Skip to main content
  • 506 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

Normal Morphology and Common Leukemias

  • Azar HA: The hematopoietic system. In Trump BF, Jones RT, eds: Diagnostic Electron Microscopy, vol 2. John Wiley and Sons, New York, 1979, 47–161.

    Google Scholar 

  • Behm FG: Morphologic and cytochemical characteristics of childhood lymphoblastic leukemia. Hematol Oncol Clin North Am 4:715–741, 1990.

    CAS  PubMed  Google Scholar 

  • Bennett JM, Catovsky D, Daniel MT, et al: Proposals for the classification of chronic (mature) B and T lymphoid leukaemias. French-American-British (FAB) Cooperative Group. J Clin Pathol 42:567–584, 1989.

    CAS  PubMed  Google Scholar 

  • Bessho F, Hayashi Y, Hayashi Y, et al: Ultrastructural studies of peripheral blood of neonates with Down’s syndrome and transient abnormal myelopoiesis. Am J Clin Pathol 89:627–633, 1988.

    CAS  PubMed  Google Scholar 

  • Bessie M: Living Blood Cells and Their Ultrastructure. Springer-Verlag, Berlin, 1973.

    Google Scholar 

  • Breton-Gorius J, Houssay D: Auer bodies in acute promyelocytic leukemia. Demonstration of their fine structure and peroxidase localization. Lab Invest 28: 135–141, 1973.

    Google Scholar 

  • Brunning RD, McKenna RW: Tumors of the bone marrow. In Rosai J, Sobin LH, eds: Atlas of Tumor Pathology, 3rd series, fasc 9. Armed Forces Institute of Pathology, Washington, DC, 1994.

    Google Scholar 

  • Brunning RD, Parkin JL, McKenna RW: Acute lymphoblastic leukemia. In Polliack A, ed. Human Leukemias: Cytochemical and Ultrastructural Techniques in Diagnosis and Research. Boston, Martinus Nijhoff, 1984, 173–218.

    Google Scholar 

  • Buccheri V, Shetty V, Yoshida N, et al: The role of an antimyeloperoxidase antibody in the diagnosis and classification of acute leukaemia: A comparison with light and electron microscopy cytochemistry. Br J Haematol 80:62–68, 1992.

    CAS  PubMed  Google Scholar 

  • Chan WC, Link S, Mawle A, et al: Heterogeneity of large granular lymphocyte proliferations: Delineation of two major subtypes. Blood 68:1142–1153, 1986.

    CAS  PubMed  Google Scholar 

  • Cowley JC, Hayhoe FGJ: Ultrastructure of Hemic Cells: A Cytologic Atlas of Normal and Leukemic Blood and Bone Marrow. WB Saunders, Philadelphia, 1973.

    Google Scholar 

  • Darbyshire PJ, Lilleyman JS: Granular acute lymphoblastic leukemia of childhood: A morphologic phenomenon. J Clin Pathol 40:251–253, 1987.

    CAS  PubMed  Google Scholar 

  • Dickersin GR: Electron microscopy of leukemias and lymphomas. Clin Lab Med 7(1):199–247, 1987.

    CAS  PubMed  Google Scholar 

  • Dvorak AM, Monahan RA, Dickersin GR: I. Hematology: Differential diagnosis of acute lymphoblastic and acute myeloblastic leukemia. Use of ultrastructural peroxidase cytochemistry and routine electron microscopy technology. Pathol Annu 16:101–137, 1981.

    PubMed  Google Scholar 

  • Eimoto T, Mitsui T, Kikuchi M: Ultrastructure of adult T-cell leukemia/lymphoma. Virchows Arch [Cell Pathol] 38:189–208, 1981.

    CAS  Google Scholar 

  • Fradera J, Velez-Garcia E, White JG: Acute lymphoblastic leukemia with unusual cytoplasmic granulation: A morphologic, cytochemical and ultrastructural study. Blood 68:406–411, 1986.

    CAS  PubMed  Google Scholar 

  • Glick AD: Acute leukemia: Electron microscopic diagnosis. Semin Oncol 3:229–241, 1976.

    CAS  PubMed  Google Scholar 

  • Glick AD, Paniker K, Flexner JM, et al: Acute leukemia of adults. Ultrastructural, cytochemical and histologic observations in 100 cases. Am J Clin Pathol 73:459–470, 1980.

