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Molecular Epidemiology

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Book cover Pancreatic Cancer

Part of the book series: M. D. Anderson Solid Tumor Oncology Series ((MDA))

Summary

The severity of the pancreatic cancer problem and the scarcity of information on its etiology call for more research effort. Epidemiological studies have found that the incidence and mortality of pancreatic cancer increased for several decades earlier in this century but have tended to level off in recent years. Rates increase with age and are higher in males than females and higher in blacks than whites. Both genetic and environmental factors may play significant roles in the etiology of pancreatic cancer. Exposure to carcinogens through cigarette smoking, diet, and occupational contact may increase the risk of pancreatic cancer. This hypothesis is supported by the experimental evidence that (1) the pancreas has the capacity to activate carcinogens; (2) DNA adducts are detected in pancreas tissue; and (3) genotoxic compounds might be involved, as suggested by the mutation spectra in pancreatic tumors. We hope, with advances in molecular biology and new methods of molecular epidemiological approach, to develop the tools for identifying high-risk individuals in whom this deadly disease can be prevented. An understanding of the etiological and molecular events leading to the development of pancreatic carcinoma may provide a basis for the development of effective strategies for the prevention, early diagnosis, and treatment of this disease.

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References

  1. Devesa SS, Blot WJ, Stone BJ, et al. Recent cancer trends in the United States. J Natl Cancer Inst. 1995;87:175–182.

    CAS  PubMed  Google Scholar 

  2. Ahlgren JD. Epidemiology and risk factors in pancreatic cancer. Semin Oncol. 1996;23:241–250.

    CAS  PubMed  Google Scholar 

  3. Niederhuber J, Brennan MF, Menck HR. The national cancer data base report on pancreatic cancer. Cancer. 1995;76:1671–1677.

    CAS  PubMed  Google Scholar 

  4. Washaw LA, Fernandez Del Castillo C. Pancreatic carcinoma. N Engl J Med. 1992;326:455–465.

    Google Scholar 

  5. Tominaga A, Kuroishi T. Epidemiology of pancreatic cancer. Semin Surg Oncol. 1998;15:3–7.

    Article  CAS  PubMed  Google Scholar 

  6. Anderson KE, Potter JD, Mack TM. Pancreatic cancer. In: Schottenfeld D, Fraumeni JF Jr, eds. Cancer Epidemiology and Prevention. New York: Oxford University Press;1996:725–771.

    Google Scholar 

  7. Gold EB, Goldin SB. Epidemiology of and risk factors for pancreatic cancer. Surg Oncol Clin N Am. 1998;7:67–91.

    CAS  PubMed  Google Scholar 

  8. Lynch HT, Smyrk T, Kern SE, et al. Familial pancreatic cancer: a review. Semin Oncol. 1996;23:251–275.

    CAS  PubMed  Google Scholar 

  9. Lumadue JA, Griffin CA, Osman M, et al. Familial pancreatic cancer and the genetics of pancreatic cancer. Panc Neopl. 1995;75:845–855.

    CAS  Google Scholar 

  10. Hruban RH, Petersen GM, Ha PK, et al. Genetics of pancreatic cancer. Surg Oncol Clin N Am. 1998;7:1–23.

    CAS  PubMed  Google Scholar 

  11. Lowenfels AB, Maisonneuve P. Pancreatic cancer: development of a unifying etiologic concept. Ann N Y Acad Sci. 1999;880:191–200.

    Article  CAS  PubMed  Google Scholar 

  12. Whitcomb DC, Applebaum S, Martin SP. Hereditary pancreatitis and pancreatic carcinoma. Ann N Y Acad Sci. 1999;880:201–209.

    Article  CAS  PubMed  Google Scholar 

  13. Park JG, Park YJ, Wijnen JT, et al. Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing. Int J Cancer. 1999;82(4):516–519.

    Article  CAS  PubMed  Google Scholar 

  14. Goggins M, Schutte M, Lu J, et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res. 1996;56:5360–5364.

    CAS  PubMed  Google Scholar 

  15. Lal G, Liu G, Schmocker B, et al. Genetic susceptibility is an important risk factor for pancreatic cancer. Proc Am Assoc Cancer Res. 1999;40:A3078.

    Google Scholar 

  16. Mack TM, Yu MC, Hanisch R, et al. Pancreas cancer and smoking, beverage consumption, and past medical history. J Natl Cancer Inst. 1986;76:49–60.

