5. Conclusions
The effects of inositol polyphosphates on ion flux in CF mucosa described here suggest a novel therapeutic approach to the treatment of cystic fibrosis. These studies indicate that transient exposure to an inositol polyphosphate analog, INO-4995, causes long lasting but ultimately reversible changes in therapeutically relevant electrophysiological properties of CF human nasal epithelia. This avoids a major problem encountered with other ion channel regulators that have been advanced as potential CF treatments, limited duration of action.
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Traynor-Kaplan, A., Moody, M., Schultz, C. (2005). An Inositol Phosphate Analog, INO-4995, Normalizes Electrophysiology in CF Airway Epithelia. In: Schultz, C. (eds) Defects of Secretion in Cystic Fibrosis. Advances in Experimental Medicine and Biology, vol 558. Springer, Boston, MA. https://doi.org/10.1007/0-387-23250-8_9
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