    CAS  PubMed  Google Scholar 

  • Golomb HM, Rowley JD, Vardiman JW, et al: “Microgranular” acute promyelocytic leukemia: A distinctive clinical, ultrastructural and cytogenetic entity. Blood 55:253–259, 1980.

    CAS  PubMed  Google Scholar 

  • Grogan TM, Insalaco SJ, Savage RA, et al: Acute lymphoblastic leukemia with prominent azurophilic granulation and punctate acidic nonspecific esterase and phosphatase activity. Am J Clin Pathol 75:716–722, 1981.

    CAS  PubMed  Google Scholar 

  • Hay CR, Barnett D, James V, et al: Granular common acute lymphoblastic leukemia in adults: A morphologic study. Eur J Haematol 39:299–305, 1987.

    CAS  PubMed  Google Scholar 

  • Kantarjian HM, Diesseroth A, Kurzrock R, et al: Chronic myelogenous leukemia: A concise update. Blood 82: 691–703, 1993.

    CAS  PubMed  Google Scholar 

  • Marie JP, Vernant JP, Dreyfus B, et al: Ultrastructural localization of peroxidases in “undifferentiated” blasts during the blast crisis of chronic granulocytic leukaemia. Br J Haematol 43:549–558, 1979.

    CAS  PubMed  Google Scholar 

  • McKenna RW, Parkin J, Brunning RD: Morphologic and ultrastructural characteristics of T-cell acute lymphoblastic leukemia. Cancer 44:1290–1297, 1979.

    CAS  PubMed  Google Scholar 

  • Melo JV, Hegde U, Parreira A, et al: Splenic B cell lymphoma with circulating villous lymphocytes: Differential diagnosis of B cell leukaemias with large spleens. J Clin Pathol 40:642–651, 1987.

    CAS  PubMed  Google Scholar 

  • Oshimi K: Granular lymphocyte proliferative disorders: Report of 12 cases and review of the literature. Leukemia 2:617–627, 1988.

    CAS  PubMed  Google Scholar 

  • Parkin JL, McKenna RW, Brunning RD: Philadelphia chromosome-positive blastic leukaemia: Ultrastructural and ultracytochemical evidence of basophil and mast cell differentiation. Br J Haematol 52:663–677, 1982.

    CAS  PubMed  Google Scholar 

  • Schmidt U, Mlynek ML, Leder LD: Electron-microscopic characterization of mixed granulated (hybridoid) leucocytes of chronic myeloid leukaemia. Br J Haematol 68:175–180, 1988.

    CAS  PubMed  Google Scholar 

  • Shetty V, Chitale A, Matutes E, et al: Immunological and ultrastructural studies in acute biphenotypic leukaemia. J Clin Pathol 46:903–907, 1993.

    CAS  PubMed  Google Scholar 

  • Stasi R, Del Poeta G, Venditti A, et al: Lineage identification of acute leukemias: Relevance of immunologic and ultrastructural techniques. Hematol Pathol 9: 79–94, 1995.

    CAS  PubMed  Google Scholar 

  • Stein P, Peiper S, Butler D, et al: Granular acute lymphoblastic leukemia. Am J Clin Pathol 79:426–430, 1983.

    CAS  PubMed  Google Scholar 

  • Takemori N, Hirai K, Onodera R, et al: Parallel tubular granules in human immature neutrophils-An electron microscopic study. Leuk Lymphoma 15:177–186, 1994.

    CAS  PubMed  Google Scholar 

  • Ullyot JL, Bainton DF: Azurophil and specific granules of blood neutrophils in chronic myelogenous leukemia: An ultrastructural and cytochemical analysis. Blood 44:469–482, 1974.

    CAS  PubMed  Google Scholar 

  • Yanagihara ET, Naeim F, Gale RP, et al: Acute lymphoblastic leukemia with giant intracytoplasmic inclusions. Am J Clin Pathol 74:345–349, 1980.

    CAS  PubMed  Google Scholar 

  • Zucker-Franklin D, Greaves MF, Grossi CE, et al: Atlas of Blood Cells, Function and Pathology, 2nd ed, vols 1 and 2. Lea and Febiger, Philadelphia, 1988.

    Google Scholar 

Megakaryocytic Leukemia

  • Bain B, Catovsky D, O’Brien M, et al: Megakaryoblastic transformation of chronic granulocytic leukaemia: An electron microscopy and cytochemical study. J Clin Pathol 30:235–242, 1977.

