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Cancer Precursors

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References

  1. Compton C. Incipient neoplasia of the large intestine. In: Henson DE, Albores-Saavedra J (eds) The pathology of incipient neoplasia. New York: Oxford University Press, 2000, pp. 174–206.

    Google Scholar 

  2. Peipins LA, Sandler RS. Epidemiology of colorectal adenomas. Epidemiol Rev 1994; 16:273–97.

    PubMed  CAS  Google Scholar 

  3. Eide TJ. Remnants of adenomas in colorectal carcinomas. Cancer 1983; 51:1866–72.

    PubMed  CAS  Google Scholar 

  4. Konishi F, Morson BC. Pathology of colorectal adenomas: a colonoscopic survey. J Clin Pathol 1982; 35:830–41.

    PubMed  CAS  Google Scholar 

  5. Matek W, Hermanek P, Demling L. Is the adenoma-carcinoma sequence contradicted by the differing location of colorectal adenomas and carcinomas? Endoscopy 1986; 18:17–9.

    CAS  Google Scholar 

  6. Stryker SJ, Wolff BG, Culp CE, et al. Natural history of untreated colonic polyps. Gastroenterology 1987; 93:1009–13.

    PubMed  CAS  Google Scholar 

  7. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87:159–70.

    Article  PubMed  CAS  Google Scholar 

  8. Potter JD. Colorectal cancer: molecules and populations. J Natl Cancer Inst 1999; 91:916–32.

    Article  PubMed  CAS  Google Scholar 

  9. Powell SM, Zilz N, Beazer-Barclay Y, et al. APC mutations occur early during colorectal tumorigenesis. Nature 1992; 359:235–7.

    Article  PubMed  CAS  Google Scholar 

  10. Boland CR, Sato J, Appelman HD, et al. Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression. Nat Med 1995; 1:902–9.

    Article  PubMed  CAS  Google Scholar 

  11. Ahuja N, Li Q, Mohan AL, et al. Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res 1998; 58:5489–94.

    PubMed  CAS  Google Scholar 

  12. Grady WM, Rajput A, Myeroff L, et al. Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas. Cancer Res 1998; 58: 3101–4.

    PubMed  CAS  Google Scholar 

  13. Samowitz WS, Slattery ML. Microsatellite instability in colorectal adenomas. Gastroenterology 1997; 112:1515–19.

    Article  PubMed  CAS  Google Scholar 

  14. Young J, Leggett B, Gustafson C, et al. Genomic instability occurs in colorectal carcinomas but not in adenomas. Hum Mutat 1993; 2:351–4.

    Article  PubMed  CAS  Google Scholar 

  15. Tierney RP, Ballantyne GH, Modlin IM. The adenoma to carcinoma sequence. Surg Gynecol Obstet 1990; 171:81–94.

    PubMed  CAS  Google Scholar 

  16. Eide TJ. Risk of colorectal cancer in adenoma-bearing individuals within a defined population. Int J Cancer 1986; 38:173–6.

    PubMed  CAS  Google Scholar 

  17. Knoernschild H. Growth rate and malignant potential of colonic polyps: early results. Surg Forum 1963; 14:137.

    PubMed  CAS  Google Scholar 

  18. Welin S, Youker J, Spratt J. The rates and patterns of growth of 375 tumors of the large intestine and rectum observed serially by double contrast enema study (Malmo technique). Am J Roentgenol Radium Ther Nucl Med 1963; 90:673–87.

    PubMed  CAS  Google Scholar 

  19. Nicholls RJ, Springall RG, Gallagher P. Regression of rectal adenomas after colectomy and ileorectal anastomosis for familial adenomatous polyposis. Br Med J Clin Res Ed 1988; 296:1707–8.

    PubMed  CAS  Google Scholar 

  20. Hofstad B, Vatn M, Larsen S, et al. Growth of colorectal polyps: recovery and evaluation of unresected polyps of less than 10mm, 1 year after detection. Scand J Gastroenterol 1994; 29:640–5.

    PubMed  CAS  Google Scholar 

  21. Cole JW, Holden WD, Cleveland MD. Post-colectomy regression of adenomatous polyps of the rectum. AMA Arch Surg 1959; 41:385–92.

    Google Scholar 

  22. Hoff G, Foerster A, Vatn MH, et al. Epidemiology of polyps in the rectum and colon. Recovery and evaluation of unresected polyps 2 years after detection. Scand J Gastroenterol 1986; 21:853–62.

    PubMed  CAS  Google Scholar 

  23. Bedenne L, Faivre J, Boutron MC, et al. Adenoma-carcinoma sequence or “de novo” carcinogenesis? A study of adenomatous remnants in a population-based series of large bowel cancers. Cancer 1992; 69:883–8.

    PubMed  CAS  Google Scholar 

  24. Murakami R, Tsukuma H, Kanamori S, et al. Natural history of colorectal polyps and the effect of polypectomy on occurrence of subsequent cancer. Int J Cancer 1990; 46:159–64.

    PubMed  CAS  Google Scholar 

  25. Selby JV, Friedman GD, Quesenberry CP Jr, et al. A case-control study of screening sigmoidoscopy and mortality from colorectal cancer. N Engl J Med 1992; 326:653–7.

    PubMed  CAS  Google Scholar 

  26. Muller AD, Sonnenberg A. Prevention of colorectal cancer by flexible endoscopy and polypectomy. A case-control study of 32,702 veterans. Ann Int Med 1995; 123:904–10.

    PubMed  CAS  Google Scholar 

  27. Newcomb PA, Norfleet RG, Storer BE, et al. Screening sigmoidoscopy and colorectal cancer mortality. J Natl Cancer Inst 1992; 84:1572–5.

    PubMed  CAS  Google Scholar 

  28. Mandel JS, Church TR, Bond JH, et al. The effect of fecal occult-blood screening on the incidence of colorectal cancer. N Engl J Med 1603; 343:1603–7.

    Google Scholar 

  29. Ahlquist DA. Aggressive polyps in hereditary nonpolyposis colorectal cancer: targets for screening. Gastroenterology 1995; 108:1590–2.

    Article  PubMed  CAS  Google Scholar 

  30. Jacoby RF, Marshall DJ, Kailas S, et al. Genetic instability associated with adenoma to carcinoma progression in hereditary nonpolyposis colon cancer. Gastroenterology 1995; 109:73–82.

    Article  PubMed  CAS  Google Scholar 

  31. Jarvinen HJ, Aarnio M, Mustonen H, et al. Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer. Gastroenterology 2000; 118: 829–34.

    Article  PubMed  CAS  Google Scholar 

  32. Morson BC. The polyp story. Postgrad Med J 1984; 60:820–4.

    PubMed  CAS  Google Scholar 

  33. Owen DA. Flat adenoma, flat carcinoma, and de novo carcinoma of the colon. Cancer 1996; 77:3–6.

    Article  PubMed  CAS  Google Scholar 

  34. Muto T, Kamiya J, Sawada T, et al. Small “flat adenoma” of the large bowel with special reference to its clinicopathologic features. Dis Colon Rectum 1985; 28:847–51.

    PubMed  CAS  Google Scholar 

  35. Wolber RA, Owen DA. Flat adenomas of the colon. Hum Pathol 1991; 22:70–4.

    PubMed  CAS  Google Scholar 

  36. Lanspa SJ, Rouse J, Smyrk T, et al. Epidemiologic characteristics of the flat adenoma of Muto. A prospective study. Dis Colon Rectum 1992; 35:543–6.

