Anthrax: A Disease and a Weapon

  • Kenneth Alibek
  • Catherine Lobanova
  • Serguei Popov
Part of the Emerging Infectious Diseases of the 21st Century book series (EIDC)


Bacillus Anthracis Biological Weapon Lethal Toxin Anthrax Toxin Edema Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Abramova, A.A., and Grinberg, L.M. (1993). [Pathology of anthrax sepsis according to materials of the infectious outbreak in 1979 in Sverdlovsk (microscopic change s)] Arkh. Patol. 55:18–23 (in Russian).PubMedGoogle Scholar
  2. Abramova, F.A., Grinberg, L.M., Yampolskaya, O.V., and Walker, D.H. (1993). Pathology of inhalational anthrax in 42 cases from the Sverdlovsk outbreak of 1979. Proc. Natl. Acad. Sci. U.S.A. 90:2291–2294.PubMedGoogle Scholar
  3. ABS, a Subsidiary of Analex. (2004). Report to the Department of State, August.Google Scholar
  4. Albrink, W., Brooks, S., Biron, R., and Kopel, M. (1960). Human inhalation anthrax: a report of three fatal cases. Am. J. Pathol. 36:457–468.PubMedGoogle Scholar
  5. Albrink, W.S., and Goodlow, R.J. (1959). Experimental inhalation anthrax in chimpanzees. Am. J. Pathol. 35:1055–1065.PubMedGoogle Scholar
  6. Alibek, K. (1999). Biohazard: The Chilling True Story of the Largest Covert Biological Weapons Program in the World — Told from Inside by the Man Who Ran It. Random House, New York, p. 74.Google Scholar
  7. Barakat, L.A., Quentzel, H.L., Jernigan, J.A., Kirschke, D.L., Griffith, K., Spear, S.M., Kelley, K., Barden, D., Mayo, D., Stephens, D.S., Popovic, T., Marston, C., Zaki, S.R., Guarner, J., Shieh, W.J., Carver, H.W. 2nd, Meyer, R.F., Swerdlow, D.L., Mast, E.E., and Hadler, J.L. [Anthrax Bioterrorism Investigation Team]. (2002). Fatal inhalational anthrax in a 94-year-old Connecticut woman. J.A.M.A., 287(7):863–868.PubMedGoogle Scholar
  8. Barnaby, W. (2000). The Plague Makers: The Secret World of Biological Weapons. Continuum, New York, 123.Google Scholar
  9. Belluck, P. (2001). Anthrax Outbreak of’ 57 Felled a Mill but Yielded Answers. New York Times, October 27, 2001.Google Scholar
  10. Bonventre, P.F., and Eckert, N.J. (1963). The biologic activities of Bacillus anthracis and Bacillus cereus culture filtrates. Am. J. Pathol. 43:201–211.PubMedGoogle Scholar
  11. Bonventre, P.F., Sueoka, W., True, C.W., Klein, F., and Lincoln, R. (1967). Attempts to implicate the central nervous system as a primary site of action for Bacillus anthracis lethal toxin. Fed. Proc. 26:1549–1553.PubMedGoogle Scholar
  12. Brachman, P., and Pagano, J. (1961). Two cases of fatal inhalation anthrax, one associated with sarcoidosis. N. Engl. J. Med. 265:203–208.CrossRefGoogle Scholar
  13. Brachman, P.S. (1980). Inhalation anthrax. Ann N.Y. Acad. Sci. 353:83–93.PubMedGoogle Scholar
  14. Brook, I. (2002). The prophylaxis and treatment of anthrax. Int. J. Antimicrob. Agents 20(5):320–325 [review].PubMedCrossRefGoogle Scholar
  15. Brooksher, W., and Briggs, J. (1920). Pulmonary anthrax: report of a case. J.A.M.A. 74:323–324.Google Scholar
  16. Bush, L.M., Abrams, B.H., Beall, A., and Johnson, C.C. (2001). Index case of fatal inhalational anthrax due to bioterrorism in the United States. N. Engl. J. Med. 345:1607–1610.PubMedCrossRefGoogle Scholar
