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Molecular Mechanisms in Deafness Related Auditory Brain Stem Plasticity

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Plasticity and Signal Representation in the Auditory System

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4. Conclusions

There is considerable capacity for plasticity in the mature auditory brain stem and plastic changes can be evoked by the change in activity resulting from profound deafness. There are deafness related changes in transmitters and receptors with resulting changes in inhibition and activity that can effect auditory processing. An understanding of the underlying mechanisms of plasticity, with gene microarray results pointing to a number of regulatory pathways, could help in development of interventions to influence plasticity. Such interventions should be helpful to provide the best circumstances for return of hearing with cochlear prostheses following deafness as well as for management of clinical problems resulting from the plasticity of partial deafness and central tinnitus.

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Authors and Affiliations

  1. Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan

    Richard A. Altschuler, Avril Genene Holt, Mikiya Asako, Catherine A. Lomax & Margaret I. Lomax

  2. Catedrático de Histologia, Universidad de Castilla-La-Mancha, Albacete, Spain

    Jose Juiz

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  1. Richard A. Altschuler
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  2. Avril Genene Holt
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  1. Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic

    Josef Syka

  2. Keck Center for Integrative Neurosciences, University of California at San Francisco, San Francisco, California

    Michael M. Merzenich

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Altschuler, R.A., Holt, A.G., Asako, M., Lomax, C.A., Lomax, M.I., Juiz, J. (2005). Molecular Mechanisms in Deafness Related Auditory Brain Stem Plasticity. In: Syka, J., Merzenich, M.M. (eds) Plasticity and Signal Representation in the Auditory System. Springer, Boston, MA . https://doi.org/10.1007/0-387-23181-1_9

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