Skip to main content

Release of Noradrenaline in the Locus Coeruleus

  • Chapter
Dendritic Neurotransmitter Release

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

7. References

  • Aghajanian, K., Cedarbaum, J. M., and Wang, R. Y., 1977, Evidence for norepinefrine-mediated collateral inhibition of locus coeruleus neurons, Brain Res. 136: 570.

    CAS  Google Scholar 

  • Alreja, M., and Aghajanian, G. K., 1991, Pacemaker activity of locus coeruleus neurons: whole-cell recordings in brain slices show dependence on cAMP and protein kinase A, Brain Res. 556: 339.

    Article  PubMed  CAS  Google Scholar 

  • Alvarez-Maubecin, V., Garcia-Hernandez, F., Williams, J. T., and Van Bockstaele, E. J., 2000, Functional coupling between neurons and glia, J. Neurosci. 20: 4091.

    PubMed  CAS  Google Scholar 

  • Aston-Jones, G., and Bloom, F. E., 1981, Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle, J. Neurosci. 1: 876.

    PubMed  CAS  Google Scholar 

  • Aston-Jones, G., Rajkowski, J., and Cohen, J., 1999, Role of locus coeruleus in attention and behavioral flexibility, Biol. Psychiatry. 46: 1309.

    Article  PubMed  CAS  Google Scholar 

  • Aston-Jones, G., Shipley, M. T., Chouvet, G., Ennis, M., Van Bockstaele, E., Pieribone, V., Shiekhattar, R., Akaoka, H., Drolet, D., and Astier, B., 1991, Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology, Prog. Brain Res. 88: 47.

    PubMed  CAS  Google Scholar 

  • Aston-Jones, G., Shipley, M. T., and Grzanna, R., 1995, The locus coeruleus, A5 and A7 noradrenergic cell groups, in: The Rat Nervous System, G. Paxinos, ed., Academic Press, San Diego, CA, pp. 183–213.

    Google Scholar 

  • Berridge, C. W., and Abercrombie, E. D., 1999, Relationship between locus coeruleus discharge rates and rates of norepinephrine release within neocortex as assessed by in vivo microdialysis, Neuroscience 93: 1263.

    Article  PubMed  CAS  Google Scholar 

  • Berridge, C. W., and Waterhouse, B. D., 2003, The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes, Brain Res. Rev. 42: 33.

    Article  PubMed  Google Scholar 

  • Callado, L. F., and Stamford, J. A., 1999, Alpha2A-but not alpha2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data, Eur. J. Pharmacol. 366: 35.

    Article  PubMed  CAS  Google Scholar 

  • Cintra, L., Diaz-Cintra, S., Kemper, T., and Morgane. P. J., 1982, Nucleus locus coeruleus: a morphometric Golgi study in rats of three age groups, Brain Res. 247: 17.

    Article  PubMed  CAS  Google Scholar 

  • Geffen, L. B., Jessell, T. M., Cuello, A. C., and Iversen, L. L., 1976, Release of dopamine from dendrites in rat substantia nigra, Nature 260: 258.

    Article  PubMed  CAS  Google Scholar 

  • Groves, P. M., and Wilson, C. J., 1980, Monoaminergic presynaptic axons and dendrites in rat locus coeruleus seen in reconstructions of serial sections, J. Comp. Neurol. 193: 853.

    Article  PubMed  CAS  Google Scholar 

  • Ishimatsu, M., and Williams, J. T., 1996, Synchronous activity in locus coeruleus results from dendritic interactions in pericoerulear regions, J. Neurosci. 16: 5196.

    PubMed  CAS  Google Scholar 

  • Ivanov, A., and Aston-Jones, G., 1995, Extranuclear dendrites of locus coeruleus neurons: activation by glutamate and modulation of activity by alpha adrenoceptors, J. Neurophysiol. 74: 2427.

    PubMed  CAS  Google Scholar 

  • Kawahara, Y., Kawahara, H., and Westerink, B. H., 1999, Comparison of effects of hypotension and handling stress on the release of noradrenaline and dopamine in the locus coeruleus and medial prefrontal cortex of the rat, Naunyn Schmiedebergs Arch. Pharmacol. 360: 42.

