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9. Conclusion

Ricin is a potent and easy to extract plant toxin. Its characteristics make it a potentially dangerous biological weapon. We understand now, better than ever, the pathogenesis of ricin poisoning. But treatment of ricin poisoning is still mainly supportive. More research is needed to develop specific and effective modalities of treatment.

The threat of bioterrorism is no longer as remote as it was in the past. The medical community should be familiar with the clinical presentation and treatment of ricin poisoning. Knowledge will allow better recognition and response to an attack.

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References

  • Alibek, K. (1999). Biohazard. New York, Random House, Inc.

    Google Scholar 

  • CDC. (2000). Biological and chemical terrorism: strategic plan for preparedness and response recommendations of the CDC Strategic Planning Workgroup. MMWR 49(RR-4):1–14.

    Google Scholar 

  • Centers for Disease Control and Prevention. (2003). Laboratory testing for ricin in environmental samples—fact sheet. Available at: http://www.bt.cdc.gov/agent/ricin/labtesting.asp.

    Google Scholar 

  • Challoner, K.R., and McCarron, M.M. (1990). Castor bean intoxication. Ann. Emerg. Med. 19:1177–1183.

    Article  PubMed  CAS  Google Scholar 

  • Christopher, G.W., Cieslak, T.J., Palvin, J.A., and Eitzen, E.M. (1997). Biological warfare. A historical perspective. J.A.M.A. 278:412–417.

    PubMed  CAS  Google Scholar 

  • Crompton, R., and Gall, D. (1980). Georgi Markov—death in a pellet. Medico Legal J. 48(2):51–62.

    CAS  Google Scholar 

  • Eitzen, E.M., and Takafuji, E.T. (1997). Historical overview of biological warfare. In: Sidell, F.R., Takafuji, E.T., and Franz, D.R. (eds.), Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare. TMM Publications, Washington, D.C.

    Google Scholar 

  • Ellenhorn, M.J. (1997). Plants — mycotoxins — mushrooms. In: Ellenhorn’s Medical Toxicology: Diagnosis and Treatment of Human Poisoning. Baltimore, Williams & Wilkins, pp. 1847–1849.

    Google Scholar 

  • Fodstad, O., Kvalheim, G., Godal, A., Lotsberg, J., Aamdal, S., Host, H., and Pihl, A. (1984). Phase I study of plant protein ricin. Cancer Res. 44:862–865.

    PubMed  CAS  Google Scholar 

  • Franz, D.R., and Jaax, N.K. (1997). Ricin toxin. In: Sidell, F.R., Takafuji, E.T., and Franz, D.R. (eds.), Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare. TMM Publications, Washington, D.C.

    Google Scholar 

  • Frigerio, L., and Roberts, L.M. (1998). The enemy within: ricin and plant cells. J. Exp. Botany 49(326):1473–1480.

    Article  CAS  Google Scholar 

  • Hampton, T. (2004). Ricin vaccine developed. JAMA 292:1419-a.

    Google Scholar 

  • Hostetler, M.A. (2003). Toxicity, plants — castor bean and jequirity bean. Available at: http://www.emedicine.com/ped/topic331.htm.

    Google Scholar 

  • Kaku, H. (1998). Ricin related protein family. Available at: http://www.glycoforum.gr.jp/science/word/lectin/LEA08E.html.

    Google Scholar 

  • Kende, M., Yan, C., Hewetson, J., Frick, M.A., Rill, W.L., and Tammariello, R. (2002). Oral immunization of mice with ricin toxoid vaccine encapsulated in polymeric microspheres against aerosol challenge. Vaccine 20(11–12):1681–1691.

    Article  PubMed  CAS  Google Scholar 

  • Koppel, A., MacVicar, S., Schuster, H., and Moniquet, C. (2003). Deadly ricin at Paris rail station. Available at: http://www.cnn.com/2003/WORLD/europe/03/20/france.ricin/index.html.

    Google Scholar 

  • Kortepeter, M.G., Christopher, G., Cieslak, T., Culpepper, R., Darling, R., Palvin, J., Rowe, J., McKee, K., and Eitzen, E. (2001). USAMRIID’s Medical Management of Biological Casualties Handbook, 4th ed. U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, pp. 130–137.

    Google Scholar 

  • Kortepeter, M.G., and Parker, G.W. (1999). Potential biological weapons threats. Emerg. Infect. Dis. 5:523–527.

    Article  PubMed  CAS  Google Scholar 

  • Kreitman, R.J. (1999). Immunotoxins in cancer therapy. Curr. Opin. Immunol. 11:570–578.

