 53, 693–702 (2003).

    Article  PubMed  CAS  Google Scholar 

  4. B. Nilius and G. Droogmans, Amazing chloride channels: an overview, Acta Physiol Scand. 177, 119–147 (2003).

    Article  PubMed  CAS  Google Scholar 

  5. B. Nilius, J. Eggermont, T. Voets, G. Buyse, V. Manolopoulos and G. Droogmans, Properties of volume-regulated anion channels in mammalian cells, Prog. Biophys. Mol. Biol. 68, 69–119 (1997).

    Article  PubMed  CAS  Google Scholar 

  6. T. J. Jentsch, V. Stein, F. Weinreich and A.A. Zdebik, Molecular structure and physiological function of chloride channels, Physiol Rev. 82, 503–568 (2002).

    PubMed  CAS  Google Scholar 

  7. K. Strange, F. Emma and P.S. Jackson, Cellular and molecular physiology of volume-sensitive anion channels, Am. J. Physiol. Cell Physiol. 270, C711–C730 (1996).

    CAS  Google Scholar 

  8. K. Tuz, B. Ordaz, L. Vaca, O. Quesada and H. Pasantes-Morales, Isovolumetric regulation mechanisms in cultured cerebellar granule neurons, J. Neurochem. 79, 143–151 (2001).

    Article  PubMed  CAS  Google Scholar 

  9. M.E. Chamberlin and K. Strange, Anisosmotic cell volume regulation: a comparative view, Am. J. Physiol. 257, C159–C173 (1989).

    PubMed  CAS  Google Scholar 

  10. L.R. Nelson, R.S. Bourke, A.J. Popp, J. Cragoe, A. Signorelli, V.V. Foster and W. Creel, Evaluation of treatment modalities in severe head injuries using an animal model, in “Neural Trauma” (A.J. Popp, R.S. Bourke, L.R. Nelson and H.K. Kimelberg, Eds.), Raven Press, New York (1979).

    Google Scholar 

  11. R. Bullock, W.L. Maxwell, D.I. Graham, G.M. Teasdale and J.H. Adams, Glial swelling following cerebral contusion: an ultrastructural study, J. Neurology, Neurosurgery and Psychiatry 54, 427–434 (1991).

    Article  CAS  Google Scholar 

  12. K.D. Barron, M.P. Dentinger, H.K. Kimelberg, L.R. Nelson, R.S. Bourke, S. Keegan, R. Mankes and E.J. Cragoe, J., Ultrastructural features of a brain injury model in cat. I. Vascular and neuroglial changes and the prevention of astroglial swelling by a fluorenyl (aryloxy) alkanoic acid derivative (L-644, 711), Acta Neuropathol. (Berl.) 75, 295–307 (1988).

    Article  CAS  Google Scholar 

  13. Y. Matsushita, K. Shima, H. Nawashiro and K. Wada, Real-time monitoring of glutamate following fluid percussion brain injury with hypoxia in the rat, J. Neurotrauma 17, 143–153 (2000).

    Article  PubMed  CAS  Google Scholar 

  14. E.J. Cragoe, Jr, Drugs for the treatment of traumatic brain injury, Med. Res. Rev. 7, 271–305 (1987).

    Article  PubMed  CAS  Google Scholar 

  15. E.J. Cragoe, Jr, N.P. Gould, O.W. Woltersdorf, Jr, C. Ziegler, R.S. Bourke, L.R. Nelson, H.K. Kimelberg, J.B. Waldman, A.J. Popp and N. Sedransk, Agents for the treatment of brain injury. 1. (Aryloxy)alkanoic acids, J. Med. Chem. 25, 567–579 (1982).

    Article  PubMed  CAS  Google Scholar 

  16. E.J. Cragoe, Jr, O.W. Woltersdorf, Jr, N.P. Gould, A.M. Pietruszkiewicz, C. Ziegler, Y. Sakurai, G.E. Stokker, P.S. Anderson, R.S. Bourke, H.K. Kimelberg, L.R. Nelson, K.D. Barron, J.E. Rose, D. Szarowski, A.J. Popp and J.B. Waldman, Agents for the treatment of brain edema. 2. [2,3,9,9a-Tetrahydro-3-oxy-substituted-1 H-fluoren-7-yl) oxyalkanoic acids and some of their analogues, J. Med. Chem. 29, 825–841 (1986).