  17. Carucci, J.A., McGovern, T.W., Norton, S.A., Daniel, C.R., Elewski, B.E., Fallon-Friedlander, S., Lushniak, B.D., Taylor, J.S., Warschaw, K., and Wheeland, R.G. (2002). Cutaneous anthrax management algorithm. J. Am. Acad. Dermatol. 47(5):766–769.PubMedCrossRefGoogle Scholar
  18. Carus, W.S. (2001). Bioterrorism and Biocrimes: The Illicit Use of Biological Agents Since 1900. Washington, D.C.: National Defense University Center for Counterproliferation Research, pp. 108–109.Google Scholar
  19. CDC Emergency Preparedness and Response Website. (2001). Anthrax Q & A. Google Scholar
  20. CDC Treatment Protocols for Cases of Inhalational and Cutaneous Anthrax Associated with Bioterrorist Attack Website. (2001). Anthrax Q & A. Google Scholar
  21. Chandramukhi, A., Shankar, P., Rao, T., Sundararajan, S., and Swamy, H.S. (1987). Acute leptomeningitis due to Bacillus anthracis. Trop. Geol. Med. 35:79–82.Google Scholar
  22. (2001). Anthrax through the ages. Google Scholar
  23. Cole, S.T., Eiglmeier, K., Parkhill, J., James, K.D., Thomson, N.R., Wheeler, P.R., Honore, N., Garnier, T., Churcher, C., Harris, D., Mungall, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R.M., Devlin, K., Duthoy, S., Feltwell, T., Fraser, A., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Lacroix, C., Maclean, J., Moule, S., Murphy, L., Oliver, K., Quail, M.A., Rajandream, M.A., Rutherford, K.M., Rutter, S., Seeger, K., Simon, S., Simmonds, M., Skelton, J., Squares, R., Squares, S., Stevens, K., Taylor, K., Whitehead, S., Woodward, J.R., and Barrell, B.G. (2001). Massive gene decay in the leprosy bacillus. Nature 409:1007–1011.PubMedCrossRefGoogle Scholar
  24. Committee to Assess the Safety and Efficacy of the Anthrax Vaccine, Medical Follow-Up Agency. (2002). The Anthrax Vaccine: Is It Safe? Does It Work? Institute of Medicine, National Academy Press, Washington, D.C.,$file/Anthrax-8-pager1FINAL.pdf. Google Scholar
  25. Cowdery, J. (1947). Primary pulmonary anthrax with septicemia. Arch. Pathol. 43:396–399.Google Scholar
  26. Cranmer, H., and Martinez, M. (2003). CBRNE — anthrax infection. Google Scholar
  27. Dalldorf, F.G., and Beall, F.A. (1967). Capillary thrombosis as a cause of death in experimental anthrax. Arch. Pathol. 83:154–161.PubMedGoogle Scholar
  28. Dixon, T.C., Fadl, A.A., Koehler, T.M., Swanson, J.A., and Hanna, P.C. (2000). Early Bacillus anthracismacrophage interactions: intracellular survival survival and escape. Cell Microbiol. 2:453–463.PubMedCrossRefGoogle Scholar
  29. Doganay, M., Almac, A., and Hanagasi, R. (1986). Primary throat anthrax. Scand. J. Infect. Dis. 18:415–419.PubMedGoogle Scholar
  30. Drake, D.J., and Blair, A.W. (1971). Meningitic anthrax. Cent. Afr. J. Med. 17:97–98.PubMedGoogle Scholar
  31. Dutz, W., and Kohout, E. (1971). Anthrax. Pathol. Annu. 6:209–248.PubMedGoogle Scholar
  32. Enticknap, J.B., Galbraith, N.S., Tomlinson, A.J.H., and Elias-Jones, T.F. (1968). Pulmonary anthrax caused by contaminated sacks. Br. J. Industr. Med. 25:72–74.Google Scholar