    CAS  PubMed  Google Scholar 

  17. Silverman DT, Dunn JA, Hoover RN, et al. Cigarette smoking and pancreas cancer: a case-control study based on direct interview. J Natl Cancer Inst. 1994;86:1510–1516.

    CAS  PubMed  Google Scholar 

  18. Muscat JE, Stellman SD, Hoffman D, et al. Smoking and pancreatic cancer in men and women. Cancer Epidemiol Biomarkers Prev. 1997;6:15–19.

    CAS  PubMed  Google Scholar 

  19. Best EW. A Canadian Study of Smoking and Health. Ottawa: Department of National Health Welfare, 1996.

    Google Scholar 

  20. Floderus B, Cederlof R, Friberg L, et al. Smoking and mortality: a 21-year follow-up based on the Swedish Twin Registry. Int J Epidemiol. 1988;17(2):332–340.

    CAS  PubMed  Google Scholar 

  21. Doll R. Cancers weakly related to smoking. Br Med Bull. 1996;52(1):35–49.

    CAS  PubMed  Google Scholar 

  22. Hammond EC. Smoking in relation to the death rates of one million men and women. Natl Cancer Inst Monogr. 1966;19:126.

    Google Scholar 

  23. Hirayama T. Epidemiology of pancreatic cancer in Japan. Jpn J Clin Oncol. 1989;19(3):208–215.

    CAS  PubMed  Google Scholar 

  24. Hirayama T. Smoking in relation to the death rates of 265,118 men and women in Japan: a report on five years of follow-up. In: American Cancer Society’s 14th Science Writers Seminar, Clearwater Beach, FL, 1972.

    Google Scholar 

  25. Kahn HA. The Dorn study of smoking and mortality among US veterans: report on 81/2; years of observation. In: Epidemiological Approaches to the Study of Cancer and Other Chronic Diseases. Washington, DC: US Public Health Service, 1996.

    Google Scholar 

  26. Shibata A, Mack TM, Pazanini-Hill A, et al. A prospective study of pancreatic cancer in the elderly. Int J Cancer. 1994;58(1):46–49.

    CAS  PubMed  Google Scholar 

  27. Fernandez E, Vecchia CL, Decarli A. Attributable risks for pancreatic cancer in Northern Italy. Cancer Epidemiol Biomarkers Prev. 1996;5:23–27.

    CAS  PubMed  Google Scholar 

  28. Fraumeni JF. Cancers of the pancreas and biliary tract: epidemiological considerations. Cancer Res. 1975;35:3437–3446.

    PubMed  Google Scholar 

  29. Neugut AI, Ahsan H, Robinson E. Pancreas cancer as second primary malignancy. A population-based study. Cancer. 1995;76:589–592.

    CAS  PubMed  Google Scholar 

  30. Ji BT, Chow WH, Gridley G, et al. Dietary factors and the risk of pancreatic cancer: a case-control study in Shanghai, China. Cancer Epidemiol Biomarkers Prev. 1995;4:885–893.

    CAS  PubMed  Google Scholar 

  31. Soler M, Chatenoud L, La Vecchia C, et al. Diet, alcohol, coffee and pancreatic cancer: final results from an Italian study. Eur J Cancer Prev. 1998;7(6):455–460.

    CAS  PubMed  Google Scholar 

  32. Stephens FO. The increased incidence of cancer of the pancreas: is there a missing dietary factor? Can it be reversed? Aust N Z J Surg. 1999;69(5):331–335.

    Article  CAS  PubMed  Google Scholar 

  33. Silverman DT, Swanson CA, Gridley G, et al. Dietary and nutritional factors and pancreatic cancer: a case-control study based on direct interviews. J Natl Cancer Inst. 1998;90:1710–1719.

    Article  CAS  PubMed  Google Scholar 

  34. Carroll KK. Obesity as a risk factor for certain types of cancer. Lipids. 1998;33(11):1055–1059.

    CAS  PubMed  Google Scholar 

  35. Ghadirian P, Baillargeon J, Simard A, et al. Food habits and pancreatic cancer: a case-control study of the francophone community in Montreal, Canada. Cancer Epidemiol Biomarkers Prev. 1995;4:895–899.

    CAS  PubMed  Google Scholar 

  36. Knekt P, Steineck G, Jarvinen R, et al. Intake of fried meat and risk of cancer: a follow-up study in Finland. Int J Cancer. 1994;59(6):756–760.