    CAS  PubMed  Google Scholar 

  • Bennett JM, Catovsky D, Daniel MT, et al: Criteria for the diagnosis of acute leukemia of megakaryocytic lineage (M7): A report of the French-American-British Cooperative Group. Ann Intern Med 103:460–462, 1985.

    CAS  PubMed  Google Scholar 

  • Breton-Gorius J, Reyes F, Duhamel G, et al: Megakaryoblastic acute leukemia: Identification by the ultrastructural demonstration of platelet peroxidase. Blood 51:45–60, 1978.

    CAS  PubMed  Google Scholar 

  • Breton-Gorius J, Reyes F, Vernant JP: The blast crisis of chronic granulocytic leukaemia: Megakaryoblastic nature of cells are revealed by the presence of platelet-peroxidase-cytochemical ultrastructural study. Br J Haematol 39:295–303, 1978.

    CAS  PubMed  Google Scholar 

  • Brunning RD, McKenna RW: Tumors of the bone marrow. In Rosai J, Sobin LH, eds: Atlas of Tumor Pathology, 3rd series, fasc 9. Armed Forces Institute of Pathology, Washington, DC, 1994.

    Google Scholar 

  • Innes DJ, Mills SE, Walker GK: Megakaryocytic leukemia: Identification utilizing anti-factor VIII immunoperoxidase. Am J Clin Pathol 77:107–110, 1982.

    PubMed  Google Scholar 

  • Jacobs P, LeRoux I, Jacobs L: Megakaryoblastic transformation in myeloproliferative disorders. Cancer 54: 297–302, 1984.

    CAS  PubMed  Google Scholar 

  • Koike T: Megakaryoblastic leukemia: The characterization and identification of megakaryoblasts. Blood 64:683–692, 1984.

    CAS  PubMed  Google Scholar 

  • Mirchandani I, Palutke M: Acute megakaryoblastic leukemia. Cancer 50:2866–2872, 1983.

    Google Scholar 

  • Williams W, Weiss GB: Megakaryoblastic transformation of chronic myelogenous leukemia. Cancer 49: 921–926, 1982.

    CAS  PubMed  Google Scholar 

Hairy-Cell Leukemia

  • Bartl R, Frisch B, Hill W, et al: Bone marrow histology in hairy-cell leukemia: Identification of subtypes and their prognostic significance. Am J Clin Pathol 79: 531–545, 1983.

    CAS  PubMed  Google Scholar 

  • Braylan RC, Jaffe ES, Triche TJ, et al: Structural and functional properties of the “hairy” cells of leukemic reticuloendotheliosis. Cancer 41:210–227, 1978.

    CAS  PubMed  Google Scholar 

  • Brunning RD, McKenna RW: Tumors of the bone marrow. In Rosai J, Sobin LH, eds: Atlas of Tumor Pathology, 3rd series, fasc 9. Armed Forces Institute of Pathology, Washington, DC, 1994.

    Google Scholar 

  • Burke JS, MacKay B, Rappaport H: Hairy cell leukemia (leukemic reticuloendotheliosis). II. Ultrastructure of the spleen. Cancer 37:2267–2274, 1976.

    CAS  PubMed  Google Scholar 

  • Catovsky D, Petitt JE, Galton DAG, et al: Leukaemic reticuloendotheliosis (“hairy” cell leukaemia): A distinct clinicopathologic entity. Br J Haematol 26:9–27, 1974.

    CAS  PubMed  Google Scholar 

  • Chang KL, Stroup R, Weiss LM: Hairy cell leukemia. Current status. Anat Pathol 97:719–738, 1992.

    CAS  Google Scholar 

  • Daniel M, Flandrin G: Fine structure of abnormal cells in hairy cell (tricholeukocytic) leukemia, with special reference to their in vitro phagocytic capacity. Lab Invest (Paris) 30:1–8, 1974.

    CAS  Google Scholar 

  • Zucker-Franklin D: Virus-like particles in the lymphocyte of a patient with chronic lymphocytic leukemia. Blood 21:509–512, 1963.

    CAS  PubMed  Google Scholar 

Download references

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

(2000). Leukemias. In: Dickersin, G.R. (eds) Diagnostic Electron Microscopy. Springer, New York, NY. https://doi.org/10.1007/0-387-21852-1_5

Download citation

  • DOI: https://doi.org/10.1007/0-387-21852-1_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-98388-2

  • Online ISBN: 978-0-387-21852-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics