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Sleep-Disordered Breathing and Hormones

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Neuroendocrine Correlates of Sleep/Wakefulness

Abstract

Falling asleep removes postural muscle tone, voluntary respiratory control and the wakefulness stimulus for breathing. These changes predispose to respiratory abnormalities during sleep, including periodic breathing, repetitive episodes of obstructive, mixed or central apnea or hypopnea, or prolonged episodes of partial upper airway obstruction with increased respiratory resistance. In short term, the performance of the respiratory muscles is readily controlled through neural mechanisms, which continuously monitor the metabolic needs of the body by reading the output of chemoreceptors and adjusting alveolar ventilation accordingly. Acute failure of the respiratory control during sleep rapidly results in arousal and activation of the sympathetic division of the autonomic nervous system with increased catecholamine secretion.

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Author information

Authors and Affiliations

  1. Department of Pulmonary Diseases, Turku University Central Hospital, University of Turku, Turku, Finland

    Tarja Saaresranta

  2. Department of Pulmonary Diseases, Tampere University Hospital and Sleep Research Unit, University of Turku, Tampere, Finland

    Olli Polo

Authors
  1. Tarja Saaresranta
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  2. Olli Polo
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Editor information

Editors and Affiliations

  1. Department of Physiology Faculty of Medicine, University of Buenos Aires, Argentina, Buenos Aires, 1121

    Daniel P. Cardinali

  2. SUNY Downstate Medical Center, Brooklyn, 11203, New York, USA

    S. R. Pandi-Perumal

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Saaresranta, T., Polo, O. (2006). Sleep-Disordered Breathing and Hormones. In: Cardinali, D.P., Pandi-Perumal, S.R. (eds) Neuroendocrine Correlates of Sleep/Wakefulness. Springer, Boston, MA. https://doi.org/10.1007/0-387-23692-9_23

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