    CAS  PubMed  Google Scholar 

  37. Ohba S, Nishi M, Miyake H. Eating habits and pancreatic cancer. Int J Pancreatol. 1996;20:37–42.

    CAS  PubMed  Google Scholar 

  38. Burney PG, Comstock GW, Morris JS. Serological precursors of cancer serum micronutrients and the subsequent risk of pancreatic cancer. Am J Clin Nutr. 1989;49:895–900.

    CAS  PubMed  Google Scholar 

  39. Stolzenberg-Solomon RZ, Albanes D, Nieto FJ, et al. Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers. J Natl Cancer Inst. 1999;91(6):535–541.

    Article  CAS  PubMed  Google Scholar 

  40. Durbec JP, Chevillotte G, Bidart JM, et al. Diet, alcohol, tobacco and risk of cancer of the pancreas: a case-control study. Br J Cancer. 1983;47:463–470.

    CAS  PubMed  Google Scholar 

  41. Heuch I, Kvale G, Jacobsen BK, et al. Use of alcohol, tobacco and coffee, and risk of pancreatic cancer. Br J Cancer. 1983;48:637–643.

    CAS  PubMed  Google Scholar 

  42. Silverman DT, Brown LM, Hoover RN, et al. Alcohol and pancreatic cancer in blacks and whites in the United States. Cancer Res. 1995;55:4899–4905.

    CAS  PubMed  Google Scholar 

  43. Bouchardy C, Clavel F, La Vecchia C, et al. Alcohol, beer and cancer of the pancreas. Int J Cancer. 1990;45:842–846.

    CAS  PubMed  Google Scholar 

  44. Bueno de Mesquita HB, Maisonneuve P, Moerman CJ, et al. Lifetime consumption of alcoholic beverages, tea, and coffee and exocrine carcinoma of the pancreas: a population-based case-control study in the Netherlands. Int J Cancer. 1992;50:514–522.

    CAS  PubMed  Google Scholar 

  45. Clavel F, Benhamou E, Auquier A, et al. Coffee, alcohol, smoking and cancer of the pancreas: a case-control study. Int J Cancer. 1989;43:17–21.

    CAS  PubMed  Google Scholar 

  46. Falk RT, Pickle LW, Fontham ET, et al. Life-style risk factors for pancreatic cancer in Louisiana: a case-control study. Am J Epidemiol. 1988;28:324–326.

    Google Scholar 

  47. Farrow DC, Davis S. Diet and the risk of pancreatic cancer in men. Am J Epidemiol. 1990;132:423–431.

    CAS  PubMed  Google Scholar 

  48. Mizuno S, Watanabe S, Nakamura K, et al. A multi-institute case-control study on the risk factors of developing pancreatic cancer. Jpn J Clin Oncol. 1992;22:286–291.

    CAS  PubMed  Google Scholar 

  49. Zatonski WA, Boyle P, Przewozniak K, et al. Cigarette smoking, alcohol, tea, and coffee consumption and pancreas cancer risk: a case-control study from Opole, Poland. Int J Cancer. 1993;53:601–607.

    CAS  PubMed  Google Scholar 

  50. Longnecker MP, Enger MS. Epidemiologic data on alcoholic beverage consumption and risk of cancer. Clin Chim Acta. 1996;246:121–141.

    Article  CAS  PubMed  Google Scholar 

  51. Thomas DB. Alcohol as a cause of cancer. Environ Health Perspect. 1995;103(suppl 8):153–160.

    PubMed  Google Scholar 

  52. Norell S, Ahlbom A, Olin R, et al. Occupational factors and pancreatic cancer. Br J Ind Med. 1986;43(11):775–778.

    CAS  PubMed  Google Scholar 

  53. Kauppinen T, Partanen T, Degerth R, et al. Pancreatic cancer and occupational exposures. Epidemiology. 1995;6:498–502.

    CAS  PubMed  Google Scholar 

  54. Ji BT, Silverman DT, Dosemeci M, et al. Occupation and pancreatic cancer risk in Shanghai, China. Am J Ind Med. 1999;35(1):76–81.

    Article  CAS  PubMed  Google Scholar 

  55. Park RM, Mirer FE. A survey of mortality at two automotive engine manufacturing plants. Am J Ind Med. 1996;30:664–673.

