5. Concluding Remarks
The typical CF symptoms with viscous and trapped mucus are still lacking a full explanation. Here we suggest that the CF mucus become sticky and adherent to the epithelial cells by a covalent attachment of MUC2 and MUC5AC. We also suggest that the expression of MUC2 in the lungs could contribute to the CF phenotype. However, there are several unanswered questions before these suggestions can be proved. Among the most urgent ones are to show to what molecules the generated anhydride can attach or if the anhydride only has been hydrolyzed. Once this and other questions have been answered, one can start to address potential therapeutic approaches using recent advances in mucin knowledge.
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Hansson, G.C., Johansson, M.E.V., Lidell, M.E. (2005). Biosynthesis and Secretion of Mucins, Especially the MUC2 Mucin, in Relation to Cystic Fibrosis. In: Schultz, C. (eds) Defects of Secretion in Cystic Fibrosis. Advances in Experimental Medicine and Biology, vol 558. Springer, Boston, MA. https://doi.org/10.1007/0-387-23250-8_12
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