    Article  PubMed  CAS  Google Scholar 

  17. H.K. Kimelberg, J.W. Rose, K.D. Barron, R.A. Waniewski and E.J. Cragoe, Jr, Astrocytic swelling in head injury: beneficial effects of an inhibitor of anion exchange transport and glutamate uptake in glial cells, Molec. Chem. Neuropathol. 11, 1–31 (1989).

    Article  CAS  Google Scholar 

  18. H.K. Kimelberg, E.J. Cragoe, Jr, L.R. Nelson, A.J. Popp, D. Szarowski, J.W. Rose, O.W. Woltersdorf, Jr and A.M. Pietruszkiewicz, Improved recovery from a traumatic-hypoxic brain injury in cats by intracisternal injection of an anion transport inhibitor, Cent. Nerv. Syst. Trauma. 4, 3–14 (1987).

    PubMed  CAS  Google Scholar 

  19. J.H. Garcia, H. Kalimo, Y. Kamijyo and B.F. Trump, Cellular events during partial cerebral ischemia. I. Electron microscopy of feline cerebral cortex after middle-cerebral-artery occlusion, Virchow’s Arch. B Cell Path. 25, 191–206 (1977).

    CAS  Google Scholar 

  20. K.F. Liu, F.H. Li, T. Tatlisumak, J.H. Garcia, C.H. Sotak, M. Fisher and J.D. Fenstermacher, Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia, Stroke 32, 1897–1905 (2001).

    PubMed  CAS  Google Scholar 

  21. M.D. Silva, T. Omae, K.G. Helmer, F. Li, M. Fisher and C.H. Sotak, Separating changes in the intra-and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain, Magn Reson. Med. 48, 826–837 (2002).

    Article  PubMed  Google Scholar 

  22. T.Q. Duong, J.V. Sehy, D.A. Yablonskiy, B.J. Snider, J.J. Ackerman and J.J. Neil, Extracellular apparent diffusion in rat brain, Magn Reson. Med. 45, 801–810 (2001).

    Article  PubMed  CAS  Google Scholar 

  23. T. Pearson and B.G. Frenguelli, Volume-regulated anion channels do not contribute extracellular adenosine during the hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus, Eur. J. Neurosci. 12, 3064–3066 (2000).

    Article  PubMed  CAS  Google Scholar 

  24. A. Biegon, M. Brewster, H. Degani, E. Pop, D. Somjen and A.M. Kaye, A permanently charged tamoxifen derivative idsplays anticancer activity and improved tissue selectivity in rodents., Cancer Res. 56, 4328–4331 (1996).

    PubMed  CAS  Google Scholar 

  25. Y. Seki, P.J. Feustel, R.W. Keller, Jr, B.I. Tranmer and H.K. Kimelberg, Inhibition of ischemia-induced glutamate release in rat striatum by dihydrokainate and an anion channel blocker, Stroke 30, 433–440 (1999).

    PubMed  CAS  Google Scholar 

  26. H.K. Kimelberg, Cell volume in the CNS: Regulation and implications for nervous system function and pathology, The Neuroscientist 6, 13–24 (2000).

    Google Scholar 

  27. P.J. Feustel, Y. Jin, and H.K. Kimelberg, Volume regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbra. Stroke, in press (2004).

    Google Scholar 

  28. E.-M. Rutledge, M. Aschner and H.-K. Kimelberg, Pharmacological characterization of swelling-induced D-[3H]aspartate release from primary astrocyte cultures, Am. J. Physiol.: Cell Physiol. 274, C1511–C1520 (1998).

    CAS  Google Scholar 

  29. H.K. Kimelberg, P.J. Feustel, Y. Jin, J. Paquette, A. Boulos, R.W. Keller and B.I. Tranmer, Acute treatment with tamoxifen reduces ischemic damage following middle cerebral artery occlusion, Neuro Report 11, 2675–2679 (2000).

    CAS  Google Scholar 

  30. H.K. Kimelberg, Y. Jin and P.J. Feustel, Neuroprotective activity of tamoxifen in permanent focal ischemia, J. Neurosurgery 99, 138–142 (2003).