    CAS  PubMed  Google Scholar 

  56. Bardin JA, Eisen EA, Tolbert PE, et al. Mortality studies of machining fluid exposure in the automobile industry. V: A case-control study of pancreatic cancer. Am J Ind Med. 1997;32(3):240–247.

    Article  CAS  PubMed  Google Scholar 

  57. Garabrani DH, Held J, Langholz B, et al. DDT and related compounds and risk of pancreatic cancer. J Natl Cancer Inst. 1992;84:764–771.

    Google Scholar 

  58. Fryzek J, Garabrant DH, Harlow SD, et al. A case-control study of self-reported exposures to pesticides and pancreas cancer in Southern Michigan. Int J Cancer. 1997;72:62–67.

    Article  CAS  PubMed  Google Scholar 

  59. Jaga K, Brosius D. Pesticide exposure: human cancers on the horizon. Rev Environ Health. 1999;14(1):39–50.

    CAS  PubMed  Google Scholar 

  60. Kernan GJ, Ji BT, Dosemeci M, et al. Occupational risk factors for pancreatic cancer: a case-control study based on death certificates from 24 U.S. states. Am J Ind Med. 1999;36(2):260–270.

    Article  CAS  PubMed  Google Scholar 

  61. Anttila A, Pukkala E, Riala R, et al. Cancer incidence among Finnish workers exposed to aromatic hydrocarbons. Int Arch Occup Environ Health. 1998;71:187–193.

    CAS  PubMed  Google Scholar 

  62. Jarvholm B, Sanden A. Lung cancer and mesothelioma in the pleura and peritoneum among Swedish insulation workers. Occup Environ Med. 1998;55(11):766–770.

    CAS  PubMed  Google Scholar 

  63. Bueno de Mesquita HB, Maisonneuve P, Moerman CJ, et al. Aspects of medical history and exocrine carcinoma of the pancreas: a population-based case-control study in the Netherlands. Int J Cancer. 1992;52:17–23.

    CAS  PubMed  Google Scholar 

  64. La Vecchia C, Negri E, D’Avanzo B, et al. Medical history, diet and pancreatic cancer. Oncology. 1990;47(6):463–466.

    PubMed  Google Scholar 

  65. Lowenfels AB, Maisonneuve P, Gavallini G, et al. Pancreatitis and the risk of pancreatic cancer. N Eng J Med. 1993;328:1433–1437.

    CAS  Google Scholar 

  66. Ekbom A, McLaughlin JK, Nyren O, et al. Pancreatitis and pancreatic cancer: a population-based study. J Natl Cancer Inst. 1994;86:625–627.

    CAS  PubMed  Google Scholar 

  67. Talamini G, Falconi M, Bassi C, et al. Incidence of cancer in the course of chronic pancreatitis. Am J Gastrenterol. 1999;94(5):1253–1260.

    CAS  Google Scholar 

  68. Hecht SS. Approaches to cancer prevention based on an understanding of N-nitrosoamine carcinogenesis. Proc Soc Exp Biol Med. 1997;216(2):181–191.

    CAS  PubMed  Google Scholar 

  69. Wynder EL/, Mabuchi K, Marruchi N, et al. Epidemiology of cancer of the pancreas. J Natl Cancer Inst. 1973;50:645–667.

    CAS  PubMed  Google Scholar 

  70. Morgan RR, Wormsley K. Progress report: cancer of the pancreas. Gut. 1977;18:580–596.

    CAS  PubMed  Google Scholar 

  71. Harris CC, Autrup H, Stoner G, et al. Metabolism of benzo[a]pyrene and 7,12-dimethyl-benz[a]anthracene in cultured human bronchus and pancreatic duct. Cancer Res. 1977;37:3349–3355.

    CAS  PubMed  Google Scholar 

  72. Foster JR, Idle JR, Hardwick JP, et al. Induction of drug-metabolizing enzymes in human pancreatic cancer and chronic pancreatitis. J Pathol. 1993;169:457–463.

    Article  CAS  PubMed  Google Scholar 

  73. Wacke R, Kirchner A, Prall F, et al. Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis. Pancreas. 1998;16:521–528.

    Article  CAS  PubMed  Google Scholar 

  74. Chassagne P, Daujat M, Maurel P, et al. Cytochromes P-450 1A1 and 2E1 are present in human pancreas. Evidence by molecular biology. Gastroenterology. 1995;108:A348.