    Article  PubMed  CAS  Google Scholar 

  • Kreitman, R.J. (2001). Toxin-labeled monoclonal antibodies. Curr. Pharm. Biotechnol. 2:313–325.

    Article  PubMed  CAS  Google Scholar 

  • Lord, J.M., Roberts, L.M., and Robertus J.D. (1994). Ricin: structure, mode of action, and some current applications. FASEB J. 8:201–208.

    PubMed  CAS  Google Scholar 

  • Maman, M., Sagi, R., Moseri, R., and Yehezkelli, Y. (2003). Ricin—a potent plant toxin. In: Shoenfeld, Y., and Shemer, J. (eds.), Terror and Medicine. Pabst Science Publishers, Berlin.

    Google Scholar 

  • Mayor, S. (2003). UK doctors warned after a ricin poison was found in police raid. Br. Med. J. 326:126.

    Google Scholar 

  • Mirarchi, F.L., and Allswede, M. (2003). CBRNE — ricin. Available at: http://www.emedicine.com/emerg/topic889.htm.

    Google Scholar 

  • Oeltmann, T.N., and Frankel, A.E. (1991). Advances in immunotoxins. FASEB J. 5(10):2334–2337.

    PubMed  CAS  Google Scholar 

  • Old Testament. (1982). Jonah 4:6–9. Copyright by Y. Orestein, “Yavne” Publishing House, Ltd., Tel-Aviv.

    Google Scholar 

  • Olsnes, S., and Kozlov, J.V. (2001). Ricin. Toxicon 39:1723–1728.

    Article  PubMed  CAS  Google Scholar 

  • Olsnes, S., and Pihl, A. (1976). Abrin, ricin and their associated agglutinins. In Cuatrecasas, P. (eds.), Receptors and Recognition. Series B. The Specificity and Action of Animal, Bacterial and Plant Toxins. Chapman and Hall, London, pp. 129–173.

    Google Scholar 

  • Rauber, A., and Heard, J. (1985). Castor bean toxicity re-examined: a new prospective. Vet. Hum. Toxicol. 27:498–502.

    PubMed  CAS  Google Scholar 

  • Sandvig, K., and Van Deurs, B. (2000). Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives. EMBO J. 19:5943–5950.

    Article  PubMed  CAS  Google Scholar 

  • Sandvig, K., and Van Deurs, B. (2002). Transport of protein toxins into cells: pathways used by ricin, cholera toxin and shiga toxin. FEBS Lett. 529(1):49–53.

    Article  PubMed  CAS  Google Scholar 

  • Shyu, H.F., Chaio, D.J., Liu, H.W., and Tang, S.S. (2002). Monoclonal antibody-based enzyme immunoassay for detection ricin. Hybrid Hybridomics 21:69–73.

    Article  PubMed  CAS  Google Scholar 

  • Smallshaw, J.E., Firan, A., Fulmer, J.R., Ruback, S.L, Ghetie, V., and Vitetta, E.S. (2002). A novel recombinant vaccine which protects mice against ricin intoxication. Vaccine 20:3422–3427.

    Article  PubMed  CAS  Google Scholar 

  • Wedin, G.P., Neal, J.S., Everson, G.W., and Krenzelok, E.P. (1986). Castor bean poisoning. Am. J. Emerg. Med. 4(3):259–261.

    Article  PubMed  CAS  Google Scholar 

  • Weissmann-Brenner, A., Brenner, B., Kats, L., and Hourvitz, A. (2002). Ricin — from a Bulgarian umbrella to an optional treatment of cancer. Harefuah 141:153–156. [Hebrew].

    PubMed  Google Scholar 

  • Yan, C., Rill, W.L., Malli, R., Hewetson, J., Naseem, H., Tammariello, R., and Kende, M. (1996). Intranasal stimulation of long lasting immunity against aerosol ricin challenge with ricin toxoid vaccine encapsulated in polymer microspheres. Vaccine 14:1031–1038.

    Article  PubMed  CAS  Google Scholar 

  • Zilinskas, R.A. (1997). Iraq’s biological weapons: the past as future? J.A.M.A. 278:418–424.

    Article  PubMed  CAS  Google Scholar 

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Maman, M., Yehezkelli, Y. (2005). Ricin: A Possible, Noninfectious Biological Weapon. In: Fong, I.W., Alibek, K. (eds) Bioterrorism and Infectious Agents: A New Dilemma for the 21st Century. Emerging Infectious Diseases of the 21st Century. Springer, Boston, MA. https://doi.org/10.1007/0-387-23685-6_8

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  • DOI: https://doi.org/10.1007/0-387-23685-6_8

  • Publisher Name: Springer, Boston, MA

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