    Article  PubMed  CAS  Google Scholar 

  37. Fujimori T, Satonaka K, Yamamura-Idei Y, et al. Non-involvement of ras mutations in flat colorectal adenomas and carcinomas. Int J Cancer 1994; 57:51–5.

    PubMed  CAS  Google Scholar 

  38. Jaramillo E, Watanabe M, Slezak P, et al. Flat neoplastic lesions of the colon and rectum detected by high-resolution video endoscopy and chromoscopy. Gastrointest Endosc 1995; 42:114–22.

    Article  PubMed  CAS  Google Scholar 

  39. Lynch HT, Smyrk TC, Watson P, et al. Hereditary flat adenoma syndrome: a variant of familial adenomatous polyposis? Dis Colon Rectum 1992; 35:411–21.

    Article  PubMed  CAS  Google Scholar 

  40. Kubota O, Kino I. Minute adenomas of the depressed type in familial adenomatous polyposis of the colon. A pathway to ordinary polypoid adenomas. Cancer 1993; 72:1159–64.

    PubMed  CAS  Google Scholar 

  41. Yamagata S, Muto T, Uchida Y, et al. Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas. Jap J Cancer Res 1994; 85:147–51.

    CAS  Google Scholar 

  42. Shimoda T, Ikegami M, Fujisaki J, et al. Early colorectal carcinoma with special reference to its development de novo. Cancer 1989; 64:1138–46.

    PubMed  CAS  Google Scholar 

  43. Kuramoto S, Oohara T. How do colorectal cancers develop? Cancer 1995; 75(6 Suppl): 1534–8.

    PubMed  CAS  Google Scholar 

  44. Driman DK, Riddell RH. Flat adenomas and flat carcinomas: do you see what I see? [editorial]. Gastrointest Endosc 1994; 40:106–9.

    PubMed  CAS  Google Scholar 

  45. Minamoto T, Sawaguchi K, Ohta T, et al. Superficial-type adenomas and adenocarcinomas of the colon and rectum: a comparative morphological study. Gastroenterology 1994; 106:1436–43.

    PubMed  CAS  Google Scholar 

  46. Neugut AI, Jacobson JS, DeVivo I. Epidemiology of colorectal adenomatous polyps. Cancer Epidemiol Biomarkers Prev 1993; 2: 159–76.

    PubMed  CAS  Google Scholar 

  47. Shinya H, Wolff WI. Morphology, anatomic distribution and cancer potential of colonic polyps. Ann Surg 1979; 190:679–83.

    PubMed  CAS  Google Scholar 

  48. Lieberman DA, Smith FW. Screening for colon malignancy with colonoscopy. Am J Gastroenterol 1991; 86:946–51.

    PubMed  CAS  Google Scholar 

  49. Levin TR, Palitz A, Grossman S, et al. Predicting advanced proximal colonic neoplasia with screening sigmoidoscopy. JAMA 1999; 281: 1611–7.

    Article  PubMed  CAS  Google Scholar 

  50. Schoen RE, Corle D, Cranston L, et al. Is colonoscopy needed for the nonadvanced adenoma found on sigmoidoscopy? The Polyp Prevention Trial. Gastroenterology 1998; 115: 533–41.

    Article  PubMed  CAS  Google Scholar 

  51. Wallace MB, Kemp JA, Trnka YM, et al. Is colonoscopy indicated for small adenomas found by screening flexible sigmoidoscopy? Ann Int Med 1998; 129:273–8.

    PubMed  CAS  Google Scholar 

  52. Zarchy TM, Ershoff D. Do characteristics of adenomas on flexible sigmoidoscopy predict advanced lesions on baseline colonoscopy? Gastroenterology 1994; 106:1501–4.

    PubMed  CAS  Google Scholar 

  53. Atkin WS, Morson BC, Cuzick J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med 1992; 326:658–62.

    PubMed  CAS  Google Scholar 

  54. Gatteschi B, Costantini M, Bruzzi P, et al. Univariate and multivariate analyses of the relationship between adenocarcinoma and solitary and multiple adenomas in colorectal adenoma patients. Int J Cancer 1991; 49:509–12.

    PubMed  CAS  Google Scholar 

  55. Muto T, Bussey HJ, Morson BC. The evolution of cancer of the colon and rectum. Cancer 1975; 36:2251–70.

    PubMed  CAS  Google Scholar 

  56. Simons BD, Morrison AS, Lev R, et al. Relationship of polyps to cancer of the large intestine. J Natl Cancer Inst 1992; 84:962–6.

    PubMed  CAS  Google Scholar 

  57. Lotfi AM, Spencer RJ, Ilstrup DM, et al. Colorectal polyps and the risk of subsequent carcinoma. Mayo Clinic Proc 1986; 61:337–43.

    CAS  Google Scholar 

  58. Yang G, Zheng W, Sun QR, et al. Pathologic features of initial adenomas as predictors for metachronous adenomas of the rectum. J Natl Cancer Inst 1998; 90:1661–5.

    Article  PubMed  CAS  Google Scholar 

  59. Winawer SJ, Zauber AG, O’Brien MJ, et al. Randomized comparison of surveillance intervals after colonoscopic removal of newly diagnosed adenomatous polyps. The National Polyp Study Workgroup. N Engl J Med 1993; 328:901–6.

    PubMed  CAS  Google Scholar 

  60. Grossman S, Milos ML, Tekawa IS, et al. Colonoscopic screening of persons with suspected risk factors for colon cancer: II. Past history of colorectal neoplasms. Gastroenterology 1989; 96(2 Pt 1):299–306.

    PubMed  CAS  Google Scholar 

  61. van Stolk RU, Beck GJ, Baron JA, et al. Adenoma characteristics at first colonoscopy as predictors of adenoma recurrence and characteristics at follow-up. The Polyp Prevention Study Group. Gastroenterology 1998; 115:13–8.

    PubMed  Google Scholar 

  62. Aubert H, Treille C, Faure H, et al. [Interest for colonic cancer prevention of the follow-up of patients after endoscopic resection of colorectal polyps: 123 cases (author’s transl)]. Gastroenterol Clin Biol 1982; 6:183–7.

    PubMed  CAS  Google Scholar 

  63. Potter JD. Nutrition and colorectal cancer. Cancer Causes & Control 1996; 7:127–46.

    CAS  Google Scholar 

  64. World Cancer Research Fund, American Institute for Cancer Research. Food, nutrition and the prevention of cancer: a global perspective. Washington, DC: American Institute for Cancer Research, 1997, passim.

    Google Scholar 

  65. Benito E, Cabeza E, Moreno V, et al. Diet and colorectal adenomas: a case-control study in Majorca. Int J Cancer 1993; 55:213–9.

    PubMed  CAS  Google Scholar 

  66. Witte JS, Longnecker MP, Bird CL, et al. Relation of vegetable, fruit, and grain consumption to colorectal adenomatous polyps. Am J Epidemiol 1996; 144:1015–25.

    PubMed  CAS  Google Scholar 

  67. Kato I, Tominaga S, Matsuura A, et al. A comparative case-control study of colorectal cancer and adenoma. Jap J Cancer Res 1990; 81:1101–8.

    CAS  Google Scholar 

  68. Sandler RS, Lyles CM, Peipins LA, et al. Diet and risk of colorectal adenomas: macronutrients, cholesterol, and fiber. J Natl Cancer Inst 1993; 85:884–91.

    PubMed  CAS  Google Scholar 

  69. Platz EA, Giovannucci E, Rimm EB, et al. Dietary fiber and distal colorectal adenoma in men. Cancer Epidemiol Biomarkers Prev 1997; 6:661–70.