  33. Eremin, S.A., Nikiforov, A.K., Kostiukova, T.A., and Mikshis, N.I. (1999). The capacity of the causative agent of anthrax to reduce methylene blue. Zh. Mikrobiol. Epidemiol. Immunobiol. 4:91–92 (in Russian).PubMedGoogle Scholar
  34. Erwin, J.L., DaSilva, L.M., Bavari, S., Little, S.F., Friedlander, A.M., and Chanh, T.C. (2001). Macrophage-derived cell lines do not express proinflammatory cytokines after exposure to Bacillus anthracis lethal toxin. Infect. Immun. 69:1175–1177.PubMedCrossRefGoogle Scholar
  35. Fellows, P., Linscott, M., Ivins, B., et al. (2001). Efficacy of a human anthrax vaccine in guinea pigs, rabbits, and rhesus macaques against challenge by Bacillus anthracis isolates of diverse geographical origin. Vaccine 19:3241–3247.PubMedCrossRefGoogle Scholar
  36. Fouet, A., Sirard, J.C., and Mock, M. (1994). Bacillus anthracis pXO1 virulence plasmid encodes a type 1 DNA topoisomerase. Mol. Microbiol. 11:471–479.PubMedGoogle Scholar
  37. Friedlander, A.M. (1986). Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. J. Biol. Chem. 261:7123–7126.PubMedGoogle Scholar
  38. Friedlander, A.M., Welkos, S.L., Pitt, M.L.M., Ezzell, J.W., Worsham, P.L., Rose, K.J., Ivins, B.E., Lowe, J.R., Howe, G.B., Mikesell, P., and Lawrence, W.B. (1993). Postexposure prophylaxis against experimental inhalation anthrax. J. Infect. Dis. 167:1239–1243.PubMedGoogle Scholar
  39. Fukao, T. (2004). Immune system paralysis by anthrax lethal toxin: the roles of innate and adaptive immunity. Lancet Infect. Dis. 4:166–170 [review].PubMedCrossRefGoogle Scholar
  40. Gold, H. (1955). Anthrax: a report of one hundred seventeen cases. AMA Arch. Intern. Med. 96:387–396.PubMedGoogle Scholar
  41. Goodman, J.W., and Nitecki, D.E. (1967). Studies on the relation of a prior immune response to immunogenicity. Immunology 13:577–583.PubMedGoogle Scholar
  42. Gordon, V.M., Klimpel, K.R., Arora, N., Henderson, M.A., and Leppla, S.H. (1995). Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases. Infect. Immun. 63:82–87.PubMedGoogle Scholar
  43. Greenwood, D., Slack, R., and Peutherer, J. (1997). Medical Microbiology. A Guide to Microbial Infections: Pathogenesis, Immunity, Laboratory Diagnosis and Control. Churchill Livingstone, New York.Google Scholar
  44. Grinberg, L.M., Abramova, F.A., Yampolskaya, O.V., Walker, D.H., and Smith, J.H. (2001). Quantitative pathology of inhalational anthrax I: quantitative microscopic findings. Mod. Pathol. 14:482–495.PubMedCrossRefGoogle Scholar
  45. Guidi-Rontani, C., Levy, M., Ohayon, H., and Mock, M. (2001). Fate of germinated Bacillus anthracis spores in primary murine macrophages. Mol. Microbiol. 42:931–938 [erratum in Mol. Microbiol. 2002;44:297].PubMedCrossRefGoogle Scholar
  46. Guidi-Rontani, C., Pereira, Y., Ruffie, S., Sirard, J.C., Weber-Levy, M., and Mock, M. (1999). Identification and characterization of a germination operon on the virulence plasmid pXO1 of Bacillus anthracis. Mol. Microbiol. 33:407–414.PubMedCrossRefGoogle Scholar
  47. Guidi-Rontani C., Weber-Levy, M., Labruyère, E., and Mock, M. (1999). Germination of Bacillus anthracis spores within alveolar macrophages. Mol. Microbiol. 31:9–17.PubMedCrossRefGoogle Scholar