    Article  PubMed  CAS  Google Scholar 

  • Kawahara, H., Kawahara, Y., and Westerink, B. H., 2000, The role of afferents to the locus coeruleus in the handling stress-induced increase in the release of noradrenaline in the medial prefrontal cortex: a dual-probe microdialysis study in the rat brain, Eur. J. Pharmacol. 387: 279.

    Article  PubMed  CAS  Google Scholar 

  • Kawahara, H., Kawahara, Y., and Westerink, B. H., 2001, The noradrenaline-dopamine interaction in the rat medial prefrontal cortex studied by multi-probe microdialysis, Eur. J. Pharmacol 418: 177.

    Article  PubMed  CAS  Google Scholar 

  • Korf, J., Zieleman, M., and Westerink, B. H., 1976, Dopamine release in substantia nigra? Nature 260: 257.

    Article  PubMed  CAS  Google Scholar 

  • Korf, J., Zieleman, M., and Westerink, B. H., 1977, Metabolism of dopamine in the substantia nigra after antidromic activation, Brain Res. 120: 184.

    Article  PubMed  CAS  Google Scholar 

  • Lambas-Senas, L., Chamba, G., Fety, R., and Renaud, B., 1986, Comparative responses of the central adrenaline-and noradrenaline-containing neurons after reserpine injections, Biochem. Pharmacol. 35:2207.

    Article  PubMed  CAS  Google Scholar 

  • Lee, A., Rosin, D. L., and Van Bockstaele, E. J., 1998, Alpha2A-adrenergic receptors in the rat nucleus locus coeruleus: subcellular localization in catecholaminergic dendrites, astrocytes, and presynaptic axon terminals, Brain Res. 795: 157.

    Article  PubMed  CAS  Google Scholar 

  • Ludwig, M., and Pittman, Q. J., 2003, Talking back: dendritic neurotransmitter release, Trends Neurosci. 26:255.

    Article  PubMed  CAS  Google Scholar 

  • Luppi, P. H., Aston-Jones, G., Akaoka, H., Chouvet, G., and Jouvet, M., 1995, Afferent projections to the rat locus coeruleus demonstrated by retrograde and anterograde tracing with cholera-toxin B subunit and Phaseolus vulgaris leucoagglutinin, Neuroscience 65: 119.

    Article  PubMed  CAS  Google Scholar 

  • Mateo, Y., and Meana, J. J., 1999, Determination of the somatodendritic alpha2-adrenoceptor subtype located in rat locus coeruleus that modulates cortical noradrenaline release in vivo, Eur. J. Pharmacol. 379: 53.

    Article  PubMed  CAS  Google Scholar 

  • Mateo, Y., Pineda, J., and Meana, J. J., 1998, Somatodendritic alpha2-adrenoceptors in the locus coeruleus are involved in the in vivo modulation of cortical noradrenaline release by the antidepressant desipramine, J. Neurochem. 71: 790.

    Article  PubMed  CAS  Google Scholar 

  • Nakamura, S., Kimura, F., and Sakaguchi, T., 1987, Postnatal development of electrical activity in the locus ceruleus, J. Neurophysiol. 58: 510.

    PubMed  CAS  Google Scholar 

  • Nakamura, S., Sakaguchi, T., Kimura, F., and Aoki, F., 1988, The role of alpha 1-adrenoceptor-mediated collateral excitation in the regulation of the electrical activity of locus coeruleus neurons, Neuroscience 27:921.

    Article  PubMed  CAS  Google Scholar 

  • Ordway, G. A., Stockmeier, C. A., Cason, G. W., and Klimek, V., 1997, Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei, J. Neurosci. 17: 1710.

    PubMed  CAS  Google Scholar 

  • Osborne, P. B., Vidovic, M., Chieng, B., Hill, C. E., and Christie M. J., 2002, Expression of mRNA and functional alpha (l)-adrenoceptors that suppress the GIRK conductance in adult rat locus coeruleus neurons, Br. J. Pharmacol. 135: 226.

    Article  PubMed  CAS  Google Scholar 

  • Palkovits, M., Saavedra, J. M., Jacoboqitz, D. M., Kizer, J. S., Zaborszky, L., and Brownstein, M. J., 1977, Serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophan hydroxylase levels, Brain Res. 130: 121.