    Google Scholar 

  75. Anderson KE, Hammons GJ, Kadlubar FK, et al. Metabolic activation of aromatic amines by human pancreas. Carcinogenesis. 1997;18:1085–1092.

    Article  CAS  PubMed  Google Scholar 

  76. Collier JD, Bennett MK, Hall A, et al. Expression of glutathione S-transferases in normal and malignant pancreas: an immunohistochemical study. Gut. 1994;35:266–269.

    CAS  PubMed  Google Scholar 

  77. Rebbeck TR. Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility. Cancer Epiodemiol Biomarkers Prev. 1977;6:733–743.

    Google Scholar 

  78. Coles BF, Anderson KE, Doerge DR, et al. Quantitative analysis of interindividual variation of glutathione S-transferase expression in human pancreas and the ambiguity of correlating genotype with phenotype. Cancer Res. 2000;60:573–579.

    CAS  PubMed  Google Scholar 

  79. Lee HC, Yoon YB, Kim CY. Association between genetic polymorphisms of the cytochromes P-450 (1A1, 2D6, and 2E1) and the susceptibility to pancreatic cancer. Korean J Intern Med. 1997;12:128–136.

    CAS  PubMed  Google Scholar 

  80. Bartsch H, Malaveille C, Lowenfels AB, et al. Genetic polymorphism of N-acetyltransferases, glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase in relation to malignant and benign pancreatic disease risk. The International Pancreatic Disease Study Group. Eur J Cancer Prev. 1998;7(3):215–223.

    CAS  PubMed  Google Scholar 

  81. Kaderlik KR, Minchin RF, Mulder GJ, et al. Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-β]pyridine (PhIP) in rat extrahepatic tissues. Carcinogenesis. 1994;15:1703–1709.

    CAS  PubMed  Google Scholar 

  82. Kadlubar FF, Kaderlik KR, Mulder GJ, et al. Metabolic activation and DNA detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis. In Adamson RH, et al, eds, Heterocyclic Amines and Cooked Foods: Possible Human Carcinogens. Princeton, NJ: Scientific Publishing Co, Inc; 1995:207–213.

    Google Scholar 

  83. Cuzick J, Routledge MN, Jenkins D, et al. DNA adducts in different tissues of smokers and nonsmokers. Int J Cancer. 1990;45(4):673–678.

    CAS  PubMed  Google Scholar 

  84. Wang MY, Abbruzzese JL, Friess H, et al. DNA adducts in human pancreatic tissues and their potential role in carcinogenesis. Cancer Res. 1998;58:38–41.

    CAS  PubMed  Google Scholar 

  85. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A. 1993;90:7915–7922.

    CAS  PubMed  Google Scholar 

  86. Guyton KZ, Kensler TW. Oxidative mechanisms in carcinogenesis. Br Med Bull. 1993;49:523–544.

    CAS  PubMed  Google Scholar 

  87. Schoenberg MH, Buchler M, Gaspar M, et al. The involvement of oxygen radicals in acute pancreatitis. Gut. 1990;31:1138–1143.

    CAS  PubMed  Google Scholar 

  88. Schoenberg MH, Buchler M, Pietrzyk C, et al. Lipid peroxidation and glutathione metabolism in chronic pancreatitis. Pancreas. 1995;10:36–43.

    Article  CAS  PubMed  Google Scholar 

  89. Wereszcynska-Siemiatkowska U, Dabrowski A, Jedynak M, et al. Oxidative stress as an early prognostic factor in acute pancreatitis (AP): its correlation with serum phospholipase A2 (PLA2) and plasma polymorphonuclear elastase (PMN-E) in different-severity forms of human AP. Pancreas. 1998;17:163–168.

    Google Scholar 

  90. Nair J, Link KH, Beger HG, et al. Detection of elevated lipid peroxidation-induced etheno-DNA adducts in human chronic pancreatitis. Proc Am Assoc Cancer Res. 1999;40:A4256.

    Google Scholar 

  91. Thompson PA, Seyedi F, Lang NP, et al. Comparison of DNA adduct levels associated with exogenous and endogenous exposures in human pancreas in relation to metabolic genotype. Mutat Res. 1999;424(1–2):263–274.

    CAS  PubMed  Google Scholar 

  92. Kadlubar FF, Anderson KE, Häussermann S, et al. Comparison of DNA adduct levels associated with oxidative stress in human pancreas. Mutat Res. 1998;405(2):125–133.