  48. Haight, T.H. (1952). Anthrax meningitis: review of literature and report of two cases with autopsies. Am. J. Med. Sci. 224:57–69.PubMedGoogle Scholar
  49. Hail, A.S., Rossi, C.A., Ludwig, G.V., Ivins, B.E., Tammariello, R.F., and Henchal, E.A. (1999). Comparison of non-invasive sampling sites for early detection of Bacillus anthracis spores from rhesus monkeys after aerosol exposure. Mil. Med. 164:833–837.PubMedGoogle Scholar
  50. Hanna, P.C., Kruskal, B.A., Ezekowitz, R.A., Bloom, B.R., and Collier, R.J. (1994). Role of macrophage oxidative burst in the action of anthrax lethal toxin. Mol. Med. 1:7–18.PubMedGoogle Scholar
  51. Hansen, H.J., Norberg, B.K., and Schmiterloew, C.G. (1961). Pathophysiological studies on anthrax. Acta Pathol. Microbiol. Scand. 51(Suppl 144):307–308.PubMedGoogle Scholar
  52. Heidelberg, J.F., Eisen, J.A., Nelson, W.C., Clayton, R.A., Gwinn, M.L., Dodson, R.J., Haft, D.H., Hickey, E.K., Peterson, J.D., Umayam, L., Gill, S.R., Nelson, K.E., Read, T.D., Tettelin, H., Richardson, D., Ermolaeva, M.D., Vamathevan, J., Bass, S., Qin, H., Dragoi, I., Sellers, P., McDonald, L., Utterback, T., Fleishmann, R.D., Nierman, W.C., and White, O. (2000). DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature 406:477–483.PubMedCrossRefGoogle Scholar
  53. Inglesby, T.V., O’Toole, T., Henderson, D.A., Bartlett, J.G., Ascher, M.S., Eitzen, E., Friedlander, A.M., Gerberding, J., Hauer, J., Hughes, J., McDade, J., Osterholm, M.T., Parker, G., Perl, T.M., Russell, T.K., and Tonat, K. (2002). Anthrax as a biological weapon, 2002: updated recommendations for management. J.A.M.A. 287:2236–2252 [review; erratum in J.A.M.A. 2002;288:1849].PubMedCrossRefGoogle Scholar
  54. Ivins, B.E., Fellows, P., and Pitt, M.L., et al. (1996). Efficacy of standard human anthrax vaccine against Bacillus anthracis aerosol spore challenge in rhesus monkeys. Salisbury Med. Bull. 87:125–126.Google Scholar
  55. Jamie, W.E. (2002). Anthrax: diagnosis, treatment, prevention. Primary Care Update for OB/GYNs 9:117–121.CrossRefGoogle Scholar
  56. Jernigan, D.B., Raghunathan, P.L., Bell, B.P., Brechner, R., Bresnitz, E.A., Butler, J.C., Cetron, M., Cohen, M., Doyle, T., Fischer, M., Greene, C., Griffith, K.S., Guarner, J., Hadler, J.L., Hayslett, J.A., Meyer, R., Petersen, L.R., Phillips, M., Pinner, R., Popovic, T., Quinn, C.P., Peefhuis, J., Reissman, D., Rosenstein, N., Schuchat, A., Shieh, W.J., Siegal, L., Swerdlow, D.L., Tenover, F.C., Traegar, M., Ward, J.W., Weisfuse, I., Wiersma, S., Yeskey, K., Zaki, S., Ashford, D.A., Perkins, B.A., Ostroff, S., Hughes, J., Fleming, D., Koplan, J.P., Gerberding, and the National Anthrax Investigation Team. (2002). Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findings. Emerg. Infect. Dis. 8:1019–1028.PubMedGoogle Scholar
  57. Jernigan, J.A., Stephens, D.S., Ashford, D.A., Omenaca, C., Topiel, M.S., Galbraith, M., Tapper, M., Fisk, T.L., Zaki, S., Popovic, T., Meyer, R.F., Quinn, C.P., Harper, S.A., Fridkin, S.K., Sejvar, J.J., Shepard, C.W., McConnell, M., Guarner, J., Shieh, W.J., Malecki, J.M., Gerberding, J.L., Hughes, J.M., Perkins, B.A., and members of the Anthrax Bioterrorism Investigation Team. (2001). Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States. Emerg. Infect. Dis. 7:933–944.PubMedCrossRefGoogle Scholar
