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Some Aspects of DNA Condensation Observed by Fluorescence Correlation Spectroscopy

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Reviews in Fluorescence 2005

Part of the book series: Reviews in Fluorescence ((RFLU,volume 2005))

Abstract

Conformational changes of macromolecules are a crucial issue that needs to be comprehended before the processes occurring in living systems are understood. They decide about the adaptability of protein tertiary and quaternary structures, which in turn determines their functions and how they will interact with other elements of the system. Protein folding is one of the leading research areas in the modern biology (Arnold et al., 2001; Ellis and Hartl, 1999; Grantcharova et al., 2001). Similar problems are encountered when the conformation of other macromolecules need to be considered, i.e. supramolecular aggregates. Phenomena related to the structure and dynamics of such aggregates form the basis for the function of larger structures, starting from the biological membrane and ending on the processing of genetic information. Despite the fact that the properties of a number a single molecular identities are being successfully tackled, their behavior in large functional ensembles is barely been touched (Lenart and Ellenberg, 2003; Matouschek, 2003; Nakai, 2001; Nelson and Yeaman, 2001; Parak, 2003)

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Authors and Affiliations

  1. J. Heyrovský Institute, Academy of Sciences of Czech Republic and Center for Complex Molecular Systems and Biomolecules, Dolejškova 3, Cz-18223, Prague 8, Czech Republic

    Teresa Kral, Aleš Benda & Martin Hof

  2. Department of Physics and Biophysics, Agricultural University, Norwida 25, 50-375, Wroclaw, Poland

    Teresa Kral

  3. Institute of Physics, Wroclaw University of Technology, Wyb. Wyspiańskiego 27, 50-370, Wrocław, Poland

    Marek Langner

  4. Academic Centre for Biotechnology of Lipids Aggregates, Przybyszewskiego 63/67, 51-148, Wrocław, Poland

    Marek Langner

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  1. Teresa Kral
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  2. Aleš Benda
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  3. Martin Hof
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  4. Marek Langner
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Editors and Affiliations

  1. Institute of Fluorescence and Center for Fluorescence Spectroscopy, University of Maryland Biotechnology Institute, Baltimore, Maryland

    Chris D. Geddes

  2. Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Baltimore, Maryland

    Joseph R. Lakowicz

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Kral, T., Benda, A., Hof, M., Langner, M. (2005). Some Aspects of DNA Condensation Observed by Fluorescence Correlation Spectroscopy. In: Geddes, C.D., Lakowicz, J.R. (eds) Reviews in Fluorescence 2005. Reviews in Fluorescence, vol 2005. Springer, Boston, MA. https://doi.org/10.1007/0-387-23690-2_5

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