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Neuroendocrine Outcomes of Sleep Deprivation in Humans and Animals

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Neuroendocrine Correlates of Sleep/Wakefulness

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Abstract

Hormones can modulate and be modulated by sleep. This close relationship has been recognised for many decades. Sleep deprivation is an adverse condition that can alter the functioning of the neuroendocrine system, inasmuch as concentrations of hormones involved in anabolic processes, such as growth hormone (GH) are reduced, whilst levels of hormones involved in anabolic processes, such as glucocorticoids (GC) are increased. Therefore, prolonged periods of sleep deprivation, either internally or externally imposed, may lead to a wear and tear phenomenon, much similar to prolonged stressful conditions. In human beings, the vicious circle composed by sleep deprivation, stress and obesity has been claimed to be a major contributor to type II diabetes, cardiovascular diseases and ultimately, death

Abbreviations used in this chapter: ACTH: adrenocorticotropic hormone; ADR: adrenaline; Arc. N.: arcuate nucleus; AVP: arginin vasopressin; CRH: corticotropin-releasing factor; CSF: cerebrospinal fluid; GC: glucocorticoid; GH: growth hormone; GHRH: GH-releasing hormone; HPA: hypothalamus-pituitary-adrenal; LHA: lateral hypothalamic area; MMPM: modified multiple platform method; mRNA: messenger RNA; OT: oxytocin; PVN: paraventricular nucleus; REM: rapid eye movements; TSH: thyrotropin-stimulating hormone

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  1. Paulo Escola Paulista de Medicina, Department of Psychobiology, Universidade Federal de São, Brazil

    Deborah Suchecki & Sergio Tufik

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  1. Deborah Suchecki
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  1. Department of Physiology Faculty of Medicine, University of Buenos Aires, Argentina, Buenos Aires, 1121

    Daniel P. Cardinali

  2. SUNY Downstate Medical Center, Brooklyn, 11203, New York, USA

    S. R. Pandi-Perumal

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Suchecki, D., Tufik, S. (2006). Neuroendocrine Outcomes of Sleep Deprivation in Humans and Animals. In: Cardinali, D.P., Pandi-Perumal, S.R. (eds) Neuroendocrine Correlates of Sleep/Wakefulness. Springer, Boston, MA. https://doi.org/10.1007/0-387-23692-9_9

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