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Proteases in CNS Infection and Inflammation

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Proteases In The Brain

Part of the book series: Proteases In Biology and Disease ((PBAD,volume 3))

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REFERENCES

  • Ahmed Z, Doward AI, Pryce G, Taylor DL, Pocock JM, Leonard JP, Baker D, Cuzner ML, 2002, A role for caspase-1 and-3 in the pathology of experimental allergic encephalomyelitis-Inflammation versus degeneration. Am J Pathol. 161:1577–1586.

    CAS  PubMed  Google Scholar 

  • Amour A, Knight CG, Webster A, Slocombe PM, Stephens PE, Knäuper V, Docherty AJP, Murphy G, 2000, The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3. FEBS lett. 473:275–279.

    Article  CAS  PubMed  Google Scholar 

  • Anthony DC, Miller KM, Fearn S, Townsend MJ, Opdenakker G, Wells GMA, Clements JM, Chandler S, Gearing AJH, Perry VH, 1998, Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS.J Neuroimmunol. 87:62–72.

    Article  CAS  PubMed  Google Scholar 

  • Bajramovic JJ, Plomp AC, van der Goes A, Koevoets C, Newcombe J, Cuzner ML, van Noort JM, 2000, Presentation of alpha B-crystallin to T cells in active multiple sclerosis lesions: An early event following inflammatory demyelination. J Immunol. 164:4359–4366.

    CAS  PubMed  Google Scholar 

  • Baraett MH, Prineas JW, 2004, Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion. Ann Neurol. 55:458–468.

    Google Scholar 

  • Bar-Or A, Nuttall RK, Duddy M, Alter A, Kim HJ, Ifergan I, Pennington CJ, Bourgoin P, Edwards DR, Yong VW, 2003, Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. Brain. 126:2738–2749.

    Article  PubMed  Google Scholar 

  • Beck H, Schwarz G, Schroter CJ, Deeg M, Baier D, Stevanovic S, Weber E, Driessen C, Kalbacher H, 2001, Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro. Eur J Immunol. 31:3726–3736.

    Article  CAS  PubMed  Google Scholar 

  • Benjamins JA, Nedelkoska L, George EB, 2003, Protection of mature oligodendrocytes by inhibitors of caspases and calpains. Neurochem Res. 28:143–152.

    Article  CAS  PubMed  Google Scholar 

  • Bernal F, Graus F, Pifarre A, Saiz A, Benyahia B, Ribalta T, 2002, Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis. Acta Neuropathol (Berl). 103:509–515.

    CAS  Google Scholar 

  • Bever CT, Garver DW, 1995, Increased cathepsin-B activity in multiple sclerosis brain. J Neurol Sci. 131:71–73.

    Article  PubMed  Google Scholar 

  • Bifrare YD, Gianinazzi C, Imboden H, Leib SL, Tauber MG, 2003, Bacterial meningitis causes two distinct forms of cellular damage in the hippocampal dentate gyrus in infant rats. Hippocampus. 13:481–488.

    Article  PubMed  Google Scholar 

  • Birkedal-Hansen H, 1995, Proteolytic remodeling of extracellular matrix. Curr Opin Cell Biol. 7:728–735.

    Article  CAS  PubMed  Google Scholar 

  • Black RA, 2002, Tumor necrosis factor-alpha converting enzyme. Int J Biochem Cell Biol. 34:1–5.

    Article  CAS  PubMed  Google Scholar 

  • Black RA, Rauch CT, Kozlosky CJ, Peschon JJ, Slack JL, Wolfson MF, Castner BJ, Stocking KL, Reddy P, Srinivasan S, Nelson N, Boiani N, Schooley KA, Gerhart M, Davis R, Fitzner JN, Johnson RS, Paxton RJ, March CJ, Cerretti DP, 1997, A metalloproteinase disintegrin that releases tumor-necrosis factor-α from cells. Nature. 385:729–733.

    Article  CAS  PubMed  Google Scholar 

  • Bottcher T, Spreer A, Azeh I, Nau R, Gerber J, 2003, Matrix metalloproteinase-9 deficiency impairs host defense mechanisms against Streptococcus pneumoniae in a mouse model of bacterial meningitis. Neurosci Lett. 338:201–204.

    Article  CAS  PubMed  Google Scholar 

  • Braun JS, Novak R, Herzog KH, Bodner SM, Cleveland JL, Tuomanen EI, 1999, Neuroprotection by a caspase inhibitor in acute bacterial meningitis. Nat Med. 5:298–302.

    CAS  PubMed  Google Scholar 

  • Brundula V, Rewcastle NB, Metz LM, Bernard CC, Yong VW, 2002, Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis. Brain. 125:1297–1308.