  58. Keim, P., Smith, K.L., Keys, C., Takahashi, H., Kurata, T., and Kaufmann, A. (2001). Molecular investigation of the Aum Shinrikyo anthrax release in Kameido, Japan. J. Clin. Microbiol. 39(12):4566–4567.PubMedCrossRefGoogle Scholar
  59. Klein, F., Hodges, D.R., Mahlandt, B.G., Jones, W.I., Haines, B.W., and Lincoln, R.E. (1962). Anthrax toxin: causative agent in the death of rhesus monkeys. Science. 138:1331–1333.PubMedGoogle Scholar
  60. Klein, F., Walker, J.S., Fitzpatrick, D.F., Lincoln, R.E., Mahlandt, B.G., Jones, W.I. Jr, Dobbs J.P., and Hendrix, K.J. (1966). Pathophysiology of anthrax. J. Infect. Dis. 116:123–138.PubMedGoogle Scholar
  61. Klichko, V.I., Miller, J., Wu, A., Popov, S.G., and Alibek, K. (2003). Anaerobic induction of Bacillus anthracis hemolytic activity. Biochem. Biophys. Res. Commun. 303:855–862.PubMedCrossRefGoogle Scholar
  62. Knights, E.M. (0000). Anthrax. History Magazine. Accessed online at: Google Scholar
  63. Koshi, G.M., Lalitha, D.J., Chacko, A., and Pulimood, B. (1981). Anthrax meningitis, a rare clinical entity. J Assoc. Phys. Ind. 29:59–62.Google Scholar
  64. Kozel, T.R., Murphy, W.J., Brandt, S., Blazar, B.R., Lovchik, J.A., Thorkildson, P., Percival, A., and Lyons, C.R. (2004). mAbs to Bacillus anthracis capsular antigen for immunoprotection in anthrax and detection of antigenemia. Proc. Natl. Acad. Sci. U.S.A. 101:5042–5047PubMedCrossRefGoogle Scholar
  65. Krauss, F. (1943). Anthrax appearing primarily in the nose. Arch. Otolaryngol. 37:238–241.Google Scholar
  66. LaForce, F.M., Bumford, F.H., Feeley, J.C., Stokes, S.L., and Snow, D.B. (1969). Epidemiologic study of a fatal case of inhalation anthrax. Arch. Environ. Health. 18:798–805.PubMedGoogle Scholar
  67. Lindberg, A.A. (1999). Polyosides (encapsulated bacteria). C.R. Acad. Sci. 322:925–932.Google Scholar
  68. Lindeque, P.M., and Turnbull, P.C. (1994). Ecology and epidemiology of anthrax in the Etosha National Park, Namibia. Onderstepoort J. Vet. Res. 61:71–83.PubMedGoogle Scholar
  69. Little, S.F., and Ivins, B.E. (1999). Molecular pathogenesis of Bacillus anthracis infection. Microb. Infect. 2:131–139.CrossRefGoogle Scholar
  70. Litusov, N.V., Vasilyev, N.T., Vasilyev, P.G., and Burgasov, P.N. (2002). Pathomorphology of anthrax. Meditsina.Google Scholar
  71. Liu, S., Schubert, R.L., Bugge, T.H., and Leppla, S.H. (2003). Anthrax toxin: structures, functions and tumour targeting. Expert Opin. Biol. Ther. 3:843–853 [review].PubMedCrossRefGoogle Scholar
  72. Macher, A. (2002). An industry-related outbreak of human anthrax, Massachusetts, 1868. Emerg. Infect. Dis. 8:1182.PubMedGoogle Scholar
  73. Makino, S.I., Uchida, I., Terakado, N., Sasakawa, C., and Yoshikawa, M. (1989). Molecular characterization and protein analysis of the cap region, which is essential for encapsulation in Bacillus anthracis. J. Bacteriol. 171:722–730.PubMedGoogle Scholar