    Article  PubMed  CAS  Google Scholar 

  • Pudovkina, O. L., Cremers, T. I. F. H., and Westerink, B. H., 2002, The interaction between the locus coeruleus and dorsal raphe nucleus studied with dual probe microdialysis, Eur. J. Pharmacol. 445: 37.

    Article  PubMed  CAS  Google Scholar 

  • Pudovkina, O. L., Kawahara, Y., de Vries, J., and Westerink, B. H., 2001, The release of noradrenaline in the locus coeruleus and prefrontal cortex studied with dual-probe microdialysis, Brain Res. 906: 38.

    Article  PubMed  CAS  Google Scholar 

  • Shimizu, N., and Imamoto, K., 1970, Fine structure of the locus coeruleus in the rat, Arch Histol. Jpn. 31: 229.

    PubMed  CAS  Google Scholar 

  • Shimizu, N., Katoh, Y., Hida, T., and Satoh, K., 1979, The fine structural organization of the locus coeruleus in the rat with reference to noradrenaline contents, Exp. Brain Res. 37: 139.

    Article  PubMed  CAS  Google Scholar 

  • Shipley, M. T., Fu, L., Ennis, M., Liu, W.L., and Aston-Jones, G., 1996, Dendrites of locus coeruleus neurons extend preferentially into two pericoerulear zones, J. Comp. Neurol. 365: 56.

    Article  PubMed  CAS  Google Scholar 

  • Singewald, N., Kaehler, S.T., Philippu, A., 1999, Noradrenaline release in the locus coeruleus of conscious rats is triggered by drugs, stress and blood pressure changes, Neuroreport 10:1583

    Article  PubMed  CAS  Google Scholar 

  • Singewald, N., and Philippu, A., 1993, Catecholamine release in the locus coeruleus is modified by experimentally induced changes in haemodynamics, Naunyn Schmiedebergs Arch. Pharmacol. 347: 21.

    PubMed  CAS  Google Scholar 

  • Singewald, N., and Philippu, A., 1998, Release of neurotransmitters in the locus coeruleus, Prog. Neurobiol. 56:237.

    Article  PubMed  CAS  Google Scholar 

  • Singewald, N., Schneider, C., Pfitscher, A., and Philippu, A., 1994, In vivo release of catecholamines in the locus coeruleus, Naunyn Schmiedebergs Arch. Pharmacol. 350: 339.

    Article  PubMed  CAS  Google Scholar 

  • Svensson, T. H., Bunney, B. S., and Aghajanian, G. K., 1975, Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine, Brain Res. 92: 291.

    Article  PubMed  CAS  Google Scholar 

  • Swanson, L. W., 1976, The locus coeruleus: a cytoarchitectonic, Golgi and immunohistochemical study in the albino rat, Brain Res. 110: 39.

    Article  PubMed  CAS  Google Scholar 

  • Thomas, D. N., Post, R. M., and Pert, A., 1994, Focal and systemic cocaine differentially affect extracellular norepinephrine in the locus coeruleus, frontal cortex and hippocampus of the anaesthetized rat, Brain Res. 645: 135.

    Article  PubMed  CAS  Google Scholar 

  • Van Gaalen, M., Kawahara, H., Kawahara, Y., and Westerink, B. H., 1997, The locus coeruleus noradrenergic system in the rat brain studied by dual-probe microdialysis, Brain Res. 763: 56.

    Article  PubMed  Google Scholar 

  • Van Veldhuizen, M. J., Feenstra, M. G., Heinsbroek, R. P., and Boer, G. J., 1993, In vivo microdialysis of noradrenaline overflow: effects of alpha-adrenoceptor agonists and antagonists measured by cumulative concentration-response curves, Br. J. Pharmacol. 109: 655.

    PubMed  Google Scholar 

  • Williams, J. T., Bobker, D. H., and Harris, G. C., 1991, Synaptic potentials in locus coeruleus neurons in brain slices, Prog. Brain Res. 88: 167.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Science+Business Media Inc.

About this chapter

Cite this chapter

Pudovkina, O.L., Westerink, B.H.C. (2005). Release of Noradrenaline in the Locus Coeruleus. In: Ludwig, M. (eds) Dendritic Neurotransmitter Release. Springer, Boston, MA. https://doi.org/10.1007/0-387-23696-1_10

Download citation

Publish with us

Policies and ethics