The molecular mechanisms underlying most diseases, including those of the cardiovascular system, are widely unknown. Basically, pathological changes in the organism arise from protein alterations. Proteomics comprises a set of tools allowing the identification of protein alterations, i.e. changes of protein abundance and posttranslational modifications, associated with diseases. The linkage of information about such protein changes with functional alterations as revealed by physiological studies constitutes functional proteomics that enables the disclosure of disease mechanisms.
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© 2006 Springer Science+Business Media, Inc
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Scobioala, S., Klocke, R., Michel, G., Nikol, S. (2006). Proteomics: State of the Art and Its Relevance for Gene Therapy. In: Pasterkamp, G., de Kleijn, D.P.V. (eds) Cardiovascular Research. Springer, Boston, MA. https://doi.org/10.1007/0-387-23329-6_2
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DOI: https://doi.org/10.1007/0-387-23329-6_2
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