  74. Mangold, T., and Goldberg, J. (1999). Plague Wars: The Terrifying Reality of Biological Warfare. St. Martins Griffin, New York, pp. 19–24.Google Scholar
  75. Mesnage, S., Tosi-Couture, E., Gounon, P., Mock, M., and Fouet, A. (1998). The capsule and S-layer: two independent and yet compatible macromolecular structures in Bacillus anthracis. J. Bacteriol. 180:52–58.PubMedGoogle Scholar
  76. Mikesell, P., Ivins, B.E., Ristroph, J.D., Vodkin, M.H., Dreier, T.M., and Leppla, S.H. (1983). Plasmids, Pasteur, and Anthrax. ASM News 49:320–322.Google Scholar
  77. Milne, J.C., and Collier, R.J. (1993). pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen. Mol. Microbiol. 10:647–653.PubMedGoogle Scholar
  78. Milne, J.C., Furlong, D., Hanna, P.C., Wall, J.S., and Collier, R.J. (1994). Anthrax protective antigen forms oligomers during intoxication of mammalian cells. J. Biol. Chem. 269:20607–20612.PubMedGoogle Scholar
  79. Moayeri, M., Haines, D., Young, H.A., and Leppla, S.H. (2003). Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice. J. Clin. Invest. 112:670–682.PubMedCrossRefGoogle Scholar
  80. Mock, M., and Mignot, T. (2003). Anthrax toxins and the host: a story of intimacy. Cell Microbiol. 5:15–23 [review].PubMedCrossRefGoogle Scholar
  81. Mogridge, J., Cunningham, K., and Collier, R.J. (2002). Stoichiometry of anthrax toxin complexes. Biochemistry 41:1079–1082.PubMedCrossRefGoogle Scholar
  82. Nobel Lectures, Physiology or Medicine 1901–1921, Elsevier Publishing Company, Amsterdam, 1967.Google Scholar
  83. Norberg, B.K., Schmiterloew, C.G., Bergrahm, B., and Lundstroem, H. (1964). Further pathophysiological investigations into the terminal course of experimental anthrax in the rabbit. Acta. Pathol. Microbiol. Scand. 60:108–116.Google Scholar
  84. Office of Public Health Service Historian — National Library of Medicine. (2001). A Brief History of Anthrax. Scholar
  85. Ogata, H., Audic, S., Renesto-Audiffren, P., Fournier, P.E., Barbe, V., Samson, D., Roux, V., Cossart, P., Weissenbach, J., Claverie, J.M., and Raoult, D. (2001). Mechanisms of evolution in Rickettsia conorii and R. prowazekii. Science 293:2093–2098.Google Scholar
  86. Okinaka, R.T., Cloud, K., Hampton, O., Hoffmaster, A.R., Hill, K.K., Keim, P., Koehler, T.M., Lamke, G., Kumano, S., Mahillon, J., Manter, D., Martinez, Y., Ricke, D., Svensson, R., and Jackson, P.J. (1999). Sequence and organization of pXO1, the large Bacillus anthracis plasmid harboring the anthrax toxin genes. J. Bacteriol. 181:6509–6515.PubMedGoogle Scholar
  87. Pellizzari, R., Guidi-Rontani, C., Vitale, G., Mock, M., and Montecucco, C. (1999). Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha. FEBS Lett. 462:199–204.PubMedCrossRefGoogle Scholar
  88. Pile, J.C., Malone J.D., and Etizen, E.M., et al. (1998). Anthrax as a potential biological warfare agent. Arch. Intern. Med. 158:429–434.PubMedCrossRefGoogle Scholar
  89. Plotkin, S.A., Brachman, P.S., Utell, M., Bumford, F.H., and Atchison, M.M. (2002). An epidemic of inhalation anthrax, the first in the twentieth century: clinical features. Am. J. Med. 112:4–12.PubMedCrossRefGoogle Scholar