    PubMed  CAS  Google Scholar 

  70. Little J, Logan RF, Hawtin PG, et al. Colorectal adenomas and diet: a case-control study of subjects participating in the Nottingham faecal occult blood screening programme. Br J Cancer 1993; 67:177–84.

    PubMed  CAS  Google Scholar 

  71. Hoff G, Moen IE, Trygg K, et al. Colorectal adenomas and food. A prospective study of change in volume and total mass of adenomas in man. Scand J Gastroenterol 1988; 23:1253–8.

    PubMed  CAS  Google Scholar 

  72. Fuchs CS, Giovannucci EL, Colditz GA, et al. Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med 1999; 340:169–76.

    Article  PubMed  CAS  Google Scholar 

  73. Martinez ME, McPherson RS, Annegers JF, et al. Association of diet and colorectal adenomatous polyps: dietary fiber, calcium, and total fat. Epidemiology 1996; 7:264–8.

    PubMed  CAS  Google Scholar 

  74. Macquart-Moulin G, Riboli E, Cornee J, et al. Colorectal polyps and diet: a case-control study in Marseilles. Int J Cancer 1987; 40:179–88.

    PubMed  CAS  Google Scholar 

  75. Haile RW, Witte JS, Longnecker MP, et al. A sigmoidoscopy-based case-control study of polyps: macronutrients, fiber and meat consumption. Int J Cancer 1997; 73:497–502.

    Article  PubMed  CAS  Google Scholar 

  76. Giovannucci E, Stampfer MJ, Colditz G, et al. Relationship of diet to risk of colorectal adenoma in men. J Natl Cancer Inst 1992; 84:91–8.

    PubMed  CAS  Google Scholar 

  77. Neugut AI, Garbowski GC, Lee WC, et al. Dietary risk factors for the incidence and recurrence of colorectal adenomatous polyps. A case-control study. Ann Int Med 1993; 118:91–5.

    PubMed  CAS  Google Scholar 

  78. Olsen J, Kronborg O, Lynggaard J, et al. Dietary risk factors for cancer and adenomas of the large intestine. A case-control study within a screening trial in Denmark. Eur J Cancer 1994; 30A:53–60.

    PubMed  CAS  Google Scholar 

  79. Sinha R, Chow WH, Kulldorff M, et al. Well-done, grilled red meat increases the risk of colorectal adenomas. Cancer Res 1999; 59:4320–4.

    PubMed  CAS  Google Scholar 

  80. Probst-Hensch NM, Sinha R, Longnecker MP, et al. Meat preparation and colorectal adenomas in a large sigmoidoscopy-based case-control study in California (United States). Cancer Causes Control 1997; 8:175–83.

    Article  PubMed  CAS  Google Scholar 

  81. Giovannucci E, Stampfer MJ, Colditz GA, et al. Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 1993; 85:875–84.

    PubMed  CAS  Google Scholar 

  82. Bird CL, Swendseid ME, Witte JS, et al. Red cell and plasma folate, folate consumption, and the risk of colorectal adenomatous polyps. Cancer Epidemiol Biomarkers Prev 1995; 4: 709–14.

    PubMed  CAS  Google Scholar 

  83. Baron JA, Sandler RS, Haile RW, et al. Folate intake, alcohol consumption, cigarette smoking, and risk of colorectal adenomas. J Natl Cancer Inst 1998; 90:57–62.

    PubMed  CAS  Google Scholar 

  84. Bergsma-Kadijk JA, van’t Veer P, Kampman E, et al. Calcium does not protect against colorectal neoplasia. Epidemiology 1996; 7:590–7.

    PubMed  CAS  Google Scholar 

  85. Martinez ME, Willett WC. Calcium, vitamin D, and colorectal cancer: a review of the epidemiologic evidence. Cancer Epidemiol Biomarkers Prev 1998; 7:163–8.

    PubMed  CAS  Google Scholar 

  86. Enger SM, Longnecker MP, Chen MJ, et al. Dietary intake of specific carotenoids and vitamins A, C, and E, and prevalence of colorectal adenomas. Cancer Epidemiol Biomarkers Prev 1996; 5:147–53.

    PubMed  CAS  Google Scholar 

  87. Shikany JM, Witte JS, Henning SM, et al. Plasma carotenoids and the prevalence of adenomatous polyps of the distal colon and rectum. Am J Epidemiol 1997; 145:552–7.

    PubMed  CAS  Google Scholar 

  88. Tseng M, Murray SC, Kupper LL, et al. Micronutrients and the risk of colorectal adenomas [published erratum in Am J Epidemiol 1997; 146:788]. Am J Epidemiol 1996; 144:1005–14.

    PubMed  CAS  Google Scholar 

  89. Bird CL, Ingles SA, Frankl HD, et al. Serum lipids and adenomas of the left colon and rectum. Cancer Epidemiol Biomarkers Prev 1996; 5:607–12.

    PubMed  CAS  Google Scholar 

  90. Tseng M, Sandler RS, Greenberg ER, et al. Dietary iron and recurrence of colorectal adenomas [published erratum appears in Cancer Epidemiol Biomarkers Prev 1988; 7:556]. Cancer Epidemiol Biomarkers Prev 1997; 6:1029–32.

    PubMed  CAS  Google Scholar 

  91. Nelson RL, Davis FG, Sutter E, et al. Body iron stores and risk of colonic neoplasia. J Natl Cancer Inst 1994; 86:455–60.

    PubMed  CAS  Google Scholar 

  92. Clark LC, Hixson LJ, Combs GF Jr, et al. Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps. Cancer Epidemiol Biomarkers Prev 1993; 2:41–6.

    PubMed  CAS  Google Scholar 

  93. Dworkin BM, Rosenthal WS, Mittelman A, et al. Selenium status and the polyp-cancer sequence: a colonoscopically controlled study. Am J Gastroenterol 1988; 83:748–51.

    PubMed  CAS  Google Scholar 

  94. Nelson RL, Davis FG, Sutter E, et al. Serum selenium and colonic neoplastic risk. Dis Colon Rectum 1995; 38:1306–10.

    PubMed  CAS  Google Scholar 

  95. Russo MW, Murray SC, Wurzelmann JI, et al. Plasma selenium levels and the risk of colorectal adenomas. Nutr Cancer 1997; 28:125–9.

    PubMed  CAS  Google Scholar 

  96. Giovannucci E. Meta-analysis of coffee consumption and risk of colorectal cancer. Am J Epidemiol 1998; 147:1043–52.

    PubMed  CAS  Google Scholar 

  97. Cope GF, Wyatt JI, Pinder IF, et al. Alcohol consumption in patients with colorectal adenomatous polyps. Gut 1991; 32:70–2.

    PubMed  CAS  Google Scholar 

  98. Olsen J, Kronborg O. Coffee, tobacco and alcohol as risk factors for cancer and adenoma of the large intestine. Int J Epidemiol 1993; 22:398–402.

    PubMed  CAS  Google Scholar 

  99. Kono S, Shinchi K, Ikeda N, et al. Physical activity, dietary habits and adenomatous polyps of the sigmoid colon: a study of self-defense officials in Japan. J Clin Epidemiol 1991; 44:1255–61.

    Article  PubMed  CAS  Google Scholar 

  100. Kono S, Imanishi K, Shinchi K, et al. Relationship of diet to small and large adenomas of the sigmoid colon. Jap J Cancer Res 1993; 84:13–9.

    CAS  Google Scholar 

  101. Baron JA, Greenberg ER, Haile R, et al. Coffee and tea and the risk of recurrent colorectal adenomas. Cancer Epidemiol Biomarkers Prev 1997; 6:7–10.