    CAS  Google Scholar 

  31. D.W. Choi, Excitotoxic cell death, J.Neurobiol. 23, 1261–1276 (1992).

    Article  PubMed  CAS  Google Scholar 

  32. M.D. Ginsberg, Neuroprotection in brain ischemia: an update I. The Neuroscientist 1, 95–103 (1995).

    Google Scholar 

  33. M.D. Ginsberg, Neuroprotection in brain ischemia: an update II. The Neuroscientist 1, 164–175 (1995).

    Google Scholar 

  34. M.D. Ginsberg, Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection. Tthe 2002 Thomas Willis lecture, Stroke 34, 214–223 (2003).

    Article  PubMed  Google Scholar 

  35. J.A. Hartings, M.L. Rolli, X.C. Lu and F.C. Tortella, Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection, J.Neurosci. 23, 11602–11610 (2003).

    PubMed  CAS  Google Scholar 

  36. S.B. DeBow, D.L. Clark, C.L. MacLellan and F. Colbourne, Incomplete assessment of experimental cytoprotectants in rodent ischemia studies, Can. J. Neurol. Sci. 30, 368–374 (2003).

    PubMed  Google Scholar 

  37. D.J. Gladstone, S.E. Black and A.M. Hakim, Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions, Stroke 33, 2123–2136 (2002).

    Article  PubMed  Google Scholar 

  38. N. Decher, H.J. Lang, B. Nilius, A. Bruggemann, A.E. Busch and K. Steinmeyer, DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration, Br. J. Pharmacol 134, 1467–1479 (2001).

    Article  PubMed  CAS  Google Scholar 

  39. L.R. Nelson, E.L. Auen, R.S. Bourke, K.D. Barron, A.B. Malik, J. Cragoe, A.J. Popp, J.B. Waldman, H.K. Kimelberg, V.V. Foster, W. Creel and L. Schuster, Comparison of animal head injury models developed for treatment modality evaluation, in “Head Injury: Basic and Clinical Aspects” (R.G. Grossman and P.L. Gildenberg, Eds.), Raven Press, New York (1982).

    Google Scholar 

  40. R.S. Bourke, J.B. Waldman, H.K. Kimelberg, K.D. Barron, B.D. San Filippo, A. J. Popp and L.R. Nelson, Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with total inhibition by a non-diuretic acylaryloxyacid derivative, J. Neurosurgery 55, 364–370 (1981).

    Article  CAS  Google Scholar 

  41. S.H. Mehta, K.M. Dhandapani, L.M. De Sevilla, R.C. Webb, V.B. Mahesh and D. W. Brann, Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat, Neuroendocrinol. 77, 44–50 (2003).

    Article  CAS  Google Scholar 

  42. J.I. MacGregor and V.C. Jordan, Basic Guide to the Mechanisms of Antiestrogen Action, Pharmacological Reviews 50, 151–196 (1998).

    PubMed  CAS  Google Scholar 

  43. N.J. Alkayed, S. Goto, N. Sugo, H.D. Joh, J. Klaus, B.J. Crain, O. Bernard, R.J. Traystman and P.D. Hurn, Estrogen and Bcl-2: gene induction and effect of transgene in experimental stroke, J. Neurosci. 21, 7543–7550 (2001).

    PubMed  CAS  Google Scholar 

  44. P.D. Hurn and L.M. Brass, Estrogen and stroke: a balanced analysis, Stroke 34, 338–341 (2003).

    Article  PubMed  Google Scholar 

  45. H. Wiseman, Tamoxifen: new membrane-mediated mechanisms of action and therapeutic advances, Trends Pharmacol Sci 15, 83–89 (1994).

    Article  PubMed  CAS  Google Scholar 

  46. K. Osuka, P.J. Feustel, A.A. Mongin, B I. Tranmer and H.K. Kimelberg, Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat, J. Neurochem. 76, 1842–1850 (2001).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer Science+Business Media, Inc.

About this paper

Cite this paper

Kimelberg, H.K. (2004). Volume Activated Anion Channel and Astrocytic Cellular Edema in Traumatic Brain Injury and Stroke. In: Lauf, P.K., Adragna, N.C. (eds) Cell Volume and Signaling. Advances in Experimental Medicine and Biology, vol 559. Springer, Boston, MA . https://doi.org/10.1007/0-387-23752-6_15

Download citation

Publish with us

Policies and ethics