  90. Pluot, M., Vital, C., Aubertin, J., Croix, J.C., Pire, J.C., and Poisot D. (1976). Anthrax meningitis: report of two cases with autopsies. Acta Neuropathol. 36:339–345.PubMedCrossRefGoogle Scholar
  91. Popov, S.G., Villasmil, R., Bernardi, J., Grene, E., Cardwell, J., Popova, T., Wu, A., Alibek, D., Bailey, C., and Alibek, K. (2002a). Effect of Bacillus anthracis lethal toxin on human peripheral blood mononuclear cells. FEBS Lett. 527:211–215.PubMedCrossRefGoogle Scholar
  92. Popov, S.G., Villasmil, R., Bernardi, J., Grene, E., Cardwell, J., Wu, A., Alibek, D., Bailey, C., and Alibek, K. (2002b). Lethal toxin of Bacillus anthracis causes apoptosis of macrophages. Biochem. Biophys. Res. Commun. 293:349–55.PubMedCrossRefGoogle Scholar
  93. Ramachandran, S., and Natarajan, M. (1968). Tissue response to experimental anthrax of sheep and goats. Indian Vet. J. 45:381–387.PubMedGoogle Scholar
  94. Rangel, R.A., and Gonzalez, D.A. (1975). Bacillus anthracis meningitis. Neurology 25:525–530.PubMedGoogle Scholar
  95. Ray, K.C., Mesnage, S., Washburn, R., Mock, M., Fouet, A., and Blaser, M. (1998). Complement binding to Bacillus anthracis mutants lacking surface structures. Presented at the 98th Annual ASM General Meeting, Atlanta, Georgia.Google Scholar
  96. Read, T.D., Peterson, S.N., Tourasse, N., Baillie, L.W., Paulsen, I.T., Nelson, K.E., Tettelin, H., Fouts, D.E., Eisen, J.A., Gill, S.R., Holtzapple, E.K., Okstad, O.A., Helgason, E., Rilstone, J., Wu, M., Kolonay, J.F., Beanan, M.J., Dodson, R.J., Brinkac, L.M., Gwinn, M., DeBoy, R.T., Madpu, R., Daugherty, S.C., Durkin, A.S., Haft, D.H., Nelson, W.C., Peterson, J.D., Pop, M., Khouri, H.M., Radune, D., Benton, J.L., Mahamoud, Y., Jiang, L., Hance, I.R., Weidman, J.F., Berry, K.J., Plaut, R.D., Wolf, A.M., Watkins, K.L., Nierman, W.C., Hazen, A., Cline, R., Redmond, C., Thwaite, J.E., White, O., Salzberg, S.L., Thomason, B., Friedlander, A.M., Koehler, T.M., Hanna, P.C., Kolsto, A.B., and Fraser, C.M. (2003). The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria. Nature 423:81–86.PubMedCrossRefGoogle Scholar
  97. Record, B.R., and Wallis, R.G. (1956). Physicochemical examination of polyglutamic acid from Bacillus anthracis grown in vivo. Biochem. J. 63:443–447.PubMedGoogle Scholar
  98. Ross, J.M. (1957). The pathogenesis of anthrax following the administration of spores by the respiratory route. J. Pathol. Bacteriol. 73:485–494.CrossRefGoogle Scholar
  99. Roux, V., Bergoin, M., Lamaze, N., and Raoult, D. (1997). Reassessment of the taxonomic position of Rickettsiella grylli. Int. J. Syst. Bacteriol. 47:1255–1257.PubMedCrossRefGoogle Scholar
  100. Rozen’er, L.A. (1948). Anthrax in Humans. State publisher, Moldova, Kishinev.Google Scholar
  101. Severn, M. (1976). A fatal case of pulmonary anthrax. Br. Med. J. 27:748.CrossRefGoogle Scholar
  102. Shapiro, L.B., and Galinobskoi, C.E. (1923). Anthrax case via inhalation. clin. med. 4:13–14.Google Scholar
  103. Smith, H., Keppie, J., and Stanley, J.L. (1955). The chemical basis of the virulence of B. Anthracis. Br. J. Exp. Pathol. 36:460–472.PubMedGoogle Scholar