    Article  PubMed  Google Scholar 

  • Burster T, Beck A, Tolosa E, Marin-Esteban V, Rotzschke O, Falk K, Lautwein A, Reich M, Brandenburg J, Schwarz G, Wiendl H, Melms A, Lehmann R, Stevanovic S, Kalbacher H, Driessen C, 2004, Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes. J Immunol. 172:5495–5503.

    CAS  PubMed  Google Scholar 

  • Cannella B, Raine CS, 2004, Multiple sclerosis: Cytokine receptors on oligodendrocytes predict innate regulation. Ann Neurol. 55:46–57.

    Article  CAS  PubMed  Google Scholar 

  • Chabas D, Baranzini SE, Mitchell D, Bernard CC, Rittling SR, Denhardt DT, Sobel RA, Lock C, Karpuj M, Pedotti R, Heller R, Oksenberg JR, Steinman L, 2001, The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science. 294:1731–1735.

    Article  CAS  PubMed  Google Scholar 

  • Chandler S, Miller KM, Clements JM, Lury J, Corkill D, Anthony DCC, Adams SE, Gearing AJH, 1997, Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview. J Neuroimmunol. 72:155–161.

    Article  CAS  PubMed  Google Scholar 

  • Cid C, Alvarez-Cermeno JC, Regidor I, Plaza J, Salinas M, Alcazar A, 2003, Caspase inhibitors protect against neuronal apoptosis induced by cerebrospinal fluid from multiple sclerosis patients. J Neuroimmunol. 136:119–124.

    Article  CAS  PubMed  Google Scholar 

  • Clements JM, Cossins JA, Wells GMA, Corkill DJ, Helfrich K, Wood LM, Pigott R, Stabler G, Ward GA, Gearing AJH, Miller KM, 1997, Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumor necrosis factor-α inhibitor. J Neuroimmunol. 74:85–94.

    Article  CAS  PubMed  Google Scholar 

  • Corasaniti MT, Navarra M, Catani MV, Melino G, Nistico G, FinazziAgro A, 1996, NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain. Biochem Biophys Res Commun. 229:299–304.

    Article  CAS  PubMed  Google Scholar 

  • Cuzner ML, Gveric D, Strand C, Loughlin AJ, Paemen L, Opdenakker G, Newcombe J, 1996, The expression of tissue-type plasminogen activator, matrix metalloproteases and endogenous inhibitors in the central nervous system in multiple sclerosis: comparison of stages in lesion evolution. J Neuropathol Exp Neurol. 55:1194–1204.

    CAS  PubMed  Google Scholar 

  • Deshpande RV, Goust JM, Hogan EL, Banik NL, 1995, Calpain secreted by activated human lymphoid cells degrades myelin. J Neurosci Res. 42:259–265.

    Article  CAS  PubMed  Google Scholar 

  • Dinkel K, Dhabhar FS, Sapolsky RM, 2004, Neurotoxic effects of polymorphonuclear granulocytes on hippocampal primary cultures. Proc Natl Acad Sci USA. 101:331–336.

    CAS  PubMed  Google Scholar 

  • Drexler HCA, 1998, Programmed cell death and the proteasome. Apoptosis. 3:1–7.

    Article  CAS  PubMed  Google Scholar 

  • Dubois B, Masure S, Hurtenbach U, Paemen L, Heremans H, van den Oord J, Sciot R, Meinhardt T, Hämmerling G, Opdenakker G, Arnold B, 1999, Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions. J Clin Invest. 104:1507–1515.

    CAS  PubMed  Google Scholar 

  • Eto K, Puzon-McLaughlin W, Sheppard D, Sehara-Fujisawa A, Zhang XP, Takada Y, 2000, RGD-independent binding of integrin alpha9betal to the ADAM-12 and-15 disintegrin domains mediates cell-cell interaction. J Biol Chem. 275:34922–34930.

    Article  CAS  PubMed  Google Scholar 

  • Faber M, Pulmanausahakul R, Hodawadekar SS, Spitsin S, McGettigan JP, Schnell MJ, Dietzschold B, 2002, Overexpression of the rabies virus glycoprotein results in enhancement of apoptosis and antiviral immune response. J Virol. 76:3374–3381.

    Article  CAS  PubMed  Google Scholar 

  • Fantuzzi G, Dinarello CA, 1999, Interleukin-18 and interleukin-1 beta: Two cytokine substrates for ICE (Caspase-1). J Clin Immunol. 19:1–11.

    Article  CAS  PubMed  Google Scholar 

  • Franciotta D, Martino G, Zardini E, Furlan R, Bergamaschi R, Gironi M, Bergami A, Angelini G, De Benedetti F, Pignatti P, Moscato G, Cosi V, 2002, Caspase-1 levels in biological fluids from patients with multiple sclerosis and from patients with other neurological and non-neurological diseases. Eur Cytokine Netw. 13:99–103.

    CAS  PubMed  Google Scholar 

  • Frei K, Eugster H-P, Bopst M, Constantinescu CS, Lavi E, Fontana A, 1997, Tumor necrosis factor α and lymphotoxin α are not required for induction of acute experimental autoimmune encephalomyelitis. J Exp Med. 185:2177–2182.

    Article  CAS  PubMed  Google Scholar 

  • Furlan R, Filippi M, Bergami A, Rocca MA, Martinelli V, Poliani PL, Grimaldi LME, Desina G, Comi G, Martino G, 1999a, Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study. J Neurol Neurosurg Psychiatr. 67:785–788.

    CAS  PubMed  Google Scholar 

  • Furlan R, Martino G, Galbiati F, Poliani PL, Smiroldo S, Bergami A, Desina G, Comi G, Flavell R, Su MS, Adorini L, 1999b, Caspase-1 regulates the inflammatory process leading to autoimmune demyelination. J Immunol. 163:2403–2409.

    CAS  PubMed  Google Scholar 

  • Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D’Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA, 2002, Caspase cascades in human immunodeficiency virus-associated neurodegeneration. J Neurosci. 22:4015–4024.

    CAS  PubMed  Google Scholar 

  • Gerber J, Bruck W, Stadelmann C, Bunkowski S, Lassmann H, Nau R, 2001, Expression of death-related proteins in dentate granule cells in human bacterial meningitis. Brain Pathol. 11:422–431.

    CAS  PubMed  Google Scholar 

  • Gianinazzi C, Grandgirard D, Imboden H, Egger L, Meli DN, Bifrare YD, Joss PC, Tauber MG, Borner C, Leib SL, 2003, Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis. Acta Neuropathol (Berl). 105:499–507.

    CAS  Google Scholar 

  • Gijbels K, Masure S, Carton H, Opdenakker G, 1992, Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatoryneurological disorders. J Neuroimmunol. 41:29–34.

    Article  CAS  PubMed  Google Scholar 

  • Gijbels K, Proost P, Carton H, Billiau A, Opdenakker G, 1993, Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein. J Neurosci Res. 36:432–440.

    Article  CAS  PubMed  Google Scholar 

  • Goddard DR, Bunning RA, Woodroofe MN, 2001, Astrocyte and endothelial cell expression of ADAM 17 (TACE) in adult human CNS. Glia. 34:267–271.

    Article  CAS  PubMed  Google Scholar 

  • Gold R, Hartung H-P, Toyka KV, 2000, Animal models for autoimmune demyelinating disorders of the nervous system. Mol Med Today. 6:88–91.

    CAS  PubMed  Google Scholar 

  • Goll DE, Thompson VF, Li HQ, Wei W, Cong JY, 2003, The calpain system. Physiol Rev. 83:731–801.

    CAS  PubMed  Google Scholar 

  • Gomes AC, Jonsson G, Mjornheim S, Olsson T, Hillert J, Grandien A, 2003, Upregulation of the apoptosis regulators cFLIP, CD95 and CD95 ligand in peripheral blood mononuclear cells in relapsing-remitting multiple sclerosis. J Neuroimmunol. 135:126–134.

    Article  CAS  PubMed  Google Scholar 

  • Gottschall PE, Deb S, 1996, Regulation of matrix metalloproteinase expressions in astrocytes, microglia and neurons. Neuroimmunomodulation. 3:69–75.

    CAS  PubMed  Google Scholar 

  • Hemmer B, Archelos JJ, Hartung HP, 2002, New concepts in the immunopathogenesis of multiple sclerosis. Nature Rev Neurosci. 3:291–201.

    CAS  Google Scholar 

  • Hisahara S, Okano H, Miura M, 2003, Caspase-mediated oligodendrocyte cell death in the pathogenesis of autoimmune demyelination. Neurosci Res. 46:387–397.

    Article  CAS  PubMed  Google Scholar 

  • Hisahara S, Yuan JY, Momoi T, Okano H, Miura M, 2001, Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination. J Exp Med. 193:111–122.

    Article  CAS  PubMed  Google Scholar 

  • Hofman FM, Hinton DR, Johnson K, Merrill JE, 1989, Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med. 70:607–612.

    Google Scholar 

  • Holtzman MJ, Green JM, Jayaraman S, Arch RH, 2000, Regulation of T cell apoptosis. Apoptosis. 5:459–471.

    Article  CAS  PubMed  Google Scholar 

  • Howard L, Lu X, Mitchell S, Griffiths S, Glynn P, 1996, Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types. Biochem J. 317:45–50.

    CAS  PubMed  Google Scholar 

  • Iba K, Albrechtsen R, Gilpin B, Frohlich C, Loechel F, Zolkiewska A, Ishiguro K, Kojima T, Liu W, Langford JK, Sanderson RD, Brakebusch C, Fassler R, Wewer UM, 2000, The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to betal integrin-dependent cell spreading. J Cell Biol. 149:1143–1156.

    Article  CAS  PubMed  Google Scholar 

  • Johnson DE, 2000, Noncaspase proteases in apoptosis. Leukemia. 14:1695–1703.

    CAS  PubMed  Google Scholar 

  • Kang SJ, Wang S, Kuida K, Yuan J, 2002, Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response. Cell Death Differ. 9:1115–1125.

    Article  CAS  PubMed  Google Scholar 

  • Kanwar JR, Kanwar RK, Krissansen GW, 2004, Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis. Brain. 127:1313–1331.

    Article  PubMed  Google Scholar 

  • Kieseier BC, Kiefer R, Clements JM, Miller K, Wells GMA, Schweitzer T, Gearing AJH, Hartung H-P, 1998, Matrix metalloproteinase-9 and-7 are regulated in experimental autoimmune encephalomyelitis. Brain. 121:159–166.

    Article  PubMed  Google Scholar 

  • Kieseier BC, Paul R, Koedel U, Seifert T, Clements JM, Gearing AJH, Pfister HW, Hartung H-P, 1999a, Differential expression of matrix metalloproteinases in bacterial meningitis. Brain. 122:1579–1587.

    Article  PubMed  Google Scholar 

  • Kieseier BC, Pischel H, Neuen-Jacob E, Tourtellotte WW, Hartung HP, 2003, ADAM-10 and ADAM-17 in the inflamed human CNS. Glia. 42:398–405.

    Article  PubMed  Google Scholar 

  • Kieseier BC, Seifert T, Giovannoni G, Hartung H-P, 1999b, Matrix metalloproteinases in inflammatory demyelination. Targets for treatment. Neurology. 53:20–25.

    CAS  PubMed  Google Scholar 

  • Kingham PJ, Pocock JM, 2001, Microglial secreted cathepsin B induces neuronal apoptosis. J Neurochem. 76:1475–1484.

    Article  CAS  PubMed  Google Scholar 

  • Koedel U, Bayerlein I, Paul R, Sporer B, Pfister HW, 2000, Pharmacologic interference with NF-kappa B activation attenuates central nervous system complications in experimental pneumococcal meningitis. J Infect Dis. 182:1437–1445.

    Article  CAS  PubMed  Google Scholar 

  • Koedel U, Winkler F, Angele B, Fontana A, Flavell RA, Pfister HW, 2002, Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice. Ann Neurol. 51:319–329.

    Article  CAS  PubMed  Google Scholar 

  • Kolb SA, Lahrtz F, Paul R, Leppert D, Nadal D, Pfister HW, Fontana A, 1998, Matrix metalloproteinases and tissue inhibitors of metalloproteinases in viral meningitis: upregulation of MMP-9 and TIMP-1 in cerebrospinal fluid. J Neuroimmunol. 84:143–150.

    Article  CAS  PubMed  Google Scholar 

  • Körner H, Riminton DS, Strickland DH, Lemckert FA, Pollard JD, Sedgwick JD, 1997, Critical points in tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting. J Exp Med. 186:1585–1590.

    PubMed  Google Scholar 

  • Lassmann H, 2000, Neuropathology in multiple sclerosis: new concepts. Mult Scler. 4:93–98.

    Google Scholar 

  • Lee KY, Kim EH, Yang WS, Ryu H, Cho SN, Lee BI, Heo JH, 2004, Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis. J Neurol Sci. 220:73–78.

    Article  CAS  PubMed  Google Scholar 

  • Lee MA, Palace J, Stabler G, Ford J, Gearing A, Miller K, 1999, Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis: a longitudinal clinical and MRI study. Brain. 122:191–197.

    PubMed  Google Scholar 

  • Leib SL, Clements JM, Lindberg RL, Heimgartner C, Loeffler JM, Pfister LA, Tauber MG, Leppert D, 2001, Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain. 124:1734–1742.

    Article  CAS  PubMed  Google Scholar 

  • Leppert D, Ford J, Stabler G, Grygar C, Lienert C, Huber S, Miller KM, Hauser SL, Kappos L, 1998, Matrix metalloproteinase-9 (gelatinase B) is electively elevated in CSF during relapses and stable phases of multiple sclerosis. Brain. 121:2327–2334.

    Article  PubMed  Google Scholar 

  • Leppert D, Leib SL, Grygar C, Miller KM, Schaad UB, Hollander GA, 2000, Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae. Clin Infect Dis. 31:80–84.

    Article  CAS  PubMed  Google Scholar 

  • Leppert D, Waubant E, Galardy R, Bunnett NW, Hauser SL, 1995, T cell gelatinases mediate basement membrane transmigration in vitro. J Immunol. 154:4379–4389.

    CAS  PubMed  Google Scholar 

  • Liedtke W, Cannella B, Mazzaccaro RJ, Clements JM, Miller KM, Wucherpfennig KW, Gearing AJH, Raine CS, 1998, Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. Ann Neurol. 44:35–46.

    Article  CAS  PubMed  Google Scholar 

  • Liu HN, Giasson BI, Mushynski WE, Almazan G, 2002, AMPA receptor-mediated toxicity in oligodendrocyte progenitors involves free radical generation and activation of JNK, calpain and caspase 3. J.Neurochem. 82:398–409.

    Article  CAS  PubMed  Google Scholar 

  • Liu J, Marino MW, Wong G, Grail D, Dunn A, Bettadapura J, Slavin AJ, Old L, Bernard CCA, 1998, TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nature Med. 4:78–83.

    CAS  PubMed  Google Scholar 

  • Liuzzo JP, Petanceska SS, Moscatelli D, Devi LA, 1999, Inflammatory mediators regulate cathepsin S in macrophages and microglia: A role in attenuating heparan sulfate interactions. Mol Med. 5:320–333.

    CAS  PubMed  Google Scholar 

  • Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H, 2000, Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Ann Neurol. 47:707–717.

    Article  CAS  PubMed  Google Scholar 

  • Lutton JD, Winston R, Rodman TC, 2004, Multiple sclerosis: etiological mechanisms and future directions. Exp Biol Med. 229:12–20.

    CAS  Google Scholar 

  • Macchi B, Matteucci C, Nocentini U, Caltagirone C, Mastino A, 1999, Impaired apoptosis in mitogen-stimulated lymphocytes of patients with multiple sclerosis. Neuroreport. 10:399–402.

    CAS  PubMed  Google Scholar 

  • Maeda A, Sobel RA, 1996, Matrix metalloproteinases in the normal human central nervous system, microglial nodules, and multiple sclerosis lesions. J Neuropathol Exp Neurol. 55:300–309.

    CAS  PubMed  Google Scholar 

  • Mandler RN, Dencoff JD, Midani F, Ford CC, Ahmed W, Rosenberg GA, 2001, Matrix metalloproteinases and tissue inhibitors of metalloproteinases in cerebrospinal fluid differ in multiple sclerosis and Devic’s neuromyelitis optica. Brain. 124:493–498.

    Article  CAS  PubMed  Google Scholar 

  • Matute C, Alberdi E, Domercq M, Perez-Cerda F, Perez-Samartin A, Sanchez-Gomez MV, 2001, The link between excitotoxic oligodendroglial death and demyelinating diseases. Trends Neurosci. 24:224–230.

    Article  CAS  PubMed  Google Scholar 

  • Meli DN, Christen S, Leib SL, 2003, Matrix metalloproteinase-9 in pneumococcal meningitis: activation via an oxidative pathway. J Infect Dis. 187:1411–1415.

    Article  CAS  PubMed  Google Scholar 

  • Meli DN, Loeffler JM, Baumann P, Neumann U, Buhl T, Leppert D, Leib SL, 2004, In pneumococcal meningitis a novel water-soluble inhibitor of matrix metalloproteinases and TNF-alpha converting enzyme attenuates seizures and injury of the cerebral cortex. J Neuroimmunol. 151:6–11.

    Article  CAS  PubMed  Google Scholar 

  • Meyer R, Weissert R, Diem R, Storch MK, de Graaf KL, Kramer B, Bahr M, 2001, Acute neuronal apoptosis in a rat model of multiple sclerosis. J Neurosci. 21:214–6220.

    Google Scholar 

  • Ming X, Li W, Maeda Y, Blumberg B, Raval S, Cook SD, Dowling PC, 2002, Caspase-1 expression in multiple sclerosis plaques and cultured glial cells. J Neurol Sci. 197:9–18.

    Article  CAS  PubMed  Google Scholar 

  • Murphy G, Willenbrock F, Crabbe T, O’shea M, Ward R, Atkinson S, O’Connell J, Docherty A, 1994, Regulation of matrix metalloproteinase activity. Ann N Y Acad Sci. 732:31–41.

    CAS  PubMed  Google Scholar 

  • Nagai A, Murakawa Y, Terashima M, Shimode K., Umegae N, Takeuchi H, Kobayashi S, 2000, Cystatin C and cathepsin B in CSF from patients with inflammatory neurologic diseases. Neurology. 55:1828–1832.

    CAS  PubMed  Google Scholar 

  • Nath D, Slocombe PM, Webster A, Stephens PE, Docherty AJ, Murphy G, 2000, Meltrin gamma (ADAM-9) mediates cellular adhesion through alpha(6)beta(1) integrin, leading to amarked induction of fibroblast cell motility. J Cell Sci. 113:2319–2328.

    CAS  PubMed  Google Scholar 

  • Nau R, Soto A, Bruck W, 1999, Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis. J Neuropathol Exp Neurol. 58:265–274.

    CAS  PubMed  Google Scholar 

  • Neumar RW, Xu YA, Gada H, Guttmann RP, Siman R, 2003, Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis. J Biol Chem. 278:14162–14167.

    Article  CAS  PubMed  Google Scholar 

  • Overall CM, 1994, Regulation of tissue inhibitor of matrix metalloproteinase expression. Ann N Y Acad Sci. 732:51–64.

    CAS  PubMed  Google Scholar 

  • Pagenstecher A, Stalder AK, Kincaid CL, Shapiro SD, Campbell IL, 1998, Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states. Am J Pathol. 152:729–741.

    CAS  PubMed  Google Scholar 

  • Paivalainen S, Suokas M, Lahti O, Heape AM, 2003, Degraded myelin-associated glycoprotein (dMAG) formation from pure human brain myelin-associated glycoprotein (MAG) is not mediated by calpain or cathepsin L-like activities. J Neurochem. 84:533–545.

    Article  CAS  PubMed  Google Scholar 

  • Patel CA, Mukhtar M, Pomerantz RJ, 2000, Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cells. J Virol. 74:9717–9726.

    Article  CAS  PubMed  Google Scholar 

  • Paul R, Lorenzl S, Koedel U, Sporer B, Vogel U, Frosch M, Pfister H-W, 1998, Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis. Ann Neurol. 44:592–600.

    Article  CAS  PubMed  Google Scholar 

  • Pearl GS, Mullins RE, 1985, α-antitrypsin in cerebrospinal fluid of patients with neurologic diseases. Arch Neurol. 42:775–777.

    CAS  PubMed  Google Scholar 

  • Pender MP, 1998, Genetically determined failure of activation-induced apoptosis of autoreactive T cells as a cause of multiple sclerosis. Lancet. 351:978–981.

    CAS  PubMed  Google Scholar 

  • Pender MP, Rist MJ, 2001, Apoptosis of inflammatory cells in immune control of the nervous system: roleofglia. Glia. 36:137–144.

    Article  CAS  PubMed  Google Scholar 

  • Pitt D, Werner P, Raine CS, 2000, Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med. 6:67–70.

    CAS  PubMed  Google Scholar 

  • Popovic N, Schubart A, Goetz BD, Zhang SC, Linington C, Duncan ID, 2002, Inhibition of autoimmune encephalomyelitis by a tetracycline. Ann Neurol. 51:215–223.

    Article  CAS  PubMed  Google Scholar 

  • Richardson-Burns SM, Kominsky DJ, Tyler KL, 2002, Reovirus-induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptors. J Neurovirol. 8:365–380.

    CAS  PubMed  Google Scholar 

  • Ries C, Petrides PE, 1995, Cytokine regulation of matrix metalloproteinase activity and its regulatory dysfunction in disease. Biol Chem Hoppe-Seyler. 376:345–355.

    CAS  PubMed  Google Scholar 

  • Robinson WH, DiGennaro C, Hueber W, Haab BB, Kamachi M, Dean EJ, Foumel S, Fong D, Genovese MC, de Vegvar HE, Skriner K, Hirschberg DL, Morris RI, Muller S, Pruijn GJ, van Venrooij J, Smolen JS, Brown PO, Steinman L, Utz PJ, 2002, Autoantigen microarrays for multiplex characterization of autoantibody responses. Nat Med. 8:295–301.

    Article  CAS  PubMed  Google Scholar 

  • Rosenberg GA, Dencoff JE, Correa N, Reiners M, Ford CC, 1996, Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis: relation to blood-brain barrier injury. Neurology. 46:1626–1632.

    CAS  PubMed  Google Scholar 

  • Rosenberg GA, Dencoff JE, McGuire PG, Liotta LA, Stetler-Stevenson WA, 1994, Injury-induced 92-kilodalton gelatinase and urokinase expression in rat brain. Lab Invest. 71:417–422.

    CAS  PubMed  Google Scholar 

  • Rosenberg GA, Kornfeld M, Estrada E, Kelley RO, Liotta LA, Stetler-Stevenson WG, 1992, TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase. Brain Res. 576:203–207.

    Article  CAS  PubMed  Google Scholar 

  • Rozman-Pungercar J, Kopitar-Jerala N, Bogyo M, Turk D, Vasiljeva O, Stefe I, Vandenabeele P, Bromrae D, Puizdar V, Fonovic M, Trstenjak-Prebanda M, Dolenc I, Turk V, Turk B, 2003, Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity. Cell Death Differ. 10:881–888.

    CAS  PubMed  Google Scholar 

  • Sanchez-Gomez MV, Alberdi E, Ibarretxe G, Torre I, Matute C, 2003, Caspase-dependent and caspase-independent oligodendrocyte death mediated by AMPA and kainate receptors. J Neurosci. 23:9519–9528.

    CAS  PubMed  Google Scholar 

  • Schaecher K, Rocchini A, Dinkins J, Matzelle DD, Banik NL, 2002, Calpain expression and infiltration of activated T cells in experimental allergic encephalomyelitis over time: increased calpain activity begins with onset of disease. J Neuroimmunol. 129:1–9.

    Article  CAS  PubMed  Google Scholar 

  • Schaecher K.E, Shields DC, Banik NL, 2001, Mechanism of myelin breakdown in experimental demyelination: A putative role for calpain. Neurochem Res. 26:731–737.

    Article  CAS  PubMed  Google Scholar 

  • Schlondorff J, Blobel CP, 1999, Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. J Cell Sci. 112:3603–3617.

    CAS  PubMed  Google Scholar 

  • Seidi OA, Sharief MK, 2002, The expression of apoptosis-regulatory proteins in B lymphocytes from patients with multiple sclerosis. J Neuroimmunol. 130:202–210.

    Article  CAS  PubMed  Google Scholar 

  • Selmaj K, S RC, Cannella B, Brosnan CF, 1991, Identification of lymphtoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest. 87:949–954.

    CAS  PubMed  Google Scholar 

  • Semra YK, Seidi OA, Sharief MK, 2001, Overexpression of the apoptosis inhibitor FLIP in T cells correlates with disease activity in multiple sclerosis. J Neuroimmunol. 113:268–274.

    Article  CAS  PubMed  Google Scholar 

  • Shapiro S, Miller A, Lahat N, Sobel E, Lerner A, 2003, Expression of matrix metalloproteinases, sICAM-1 and IL-8 in CSF from children with meningitis. J Neurol Sci. 206:43–48.

    Article  CAS  PubMed  Google Scholar 

  • Shields DC, Banik NL, 1998, Putative role of calpain in the pathophysiology of experimental optic neuritis. Exp Eye Res. 67:403–410.

    Article  CAS  PubMed  Google Scholar 

  • Shields DC, Schaecher KE, Saido TC, Banik NL, 1999, A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain. Proc Natl Acad Sci USA. 96:11486–11491.

    Article  CAS  PubMed  Google Scholar 

  • Shields DC, Tyor WR, Deibler GE, Hogan EL, Banik NL, 1998, Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis. Proc Natl Acad Sci USA. 95:5768–5772.

    Article  CAS  PubMed  Google Scholar 

  • Stebbins JW, Jaffe H, Moller JR, 1998, Characterization of myelin-associated glycoprotein (MAG) proteolysis in the human central nervous system. Neurochem Res. 23:1005–1010.

    Article  CAS  PubMed  Google Scholar 

  • Steinman L, Martin R, Bernard C, Conlon P, Oksenberg JR, 2002, Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy. Annu Rev Neurosci. 25: 491–505.

    Article  CAS  PubMed  Google Scholar 

  • Stetler-Stevenson WG, Krutzsch HC, Liotta LA, 1989, Tissue inhibitor of metalloproteinase (TIMP-2): a new member of the metalloproteinase inhibitor family. J Biol Chem. 264: 17374–17378.

    CAS  PubMed  Google Scholar 

  • Stüve O, Dooley NP, Uhm JH, Antel JP, Francis GS, Wiliams G, Yong VW, 1996, Interferon â–¡-b decreases the migration of T lymphocytes in vitro: effects on matrix-metalloproteinase-9. Ann Neurol. 40:53–863.

    Google Scholar 

  • Takano M, Hone M, Yayama K, Okamoto H, 2003, Lipopolysaccharide injection into the cerebral ventricle evokes kininogen induction in the rat brain. Brain Res. 978:72–82.

    Article  CAS  PubMed  Google Scholar 

  • Takino T, Sato H, Yamamoto E, Seiki M, 1995, Cloning of a human gene potentially encoding a novel matrix metalloproteinase having a C-terminal transmembrane domain. Gene. 155:293–298.

    Article  CAS  PubMed  Google Scholar 

  • Thornberry NA, Lazebnik Y, 1998, Caspases: Enemies within. Science. 281:1312–1316.

    Article  CAS  PubMed  Google Scholar 

  • Turk V, Turk B, Turk D, 2001, Lysosomal cysteine proteases: facts and opportunities. EMBO J. 20:4629–4633.

    CAS  PubMed  Google Scholar 

  • Uhm JH, Dooley NP, Oh LY, Yong VW, 1998, Oligodendrocytes utilize a matrix metalloproteinase, MMP-9, to extend processes along an astrocyte extracellular matrix. Glia. 22:53–63.

    Article  CAS  PubMed  Google Scholar 

  • von Mering M, Wellmer A, Michel U, Bunkowski S, Tlustochowska A, Brack W, Kuhnt U, Nau R, 2001, Transcriptional regulation of caspases in experimental pneumococcal meningitis. Brain Pathol. 11:282–295.

    Google Scholar 

  • Vos CM, van Haastert ES, de Groot CJ, van der Valk P, de Vries HE, 2003, Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions. J Neuroimmunol. 138:106–114.

    Article  CAS  PubMed  Google Scholar 

  • Wang KKW, 2000, Calpain and caspase: can you tell the difference? Trends Neurosci. 23: 20–26.

    PubMed  Google Scholar 

  • Weskamp G, Cai H, Brodie TA, Higashyama S, Manova K, Ludwig T, Blobel CP, 2002, Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life. Mol Cell Biol. 22:1537–1544.

    Article  CAS  PubMed  Google Scholar 

  • Woessner Jr JF, 1994, The family of matrix metalloproteinases. Ann N Y Acad Sci. 732:11–21.

    CAS  PubMed  Google Scholar 

  • Yamashima T, 2000, Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog Neurobiol. 62:273–295.

    Article  CAS  PubMed  Google Scholar 

  • Yang JS, Ramanathan MP, Muthumani K, Choo AY, Jin SH, Yu QC, Hwang DS, Choo DK, Lee MD, Dang K, Tang W, Kim JJ, Weiner DB, 2002, Induction of inflammation by West Nile virus capsid through the caspase-9 apoptotic pathway. Emerg Infect Dis. 8:1379–1384.

    CAS  PubMed  Google Scholar 

  • Yong VW, Krekoski CA, Forsyth PA, Bell R, Edwards DR, 1998, Matrix metalloproteinases and diseases of the CNS. Trends Neurosci. 21:75–80.

    CAS  PubMed  Google Scholar 

  • Yong VW, Power C, Forsyth P, Edwards DR, 2001, Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci. 2:502–511.

    Article  CAS  PubMed  Google Scholar 

  • Yushchenko M, Weber F, Mader M, Scholl U, Maliszewska M, Tumani H, Felgenhauer K, Beuche W, 2000, Matrix metalloproteinase-9 (MMP-9) in human cerebrospinal fluid (CSF): elevated levels are primarily related to CSF cell count. J Neuroimmunol. 110:244–251.

    Article  CAS  PubMed  Google Scholar 

  • Zang YC, Kozovska MM, Hong J, Li S, Mann S, Killian JM, Rivera VM, Zhang JZ, 1999, Impaired apoptotic deletion of myelin basic protein-reactive T cells in patients with multiple sclerosis. Eur J Immunol. 29:1692–1700.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Research Group for Clinical and Experimental Neuroimmunology, Department of Neurology, Heinrich-Heine-University, Moorenstrasse 5, 40225, Duesseldorf, Germany

    Bernd C. Kieseier & Fabian Bernal

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  1. Bernd C. Kieseier
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  2. Fabian Bernal
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  1. Otto-von-Guericke University, Magdeburg, Germany

    Uwe Lendeckel

  2. University of Leeds, Leeds, UK

    Nigel M. Hooper

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Kieseier, B.C., Bernal, F. (2005). Proteases in CNS Infection and Inflammation. In: Lendeckel, U., Hooper, N.M. (eds) Proteases In The Brain. Proteases In Biology and Disease, vol 3. Springer, Boston, MA. https://doi.org/10.1007/0-387-23101-3_5

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