    PubMed  CAS  Google Scholar 

  102. Lee WC, Neugut AI, Garbowski GC, et al. Cigarettes, alcohol, coffee, and caffeine as risk factors for colorectal adenomatous polyps. Ann Epidemiol 1993; 3:239–44.

    PubMed  CAS  Google Scholar 

  103. Sandler RS, Pritchard ML, Bangdiwala SI. Physical activity and the risk of colorectal adenomas. Epidemiology 1995; 6:602–6.

    PubMed  CAS  Google Scholar 

  104. Kono S, Handa K, Hayabuchi H, et al. Obesity, weight gain and risk of colon adenomas in Japanese men. Jap J Cancer Res 1999; 90:805–11.

    CAS  Google Scholar 

  105. Giovannucci E, Ascherio A, Rimm EB, et al. Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med 1995; 122:327–34.

    PubMed  CAS  Google Scholar 

  106. Giovannucci E, Colditz GA, Stampfer MJ, et al. Physical activity, obesity, and risk of colorectal adenoma in women (United States). Cancer Causes Control 1996; 7:253–63.

    Article  PubMed  CAS  Google Scholar 

  107. Enger SM, Longnecker MP, Lee ER, et al. Recent and past physical activity and prevalence of colorectal adenomas. Br J Cancer 1997; 75:740–5.

    PubMed  CAS  Google Scholar 

  108. Davidow AL, Neugut AI, Jacobson JS, et al. Recurrent adenomatous polyps and body mass index. Cancer Epidemiol Biomarkers Prev 1996; 5:313–5.

    PubMed  CAS  Google Scholar 

  109. Neugut AI, Lee WC, Garbowski GC, et al. Obesity and colorectal adenomatous polyps. J Natl Cancer Inst 1991; 83:359–61.

    PubMed  CAS  Google Scholar 

  110. Bird CL, Frankl HD, Lee ER, et al. Obesity, weight gain, large weight changes, and adenomatous polyps of the left colon and rectum. Am J Epidemiol 1998; 147:670–80.

    PubMed  CAS  Google Scholar 

  111. Mannes GA, Maier A, Thieme C, et al. Relation between the frequency of colorectal adenoma and the serum cholesterol level. N Engl J Med 1986; 315:1634–8.

    PubMed  CAS  Google Scholar 

  112. Kono S, Ikeda N, Yanai F, et al. Serum lipids and colorectal adenoma among male self-defence officials in northern Kyushu, Japan. Int J Epidemiol 1990; 19:274–8.

    PubMed  CAS  Google Scholar 

  113. Bayerdorffer E, Mannes GA, Richter WO, et al. Decreased high-density lipoprotein cholesterol and increased low-density cholesterol levels in patients with colorectal adenomas. Ann Intern Med 1993; 118:481–7.

    PubMed  CAS  Google Scholar 

  114. Peipins LA, Newman B, Sandler RS. Reproductive history, use of exogenous hormones, and risk of colorectal adenomas. Cancer Epidemiol Biomarkers Prev 1997; 6:671–5.

    PubMed  CAS  Google Scholar 

  115. Chen MJ, Longnecker MP, Morgenstern H, et al. Recent use of hormone replacement therapy and the prevalence of colorectal adenomas. Cancer Epidemiol Biomarkers Prev 1998; 7:227–30.

    PubMed  CAS  Google Scholar 

  116. Grodstein F, Newcomb PA, Stampfer MJ. Postmenopausal hormone therapy and the risk of colorectal cancer: a review and meta-analysis. Am J Med 1999; 106:574–82.

    Article  PubMed  CAS  Google Scholar 

  117. Platz EA, Martinez ME, Grodstein F, et al. Parity and other reproductive factors and risk of adenomatous polyps of the distal colorectum (United States). Cancer Causes Control 1997; 8:894–903.

    Article  PubMed  CAS  Google Scholar 

  118. Potter JD, Bostick RM, Grandits GA, et al. Hormone replacement therapy is associated with lower risk of adenomatous polyps of the large bowel: the Minnesota Cancer Prevention Research Unit Case-Control Study. Cancer Epidemiol Biomarkers Prev 1996; 5:779–84.

    PubMed  CAS  Google Scholar 

  119. Garcia Rodriguez LA, Huerta-Alvarez C. Reduced incidence of colorectal adenoma among long-term users of nonsteroidal antiin-flammatory drugs: a pooled analysis of published studies and a new population-based study. Epidemiology 2000; 11:376–81.

    PubMed  CAS  Google Scholar 

  120. Giovannucci E, Martinez ME. Tobacco, colorectal cancer, and adenomas: a review of the evidence. J Natl Cancer Inst 1996; 88:1717–30.

    PubMed  CAS  Google Scholar 

  121. Longnecker MP, Chen MJ, Probst-Hensch NM, et al. Alcohol and smoking in relation to the prevalence of adenomatous colorectal polyps detected at sigmoidoscopy. Epidemiology 1996; 7:275–80.

    PubMed  CAS  Google Scholar 

  122. Nagata C, Shimizu H, Kametani M, et al. Cigarette smoking, alcohol use, and colorectal adenoma in Japanese men and women. Dis Colon Rectum 1999; 42:337–42.

    Article  PubMed  CAS  Google Scholar 

  123. Breuer-Katschinski B, Nemes K, Marr A, et al. Alcohol and cigarette smoking and the risk of colorectal adenomas. Digest Dis Sci 2000; 45:487–93.

    Article  PubMed  CAS  Google Scholar 

  124. Kikendall JW, Bowen PE, Burgess MB, et al. Cigarettes and alcohol as independent risk factors for colonic adenomas. Gastroenterology 1989; 97:660–4.

    PubMed  CAS  Google Scholar 

  125. Kono S, Ikeda N, Yanai F, et al. Alcoholic beverages and adenomatous polyps of the sigmoid colon: a study of male self-defence officials in Japan. Int J Epidemiol 1990; 19:848–52.

    PubMed  CAS  Google Scholar 

  126. Martinez ME, McPherson RS, Annegers JF, et al. Cigarette smoking and alcohol consumption as risk factors for colorectal adenomatous polyps. J Natl Cancer Inst 1995; 87:274–9.

    PubMed  CAS  Google Scholar 

  127. Boutron-Ruault MC, Senesse P, Faivre J, et al. Folate and alcohol intakes: related or independent roles in the adenoma-carcinoma sequence? Nutr Cancer 1996; 26:337–46.

    PubMed  CAS  Google Scholar 

  128. Honjo S, Kono S, Shinchi K, et al. The relation of smoking, alcohol use and obesity to risk of sigmoid colon and rectal adenomas. Jap J Cancer Res 1995; 86:1019–26.

    CAS  Google Scholar 

  129. Todoroki I, Kono S, Shinchi K, et al. Relationship of cigarette smoking, alcohol use, and dietary habits with sigmoid colon adenomas. Ann Epidemiol 1995; 5:478–83.

    Article  PubMed  CAS  Google Scholar 

  130. Sandler RS, Lyles CM, McAuliffe C, et al. Cigarette smoking, alcohol, and the risk of colorectal adenomas. Gastroenterology 1993; 104: 1445–51.

    PubMed  CAS  Google Scholar 

  131. Riboli E, Cornee J, Macquart-Moulin G, et al. Cancer and polyps of the colorectum and lifetime consumption of beer and other alcoholic beverages. Am J Epidemiol 1991; 134:157–66.

    PubMed  CAS  Google Scholar 

  132. Jacobson JS, Neugut AI, Murray T, et al. Cigarette smoking and other behavioral risk factors for recurrence of colorectal adenomatous polyps (New York City, NY, USA). Cancer Causes Control 1994; 5:215–20.