  104. Smith, H., and Stoner, H.B. (1967). Anthrax toxic complex. Fed Proc. 26:1554–1557.PubMedGoogle Scholar
  105. Stephens, R.S., Kalman, S., Lammel, C., Fan, J., Marathe, R., Aravind, L., Mitchell, W., Olinger, L., Tatusov, R.L., Zhao, Q., Koonin, E.V., and Davis, R.W. (1998). Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science 282:754–759.PubMedCrossRefGoogle Scholar
  106. Suffin, S. (1978). Inhalation anthrax in a home craftsman. Human Pathol. 9:594–597.CrossRefGoogle Scholar
  107. Swartz, M.N. (2001). Recognition and management of anthrax—an update. N. Engl. J. Med. 345(22):1621–1626.PubMedCrossRefGoogle Scholar
  108. Teacher, J.H., and Glasg, M.D. (1906). Primary intestinal anthrax in man; septicemia; haemorrhagic lepto-meningitis. Lancet 12:1306–1311.CrossRefGoogle Scholar
  109. Thorne, C.B. (1993). Bacillus anthracis. In: Sonenshein, A.L., Hoch, J.A., and Losick, R. (eds.), Bacillus subtilis and Other Gram-positive Bacteria. Washington, D.C., ASM, pp. 113–124.Google Scholar
  110. Vessal, K. (1975). Radiological changes in inhalational anthrax. A report of radiological and patological corellations in two cases. Clin. Radiol. 26:471–474.PubMedCrossRefGoogle Scholar
  111. Vitale, G., Pellizzari, R., Recchi, C., Napolitani, G., Mock, M., and Montecucco, C. (1998). Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages. Biochem. Biophys. Res. Commun. 248:706–711.PubMedCrossRefGoogle Scholar
  112. Walker, J.S., Lincoln, R.E., and Klein, F. (1967). Pathophysiological and biochemical changes in anthrax. Fed Proc. 26:1539–1544.PubMedGoogle Scholar
  113. Wang, T.T., Fellows, P.F., Leighton, T.J., and Lucas, A.H. (2004). Induction of opsonic antibodies to the gamma-D-glutamic acid capsule of Bacillus anthracis by immunization with a synthetic peptidecarrier protein conjugate. FEMS Immunol. Med. Microbiol. 40:231–237.PubMedCrossRefGoogle Scholar
  114. Welkos, S.L., Keener, T.J., and Gibbs, P.H. (1986). Differences in susceptibility of inbred mice to Bacillus anthracis. Infect. Immun. 51:795–800.PubMedGoogle Scholar
  115. WHO Model G for PCR detection of Bacillus anthracis, Standard Operating Procedure. WHO Website. (2004). Scholar
  116. Witkowski, J.A. (2002). The story of anthrax from antiquity to present: a biological weapon of nature and humans. Clin. Dermatol. 20:336–242.PubMedCrossRefGoogle Scholar
  117. Zaucha, G.M., Pitt, L.M., Estep, J., Ivins, B.E., and Friedlander, A.M. (1998). The pathology of experimental anthrax in rabbits exposed by inhalation and subcutaneous inoculation. Arch. Pathol. Lab. Med. 122:982–992.PubMedGoogle Scholar
  118. Zimmerman, B.E., and Zimmerman, D.J. (2003). Killer Germs: Microbes and Diseases that Threaten Humanity. Contemporary Books, New York, p. 219.Google Scholar
  119. Zwartouw, H.T., and Smith, H. (1956). Polyglutamic acid from Bacillus anthracis grown in vivo: structure and aggressin activity. Biochem. J. 63:437–454.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Kenneth Alibek
    • 1
  • Catherine Lobanova
    • 1
  • Serguei Popov
    • 1
  1. 1.The National Center for BiodefenseGeorge Mason UniversityManassas

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