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Fluorescence-based Nitric Oxide Detection

  • Chapter
Topics in Fluorescence Spectroscopy

Part of the book series: Topics in Fluorescence Spectroscopy ((TIFS,volume 9))

Abstract

Nitric oxide (NO) is a neutral free radical gas. The NO molecule has long been recognized as an environmental contaminant and a potential health hazard in the atmosphere. It was not until recently that beneficial roles for NO were discovered in biological systems.1–3 In the years since the groundbreaking discovery of NO signaling in biology, further work has shown that NO is a ubiquitous messenger in the cardiovascular, immune, and nervous systems.1,4–12 Even though NO is a relatively stable species with reported half-lives under physiological conditions of up to five seconds,5, 13, 14 it readily reacts with a variety of species commonly found in living organisms. The targets of NO include dioxygen, oxygen radicals, thiols, amines, and transition metal ions. The reactions of NO with dioxygen and superoxide result in formation of reactive nitrogen oxide species (RNOS) NO2 and ONOO−, respectively. Both products are more reactive than NO itself In aqueous environments, the reactions of NO with dioxygen can also yield NO2.

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Authors and Affiliations

  1. Department of Chemistry, Massachusetts Institute if Technology, 77 Massachusetts Avenue, Cabridge, MA, 02139

    Scott A. Hilderbrand, Mi Hee Lim & Stephen J. Lippard

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  1. Scott A. Hilderbrand
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  2. Mi Hee Lim
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  3. Stephen J. Lippard
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Correspondence to Stephen J. Lippard .

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  1. The Institute of Fluorescence Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, Maryland

    Chris D. Geddes

  2. Center for Fluorescence Spectroscopy and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland

    Joseph R. Lakowicz

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Hilderbrand, S.A., Lim, M.H., Lippard, S.J. (2005). Fluorescence-based Nitric Oxide Detection. In: Geddes, C.D., Lakowicz, J.R. (eds) Topics in Fluorescence Spectroscopy. Topics in Fluorescence Spectroscopy, vol 9. Springer, Boston, MA. https://doi.org/10.1007/0-387-23335-0_4

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