    Article  PubMed  CAS  Google Scholar 

  133. Lubin F, Rozen P, Arieli B, et al. Nutritional and lifestyle habits and water-fiber interaction in colorectal adenoma etiology. Cancer Epidemiol Biomarkers Prev 1997; 6:79–85.

    PubMed  CAS  Google Scholar 

  134. Burt RW, Bishop DT, Cannon LA, et al. Dominant inheritance of adenomatous colonic polyps and colorectal cancer. N Engl J Med 1985; 312:1540–4.

    PubMed  CAS  Google Scholar 

  135. Cannon-Albright LA, Skolnick MH, Bishop DT, et al. Common inheritance of susceptibility to colonic adenomatous polyps and associated colorectal cancers. N Engl J Med 1988; 319:533–7.

    PubMed  CAS  Google Scholar 

  136. Nakama H, Zhang B, Fukazawa K, et al. Family history of colorectal adenomatous polyps as a risk factor for colorectal cancer. Eur J Cancer 2000; 36:2111–4.

    PubMed  CAS  Google Scholar 

  137. Demers RY, Neale AV, Demers P, et al. Serum cholesterol and colorectal polyps. J Clin Epidemiol 1988; 41:9–13.

    Article  PubMed  CAS  Google Scholar 

  138. Kune GA, Kune S, Read A, et al. Colorectal polyps, diet, alcohol, and family history of colorectal cancer: a case-control study. Nutr Cancer 1991; 16:25–30.

    PubMed  CAS  Google Scholar 

  139. Brockton N, Little J, Sharp L, et al. N-acetyl-transferase polymorphisms and colorectal cancer: a HuGE review. Am J Epidemiol 2000; 151:846–61.

    PubMed  CAS  Google Scholar 

  140. Roberts-Thomson IC, Ryan P, Khoo KK, et al. Diet, acetylator phenotype, and risk of colorectal neoplasia. Lancet 1996; 347:1372–4.

    PubMed  CAS  Google Scholar 

  141. Cotton SC, Sharp L, Little J, et al. Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review. Am J Epidemiol 2000; 151:7–32.

    PubMed  CAS  Google Scholar 

  142. Inoue H, Kiyohara C, Marugame T, et al. Cigarette smoking, CYP1A1 MspI and GSTM1 genotypes, and colorectal adenomas. Cancer Res 2000; 60:3749–52.

    PubMed  CAS  Google Scholar 

  143. Levine AJ, Siegmund KD, Ervin CM, et al. The methylenetetrahydrofolate reductase 677C → T polymorphism and distal colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev 2000; 9:657–63.

    PubMed  CAS  Google Scholar 

  144. Ulrich CM, Kampman E, Bigler J, et al. Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction? Cancer Epidemiol Biomarkers Prev 1999; 8:659–68.

    PubMed  CAS  Google Scholar 

  145. Marugame T, Tsuji E, Inoue H, et al. Methyl-enetetrahydrofolate reductase polymorphism and risk of colorectal adenomas. Cancer Lett 2000; 151:181–6.

    Article  PubMed  CAS  Google Scholar 

  146. Baron JA. Large bowel adenomas: markers of risk and endpoints. J Cellular Biochem—Suppl 1996; 25:142–8.

    CAS  Google Scholar 

  147. DeCosse JJ, Miller HH, Lesser ML. Effect of wheat fiber and vitamins C and E on rectal polyps in patients with familial adenomatous polyposis. J Natl Cancer Inst 1989; 81:1290–7.

    PubMed  CAS  Google Scholar 

  148. MacLennan R, Macrae F, Bain C, et al. Randomized trial of intake of fat, fiber, and beta carotene to prevent colorectal adenomas. The Australian Polyp Prevention Project. J Natl Cancer Inst 1995; 87:1760–6.

    PubMed  CAS  Google Scholar 

  149. Alberts DS, Elena M, Roe DJ, et al. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. N Engl J Med 2000; 342:1156–62.

    Article  PubMed  CAS  Google Scholar 

  150. McKeown-Eyssen GE, Bright-See E, Bruce WR, et al. A randomized trial of a low fat high fibre diet in the recurrence of colorectal polyps. Toronto Polyp Prevention Group [published erratum in J Clin Epidemiol 1995; 48:i]. J Clin Epidemiol 1994; 47:525–36.

    Article  PubMed  CAS  Google Scholar 

  151. Schatzkin A, Lanza E, Corle D, et al. Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. N Engl J Med 2000; 342:1149–55.

    Article  PubMed  CAS  Google Scholar 

  152. Greenberg ER, Baron JA, Tosteson TD, et al. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. Polyp Prevention Study Group. New Engl J Med 1994; 331:141–7.

    PubMed  CAS  Google Scholar 

  153. McKeown-Eyssen G, Holloway C, Jazmaji V, et al. A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps. Cancer Res 1988; 48:4701–5.

    PubMed  CAS  Google Scholar 

  154. Bussey HJ, DeCosse JJ, Deschner EE, et al. A randomized trial of ascorbic acid in polyposis coli. Cancer 1982; 50:1434–9.

    PubMed  CAS  Google Scholar 

  155. Paspatis G, Xourgias B, Mylonakou E, et al. A prospective clinical trial to determine the influence of folate supplementation on the formation of recurrent colonic adenomas (abstr.). Gastroenterology 1994; 106:A425.

    Google Scholar 

  156. Baron JA, Beach M, Mandel JS, et al. Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group. N Engl J Med 1999; 340:101–7.

    PubMed  CAS  Google Scholar 

  157. Bonithon-Kopp C, Kronborg O, Giacosa A, et al. Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. Lancet 2000; 356:1300–6.

    PubMed  CAS  Google Scholar 

  158. Labayle D, Fischer D, Vielh P, et al. Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastroenterology 1991; 101:635–9.

    PubMed  CAS  Google Scholar 

  159. Giardiello FM, Hamilton SR, Krush AJ, et al. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med 1993; 328:1313–16.

    Article  PubMed  CAS  Google Scholar 

  160. Nugent KP, Farmer KC, Spigelman AD, et al. Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. Brit J Surg 1993; 80:1618–19.

    PubMed  CAS  Google Scholar 

  161. Steinbach G, Lynch PM, Phillips RK, et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med 2000; 342:1946–52.

    Article  PubMed  CAS  Google Scholar 

  162. Hixson LJ, Earnest DL, Fennerty MB, et al. NSAID effect on sporadic colon polyps. Am J Gastroenterol 1993; 88:1652–6.

    PubMed  CAS  Google Scholar 

  163. Ladenheim J, Garcia G, Titzer D, et al. Effect of sulindac on sporadic colonic polyps. Gastroenterology 1995; 108:1083–7.

    Article  PubMed  CAS  Google Scholar 

  164. DiSario J, Alberts DS, Tietze CC, et al. Sulindac Induces Regression and Prevents Progression of Sporadic Colorectal Adenomas. Gastroenterology 1997; 112:A555.

    Google Scholar 

  165. Gann PH, Manson JE, Glynn RJ, et al. Low-dose aspirin and incidence of colorectal tumors in a randomized trial. J Natl Cancer Inst 1993; 85:1220–4.

    PubMed  CAS  Google Scholar 

  166. Demers RY, Stawick LE, Demers P. Relative sensitivity of the fecal occult blood test and flexible sigmoidoscopy in detecting polyps. Prev Med 1985; 14:55–62.

    Article  PubMed  CAS  Google Scholar 

  167. Ransohoff DF, Lang CA. Small adenomas detected during fecal occult blood test screening for colorectal cancer. The impact of serendipity. JAMA 1990; 264:76–8.

    Article  PubMed  CAS  Google Scholar 

  168. St John DJ, Young GP, Alexeyeff MA, et al. Evaluation of new occult blood tests for detection of colorectal neoplasia. Gastroenterology 1993; 104:1661–8.

    PubMed  CAS  Google Scholar 

  169. Ahlquist DA, Wieand HS, Moertel CG, et al. Accuracy of fecal occult blood screening for colorectal neoplasia. A prospective study using Hemoccult and HemoQuant tests. JAMA 1993; 269:1262–7.

    Article  PubMed  CAS  Google Scholar 

  170. Hope RL, Chu G, Hope AH, et al. Comparison of three faecal occult blood tests in the detection of colorectal neoplasia. Gut 1996; 39: 722–5.

    PubMed  CAS  Google Scholar 

  171. Villa E, Dugani A, Rebecchi AM, et al. Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool. Gastroenterology 1996; 110:1346–53.

    Article  PubMed  CAS  Google Scholar 

  172. Dutta SK, Nair PP. Noninvasive detection of colorectal cancer by molecular tools: coming of age. Gastroenterology 1998; 114:1333–5.

    Article  PubMed  CAS  Google Scholar 

  173. Ahlquist DA, Skoletsky JE, Boynton KA, et al. Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel. Gastroenterology 2000; 119:1219–27.

    Article  PubMed  CAS  Google Scholar 

  174. Kopreski MS, Benko FA, Borys DJ, et al. Somatic mutation screening: identification of individuals harboring K-ras mutations with the use of plasma DNA. J Natl Cancer Inst 2000; 92:918–23.

    Article  PubMed  CAS  Google Scholar 

  175. Williams G. Metaplastic polyposis. In: Spigelman A, Thomson J, (eds) Familial adenomatous polyposis and other polyposis syndromes. London: Arnold, 1994, pp. 174–87.

    Google Scholar 

  176. Spjut H, Estrada RG. The significance of epithelial polyps of the large bowel. Pathol Ann 1977; 12(Pt 1):147–70.

    Google Scholar 

  177. Williams AR, Balasooriya BA, Day DW. Polyps and cancer of the large bowel: a necropsy study in Liverpool. Gut 1982; 23:835–42.

    PubMed  CAS  Google Scholar 

  178. Correa P, Strong JP, Reif A, et al. The epidemiology of colorectal polyps: prevalence in New Orleans and international comparisons. Cancer 1977; 39:2258–64.

    PubMed  CAS  Google Scholar 

  179. Clark JC, Collan Y, Eide TJ, et al. Prevalence of polyps in an autopsy series from areas with varying incidence of large-bowel cancer. Int J Cancer 1985; 36:179–86.

    PubMed  CAS  Google Scholar 

  180. DiSario JA, Foutch PG, Mai HD, et al. Prevalence and malignant potential of colorectal polyps in asymptomatic, average-risk men. Am J Gastroenterol 1991; 86:941–5.

    PubMed  CAS  Google Scholar 

  181. Jass JR, Young PJ, Robinson EM. Predictors of presence, multiplicity, size and dysplasia of colorectal adenomas. A necropsy study in New Zealand. Gut 1992; 33:1508–14.

    PubMed  CAS  Google Scholar 

  182. Hayashi T, Yatani R, Apostol J, et al. Pathogenesis of hyperplastic polyps of the colon: a hypothesis based on ultrastructure and in vitro cell kinetics. Gastroenterol 1974; 66:347–56.

    CAS  Google Scholar 

  183. Kikuchi Y, Dinjens WN, Bosman FT. Proliferation and apoptosis in proliferative lesions of the colon and rectum. Virchows Archiv 1997; 431:111–7.

    Article  PubMed  CAS  Google Scholar 

  184. Barletta A, Marzullo F, Pellecchia A, et al. DNA flow cytometry, p53 levels and proliferative cell nuclear antigen in human colon dysplastic, precancerous and cancerous tissues. Anticancer Res 1998; 18:1677–82.

    PubMed  CAS  Google Scholar 

  185. Iwabuchi M, Sasano H, Hiwatashi N, et al. Serrated adenoma: a clinicopathological, DNA ploidy, and immunohistochemical study. Anticancer Res 2000; 20:1141–7.

    PubMed  CAS  Google Scholar 

  186. Shpitz B, Bomstein Y, Mekori Y, et al. Proliferating cell nuclear antigen as a marker of cell kinetics in aberrant crypt foci, hyperplastic polyps, adenomas, and adenocarcinomas of the human colon. Am J Surg 1997; 174:425–30.

    Article  PubMed  CAS  Google Scholar 

  187. Kang M, Mitomi H, Sada M, et al. Ki-67, p53, and Bcl-2 expression of serrated adenomas of the colon. Am J Surg Pathol 1997; 21:417–23.

    Article  PubMed  CAS  Google Scholar 

  188. Araki K, Ogata T, Kobayashi M, et al. A morphological study on the histogenesis of human colorectal hyperplastic polyps. Gastroenterology 1995; 109:1468–74.

    Article  PubMed  CAS  Google Scholar 

  189. Frazin G, Zamboni G, Scarpa A, et al. Hyperplastic (metaplastic) polyps of the colon. A histologic and histochemical study. Am J Surg Pathol 1984; 8:687–98.

    PubMed  CAS  Google Scholar 

  190. Bensen S, Cole B, Mott L, et al. Colorectal hyperplastic polyps and risk of recurrence of adenomas and hyperplastic polyps. Lancet 1999; 354:1873–4.

    Article  PubMed  CAS  Google Scholar 

  191. Imperiale TF, Wagner DR, Lin CY, et al. Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med 2000; 343:169–74.

    Article  PubMed  CAS  Google Scholar 

  192. Croizet O, Moreau J, Arany Y, et al. Follow-up of patients with hyperplastic polyps of the large bowel. Gastrointest Endoscopy 1997; 46:119–23.

    CAS  Google Scholar 

  193. Kearney J, Giovannucci E, Rimm EB, et al. Diet, alcohol, and smoking and the occurrence of hyperplastic polyps of the colon and rectum (United States). Cancer Causes Control 1995; 6:45–56.

    Article  PubMed  CAS  Google Scholar 

  194. Martinez ME, McPherson RS, Levin B, et al. A case-control study of dietary intake and other lifestyle risk factors for hyperplastic polyps. Gastroenterology 1997; 113:423–9.

    Article  PubMed  CAS  Google Scholar 

  195. Iino H, Jass JR, Simms LA, et al. DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer? J Clin Pathol 1999; 52:5–9.

    PubMed  CAS  Google Scholar 

  196. Cooper HS, Patchefsky AS, Marks G. Adenomatous and carcinomatous changes within hyperplastic colonic epithelium. Dis Colon Rectum 1979; 22:152–6.

    PubMed  CAS  Google Scholar 

  197. Franzin G, Novelli P. Adenocarcinoma occurring in a hyperplastic (metaplastic) polyp of the colon. Endoscopy 1982; 14:28–30.

    PubMed  CAS  Google Scholar 

  198. McCann BG. A case of metaplastic polyposis of the colon associated with focal adenomatous change and metachronous adenocarcinomas. Histopathology 1988; 13:700–2.

    PubMed  CAS  Google Scholar 

  199. Teoh HH, Delahunt B, Isbister WH. Dysplastic and malignant areas in hyperplastic polyps of the large intestine. Pathology 1989; 21:138–42.

