Conclusions
One-carbon reactions play large roles in the two major pathways for methane formation in nature. Several of the enzymes catalyzing these reactions have novel features, contributing to a larger understanding of biochemistry and microbial biology. The crystal structures for many of these enzymes are known, providing insight into the reaction mechanisms. The entire sequence of the genomes of several CO2-reducing and acetatefermenting methanoarchaea have been published or are nearing completion, an advance that will surely lead to the identification of still more novel proteins and enzymes involved in these pathways.
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Ferry, J.G. (2003). One-Carbon Metabolism in Methanogenic Anaerobes. In: Ljungdahl, L.G., Adams, M.W., Barton, L.L., Ferry, J.G., Johnson, M.K. (eds) Biochemistry and Physiology of Anaerobic Bacteria. Springer, New York, NY. https://doi.org/10.1007/0-387-22731-8_11
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