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References
Cancer Statistics, 1999. CA Cancer J Clin. 1999;49(1):12–13.
Douglass H. Adjuvant therapy for pancreatic cancer. World J Surg. 1995;19:1701–1774.
Geer RJ, Brennan MF. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg. 1993;165:68–73.
Shibamoto Y, Manabe T, Baba M. High dose, external beam and introperative radiotherapy in the treatment of resectable pancreatic cancer. Int J Radiat Oncol Biol Phys. 1990;19:605–611.
Nitecki SS, Sarr MG, Colby TV, Van Heerden JA. Long-term survival after resection for ductal adenocarcinoma of the pancreas. Is it really improving? Ann Surg. 1995;221(1):59–66.
Piorkowski RJ, Believernicht SW, Lawrence W. Jr. Pancreatic and periampullary carcinoma: experience with 200 patients over a 12-year period. Am J Surg. 1982;143:189–192.
Gudjonsson B. Cancer of the pancreas: 50 years of surgery. Cancer. 1987;60:2284–2303.
Trede M, Chir B, Schwall G, Saeger H-D. Survival after pancreaticoduodenectomy. Ann Surg. 1990;21(4):447–458.
Yeo CJ, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy for cancer of the head of the pancreas. Two hundred and one patients. Ann Surg. 1995;221(6):721–731.
Gastrointestinal Tumor Study Group. Therapy of locally unresected pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads+5-Fluorouracil), and high dose radiation+5-Fluorouracil. Cancer. 1981;48:1705–1710.
Whittington R, Bryer MP, Haller DG, Solin LJ, Rosato EF. Adjuvant therapy of resected adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys. 1991;21:1137–1143.
Tepper J, Nardi G, Suit H. Carcinoma of the pancreas: review of MGH experience from 1963 to 1973—analysis of surgical failure and implications for radiation therapy. Cancer. 1976;37:1519–1524.
Kalser MH, Ellenberg SS. Pancreatic cancer: adjuvant combined radiation and chemotherapy following curative resection. Arch Surg. 1985;12:899–903.
Douglass HO, Strablein DM. Ten year follow-up of first generation surgical adjuvant studies of the Gastrointestinal Tumor Study Group. In: Salmon SE, ed. Adjuvant Therapy of Cancer. Vol 4. Philadelphia, Pa: WB Saunders; 1990:405–415.
Gastrointestinal Tumor Study Group. Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer. 1987;59:2006–2010.
Bakkevold KE, Arnesjo B, Dahl O, Kambestad B. Adjuvant combination chemotherapy (AMF) following radical resection of carcinoma of the pancreas and papilla of Vater—results of a controlled, prospective, randomized multicentre study. Eur J Cancer. 1993;29A(5):698–703.
Klinkenbijl JHG, Jeekel J, Sahmoud T, et al. Adjuvant radiotherapy and 5-Fluorouracil after curative resection of cancer of the pancreas and periampullary region—phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg. 1999;230(6):776–784.
Simon RM. Design and analysis of clinic trials. In: DeVita VT, Hellman S, Rosenberg SA, eds. Cancer: Principles & Practice of Oncology. 5th ed. Philadelphia, Pa: Lippincott-Raven; 1997:513–528.
Amano H, Takada T, Kato H. Five-year results of a randomized study of postoperative adjuvant chemotherapy for resected pancreatic-biliary carcinomas. Proceed ASCO. 1999;18:273a (#1049).
Neoptolemos JP, Kerr DJ, Beger H, et al. ESPAC-1 trial progress report: the European randomized adjuvant study comparing radiochemotherapy, 6 months chemotherapy and combination therapy versus observation in pancreatic cancer. Digestion. 1997;58:570–577.
Foo ML, Gunderson LL, Nagorney DM, et al. Patterns of failure in grossly resected pancreatic ductal adenocarcinoma treated with adjuvant irradiation+5-Fluorouracil. Int J Radiat Oncol Biol Phys. 1993;26:483–489.
Mohiuddin M, Rosato F, Schuricht A, Barbot D, Biermann W, Cantor R. Carcinoma of the pancreas—the Jefferson experience 1975–1988. Eur J Surg Oncol. 1994;20:13–20.
Yeo CJ, Hruban RH, Kern SE, et al. Adenocarcinomas of the pancreas; factors influencing outcome after pancreaticoduodenectomy—the John Hopkins experience. Cancer Bull. 1994;46(6):504–510.
Yeo CJ, Abrams RA, Grochow LB, et al. Pancreaticoduodenectomy for pancreatic adenocarcinoma: postoperative adjuvant chemoradiation improves survival. Ann Surg. 1997;225(5):621–636.
Haller DG, Mayer RJ, Gunderson LL, et al. Improving adjuvant therapy for rectal cancer by combining protracted infusion fluorouracil with radiation therapy after curative surgery. New Engl J Med. 1994;331(8):502–507.
Spitz FR, Abbruzzese JL, Lee JE, et al. Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas. J Clin Oncol. 1997;15(3):928–937.
Whittington R, Neuberg D, Tester WJ, Benson AB III, Haller DG. Protracted intravenous fluorouracil infusion with radiation therapy management of localized pancreaticobiliary carcinoma: a phase I Eastern Cooperative Group trial. J Clin Oncol. 1995;13:227–232.
Burris HA, Moore MJ, Anderson J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15(6):2403–2413.
Rothenberg ML, Moore MJ, Cripps MC, et al. A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer. Ann Oncol. 1996;7:347–353.
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Regine, W.F. (2002). Postoperative Adjuvant Therapy: Past, Present, and Future Trial Development. In: Evans, D.B., Pisters, P.W.T., Abbruzzese, J.L. (eds) Pancreatic Cancer. M. D. Anderson Solid Tumor Oncology Series. Springer, New York, NY. https://doi.org/10.1007/0-387-21600-6_20
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DOI: https://doi.org/10.1007/0-387-21600-6_20
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