    PubMed  CAS  Google Scholar 

  200. Jass J, Iino H, Ruszkiewicz A, et al. Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. Gut 2000; 47:43–9.

    Article  PubMed  CAS  Google Scholar 

  201. Orii S, Nakamura S, Sugai T, et al. Hyperplastic (metaplastic) polyposis of the colorectum associated with adenomas and an adenocarcinoma. J Clin Gastroenterol 1997; 25:369–72.

    Article  PubMed  CAS  Google Scholar 

  202. Azimuddin K, Stasik JJ, Khubchandani IT, et al. Hyperplastic Polyps: “More than Meets the Eye?” Dis Colon Rectum 2000; 43:1309–1

    PubMed  CAS  Google Scholar 

  203. Jorgensen H, Mogensen AM, Svendsen LB. Hyperplastic polyposis of the large bowel. Three cases and a review of the literature. Scand J Gastroenterol 1996; 31:825–30.

    PubMed  CAS  Google Scholar 

  204. Rashid A, Houlihan P, Booker S, et al. Phenotypic and molecular characteristics of hyperplastic polyposis. Gastroenterology 2000; 119: 323–32.

    Article  PubMed  CAS  Google Scholar 

  205. Iino H, Simms L, Young J, et al. DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer. Gut 2000; 47:37–42.

    Article  PubMed  CAS  Google Scholar 

  206. Hiyama T, Yokozaki H, Shimamoto F, et al. Frequent p53 gene mutations in serrated adenomas of the colorectum. J Pathol 1998; 186:131–9.

    Article  PubMed  CAS  Google Scholar 

  207. Jen J, Powell SM, Papadopoulos N, et al. Molecular determinants of dysplasia in colorectal lesions. Cancer Res 1994; 54:5523–6.

    PubMed  CAS  Google Scholar 

  208. Otori K, Oda Y, Sugiyama K, et al. High frequency of K-ras mutations in human colorectal hyperplastic polyps. Gut 1997; 40:660–3.

    PubMed  CAS  Google Scholar 

  209. Nucci MR, Robinson CR, Longo P, et al. Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa. Hum Pathol 1997; 28:1396–407.

    Article  PubMed  CAS  Google Scholar 

  210. Lothe RA, Andersen SN, Hofstad B, et al. Deletion of 1p loci and microsatellite instability in colorectal polyps. Genes, Chromosomes Cancer 1995; 14:182–8.

    PubMed  CAS  Google Scholar 

  211. Torlakovic E, Snover DC. Serrated adenomatous polyposis in humans. Gastroenterology 1996; 110:748–55.

    Article  PubMed  CAS  Google Scholar 

  212. Konishi M, Kikuchi-Yanoshita R, Tanaka K, et al. Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology 1996; 111:307–17.

    PubMed  CAS  Google Scholar 

  213. Jaramillo E, Watanabe M, Rubio C, et al. Small colorectal serrated adenomas: endoscopic findings. Endoscopy 1997; 29:1–3.

    PubMed  CAS  Google Scholar 

  214. Longacre TA, Fenoglio-Preiser CM, Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia. Am J Surg Pathol 1990; 14:524–37.

    PubMed  CAS  Google Scholar 

  215. Ajioka Y, Watanabe H, Jass JR, et al. Infrequent K-ras codon 12 mutation in serrated adenomas of human colorectum. Gut 1998; 42:680–4.

    PubMed  CAS  Google Scholar 

  216. Uchida H, Ando H, Maruyama K, et al. Genetic alterations of mixed hyperplastic adenomatous polyps in the colon and rectum. Jap J Cancer Res 1998; 89:299–306.

    CAS  Google Scholar 

  217. Yao T, Kouzuki T, Kajiwara M, et al. “Serrated” adenoma of the colorectum, with reference to its gastric differentiation and its malignant potential. J Pathol 1999; 187:511–17.

    Article  PubMed  CAS  Google Scholar 

  218. Rubio CA, Rodensjo M. p53 overexpression in flat serrated adenomas and flat tubular adenomas of the colorectal mucosa. J Cancer Res Clin Oncol 1995; 121:571–6.

    Article  PubMed  CAS  Google Scholar 

  219. Jass JR, Biden KG, Cummings MC, et al. Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways. J Clin Pathol 1999; 52: 455–60.

    PubMed  CAS  Google Scholar 

  220. Matsumoto T, Mizuno M, Shimizu M, et al. Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma. J Clin Pathol 1999; 52: 513–16.

    PubMed  CAS  Google Scholar 

  221. Fenoglio-Preiser C, Noffsinger A. Aberrant crypt foci: a review. Toxicol Pathol 1999; 27:632–42.

    PubMed  CAS  Google Scholar 

  222. Nascimbeni R, Villanacci V, Mariani PP, et al. Aberrant crypt foci in the human colon: frequency and histologic patterns in patients with colorectal cancer or diverticular disease. Am J Surg Pathol 1999; 23:1256–63.

    Article  PubMed  CAS  Google Scholar 

  223. Pretlow TP. Aberrant crypt foci and K-ras mutations: earliest recognized players or innocent bystanders in colon carcinogenesis? Gastroenterology 1995; 108:600–3.

    Article  PubMed  CAS  Google Scholar 

  224. Siu IM, Pretlow TG, Amini SB, et al. Identification of dysplasia in human colonic aberrant crypt foci. Am J Pathol 1997; 150:1805–13.

    PubMed  CAS  Google Scholar 

  225. McLellan EA, Medline A, Bird RP. Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: putative preneoplastic lesions. Cancer Res 1991; 51:5270–4.

    PubMed  CAS  Google Scholar 

  226. Bird RP. Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 1995; 93:55–71.

    Article  PubMed  CAS  Google Scholar 

  227. Pretlow TP, O’Riordan MA, Pretlow TG, et al. Aberrant crypts in human colonic mucosa: putative preneoplastic lesions. J Cell Biochem 1992; (16G Suppl):55–62.

    Google Scholar 

  228. Shpitz B, Hay K, Medline A, et al. Natural history of aberrant crypt foci. A surgical approach. Dis Colon Rectum 1996; 39:763–7.

    Article  PubMed  CAS  Google Scholar 

  229. Wargovich MJ, Chen CD, Jimenez A, et al. Aberrant crypts as a biomarker for colon cancer: evaluation of potential chemopreventive agents in the rat. Cancer Epidemiol Biomarkers Prev 1996; 5:355–60.

    PubMed  CAS  Google Scholar 

  230. Olivo S, Wargovich MJ. Inhibition of aberrant crypt foci by chemopreventive agents. In Vivo 1998; 12:159–66.

    PubMed  CAS  Google Scholar 

  231. Takayama T, Katsuki S, Takahashi Y, et al. Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med 1998; 339:1277–84.

    Article  PubMed  CAS  Google Scholar 

  232. Roncucci L, Medline A, Bruce WR. Classification of aberrant crypt foci and microadenomas in human colon. Cancer Epidemiol Biomarkers Prev 1991; 1:57–60.

    PubMed  CAS  Google Scholar 

  233. Roncucci L, Scalmati A, Ponz de Leon M. Pattern of cell kinetics in colorectal mucosa of patients with different types of adenomatous polyps of the large bowel. Cancer 1991; 68:873–8.

    PubMed  CAS  Google Scholar 

  234. Shpitz B, Bomstein Y, Mekori Y, et al. Aberrant crypt foci in human colons: distribution and histomorphologic characteristics. Hum Pathol 1998; 29:469–75.

    Article  PubMed  CAS  Google Scholar 

  235. Bouzourene H, Chaubert P, Seelentag W, et al. Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease. Hum Pathol 1993; 30:66–71.

    Google Scholar 

  236. Yamashita N, Minamoto T, Ochiai A, et al. Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon. Gastroenterology 1995; 108:434–40.

    Article  PubMed  CAS  Google Scholar 

  237. Roncucci L, Modica S, Pedroni M, et al. Aberrant crypt foci in patients with colorectal cancer. Brit J Cancer 1998; 77:2343–8.

    PubMed  CAS  Google Scholar 

  238. Konstantakos AK, Siu IM, Pretlow TG, et al. Human aberrant crypt foci with carcinoma in situ from a patient with sporadic colon cancer. Gastroenterology 1996; 111:772–7.

    Article  PubMed  CAS  Google Scholar 

  239. Augenlicht LH, Richards C, Corner G, et al. Evidence for genomic instability in human colonic aberrant crypt foci. Oncogene 1996; 12:1767–72.

    PubMed  CAS  Google Scholar 

  240. Polyak K, Hamilton SR, Vogelstein B, et al. Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia. Am J Pathol 1996; 149:381–7.

    PubMed  CAS  Google Scholar 

  241. Heinen CD, Shivapurkar N, Tang Z, et al. Microsatellite instability in aberrant crypt foci from human colons. Cancer Res 1996; 56:5339–41.

    PubMed  CAS  Google Scholar 

  242. Siu IM, Robinson DR, Schwartz S, et al. The identification of monoclonality in human aberrant crypt foci. Cancer Res 1999; 59:63–6.

    PubMed  CAS  Google Scholar 

  243. Pretlow TP, Brasitus TA, Fulton NC, et al. K-ras mutations in putative preneoplastic lesions in human colon. J Natl Cancer Inst 1993; 85:2004–7.

    PubMed  CAS  Google Scholar 

  244. Smith AJ, Stern HS, Penner M, et al. Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons. Cancer Res 1994; 54:5527–30.

    PubMed  CAS  Google Scholar 

  245. Otori K, Konishi M, Sugiyama K, et al. Infrequent somatic mutation of the adenomatous polyposis coli gene in aberrant crypt foci of human colon tissue. Cancer 1998; 83:896–900.

    Article  PubMed  CAS  Google Scholar 

  246. Losi L, Roncucci L, di Gregorio C, et al. K-ras and p53 mutations in human colorectal aberrant crypt foci. J Pathol 1996; 178:259–63.

    Article  PubMed  CAS  Google Scholar 

  247. Otori K, Sugiyama K, Hasebe T, et al. Emergence of adenomatous aberrant crypt foci (ACF) from hyperplastic ACF with concomitant increase in cell proliferation. Cancer Res 1995; 55:4743–6.

    PubMed  CAS  Google Scholar 

  248. Guillem JG, Smith AJ, Calle JP, et al. Gastrointestinal polyposis syndromes. Curr Probl Surg 1999; 36:217–323.

    PubMed  CAS  Google Scholar 

  249. Giardiello FM, Welsh SB, Hamilton SR, et al. Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med 1987; 316:1511–14.

    PubMed  CAS  Google Scholar 

  250. Boardman LA, Thibodeau SN, Schaid DJ, et al. Increased risk for cancer in patients with the Peutz-Jeghers syndrome. Ann Int Med 1998; 128:896–9.

    PubMed  CAS  Google Scholar 

  251. Giardiello FM, Brensinger JD, Tersmette AC, et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 2000; 119: 1447–53.

    Article  PubMed  CAS  Google Scholar 

  252. Flageole H, Raptis S, Trudel JL, et al. Progression toward malignancy of hamartomas in a patient with Peutz-Jeghers syndrome: case report and literature review. Can J Surg 1994; 37:231–6.

    PubMed  CAS  Google Scholar 

  253. Miller LJ, Bartholomew LG, Dozois RR, et al. Adenocarcinoma of the rectum arising in a hamartomatous polyp in a patient with Peutz-Jeghers syndrome. Digest Dis Sci 1983; 28: 1047–51.

    PubMed  CAS  Google Scholar 

  254. Hizawa K, Iida M, Matsumoto T, et al. Neoplastic transformation arising in Peutz-Jeghers polyposis. Dis Colon Rectum 1993; 36:953–7.

    Article  PubMed  CAS  Google Scholar 

  255. Niimi K, Tomoda H, Furusawa M, et al. Peutz-Jeghers syndrome associated with adenocarcinoma of the cecum and focal carcinomas in hamartomatous polyps of the colon: a case report. Jap J Surg 1991; 21:220–3.

    CAS  Google Scholar 

  256. Bosman FT. The hamartoma-adenoma-carcinoma sequence. J Pathol 1999; 188:1–2.

    Article  PubMed  CAS  Google Scholar 

  257. Wang ZJ, Ellis I, Zauber P, et al. Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers’ syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence. J Pathol 1999; 188:9–13.

    Article  PubMed  CAS  Google Scholar 

  258. Perzin KH, Bridge MF. Adenomatous and carcinomatous changes in hamartomatous polyps of the small intestine (Peutz-Jeghers syndrome): report of a case and review of the literature. Cancer 1982; 49:971–83.

    PubMed  CAS  Google Scholar 

  259. Nugent KP, Talbot IC, Hodgson SV, et al. Solitary juvenile polyps: not a marker for subsequent malignancy. Gastroenterology 1993; 105: 698–700.

    PubMed  CAS  Google Scholar 

  260. Desai DC, Neale KF, Talbot IC, et al. Juvenile polyposis. Br J Surg 1995; 82:14–17.

    PubMed  CAS  Google Scholar 

  261. Howe JR, Roth S, Ringold JC, et al. Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science 1998; 280:1086–8.

    Article  PubMed  CAS  Google Scholar 

  262. Jarvinen H, Franssila KO. Familial juvenile polyposis coli; increased risk of colorectal cancer. Gut 1984; 25:792–800.

    PubMed  CAS  Google Scholar 

  263. O’Riordain DS, O’Dwyer PJ, Cullen AF, et al. Familial juvenile polyposis coli and colorectal cancer. Cancer 1991; 68:889–92.

    PubMed  CAS  Google Scholar 

  264. Jacoby RF, Schlack S, Cole CE, et al. A juvenile polyposis tumor suppressor locus at 10q22 is deleted from nonepithelial cells in the lamina propria. Gastroenterology 1997; 112:1398–403.

    Article  PubMed  CAS  Google Scholar 

  265. Wu TT, Rezai B, Rashid A, et al. Genetic alterations and epithelial dysplasia in juvenile polyposis syndrome and sporadic juvenile polyps. Am J Pathol 1997; 150:939–47.

    PubMed  CAS  Google Scholar 

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Authors
  1. John A. Baron
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Editors and Affiliations

  1. Departments of Oncology and Epidemiology, McGill University, Montreal, Quebec, H2W 1S6, Canada

    Eduardo L. Franco MPH, DrPH (Professor, Director) (Professor, Director)

  2. Division of Cancer Epidemiology, McGill University, Montreal, Quebec, H2W 1S6, Canada

    Eduardo L. Franco MPH, DrPH (Professor, Director) (Professor, Director)

  3. Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Thomas E. Rohan MB, BS, PhD (Professor and Chairman) (Professor and Chairman)

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© 2002 Springer-Verlag New York, Inc.

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Baron, J.A. (2002). Colon and Rectum. In: Franco, E.L., Rohan, T.E. (eds) Cancer Precursors. Springer, New York, NY. https://doi.org/10.1007/0-387-21605-7_10

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  • DOI: https://doi.org/10.1007/0-387-21605-7_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-95188-1

  • Online ISBN: 978-0-387-21605-8

  • eBook Packages: Springer Book Archive

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