    CAS  PubMed  Google Scholar 

  93. Marnett LJ. Lipid peroxidation-DNA damage by malondialdehyde. Mutat Res. 1999;424(1–2):83–95.

    CAS  PubMed  Google Scholar 

  94. Lau SS, Peters MMCG, Kleiner HE, et al. Biological reactive intermediates V. In: Snyder RR, et al, eds, Basic Mechanistic Research in Toxicology and Human Health Risk Assessment. New York: Plenum Press; 1996:267–273.

    Google Scholar 

  95. Li D, Friess H, Abbruzzese JL. 8-hydroxyguanine and other DNA damage in human pancreatic cancer. Proc Am Assoc Cancer Res. 1999;40:A4425.

    Google Scholar 

  96. Pegg AE. Methylation of the O6-position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents. Cancer Invest. 1984;2:223–231.

    CAS  PubMed  Google Scholar 

  97. Greenblatt MS, Bennett WP, Hollstein M, et al. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 1994;54:4855–4878.

    CAS  PubMed  Google Scholar 

  98. Hussain SP, Harris CC. Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes. Cancer Res. 1998;58:4023–4037.

    CAS  PubMed  Google Scholar 

  99. Blanck HM, Tolbert PE, Hoppin JA. Patterns of genetic alterations in pancreatic cancer: a pooled analysis. Environ Mol Mutagen. 1999;33(2):111–122.

    Article  CAS  PubMed  Google Scholar 

  100. Almoguera C, Shibata D, Forrester K, et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988;53:549–554.

    Article  CAS  PubMed  Google Scholar 

  101. Banerjee SK, Makdisi WF, Weston AP, et al. A two-step enriched-nested PCR technique enhances sensitivity for detection of codon 12 K-ras mutations in pancreatic adenocarcinoma. Pancreas. 1997;15:16–24.

    Article  CAS  PubMed  Google Scholar 

  102. Moskaluk CA, Hruban RH, Kern SE. p16 and Kras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res. 1997;57:2140–2143.

    CAS  PubMed  Google Scholar 

  103. Rall CJN, Yan YX, Graeme-Cook F, et al. Ki-ras and p53 mutations in pancreatic ductal adenocarcinoma. Pancreas. 1996;12:10–17.

    Article  CAS  PubMed  Google Scholar 

  104. Scarpa A, Capelli P, Villanueva A, et al. Pancreatic cancer in Europe: Ki-ras gene mutation pattern shows geographical differences. Int J Cancer. 1994;57:167–171.

    CAS  PubMed  Google Scholar 

  105. Berrozpe G, Schaeffer J, Peinado MA, et al. Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer. Int J Cancer. 1994;58:185–191.

    CAS  PubMed  Google Scholar 

  106. Cerny WL, Mangold KA, Scarpelli DG. K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster. Cancer Res. 1992;52:4507–4513.

    CAS  PubMed  Google Scholar 

  107. Schaeffer BK, Glasner S, Kuhlmann ET, et al. Mutated c-K-ras in small pancreatic adenocarcinomas. Pancreas. 1994;9:161–165.

    Article  CAS  PubMed  Google Scholar 

  108. Tada M, Omata M, Kawai S, et al. Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma. Cancer Res. 1993;53:2472–2474.

    CAS  PubMed  Google Scholar 

  109. Caldas C, Hahn SA, Hruban RH, et al. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia. Cancer Res. 1994;54:3568–3573.

    CAS  PubMed  Google Scholar 

  110. Abbruzzese JL, Evans DB, Raijman I, et al. Detection of mutated c-Ki-ras in the bile of patients with pancreatic cancer. Anticancer Res. 1997;17:795–801.

    CAS  PubMed  Google Scholar 

  111. Iguchi H, Sugano K, Fukayama N, et al. Analysis of Ki-ras codon 12 mutations in the duodenal juice of patients with pancreatic cancer. Gastroenterology. 1996;110:221–226.

    Article  CAS  PubMed  Google Scholar 

  112. Terhune PG, Phifer DM, Tosteson TD, et al. K-ras mutation in focal proliferative lesions of human pancreas. Cancer Epidemiol Biomarkers Prev. 1998;7:515–521.

    CAS  PubMed  Google Scholar 

  113. Malats N, Porta M, Corominas JM, et al. Ki-ras mutations in exocrine pancreatic cancer: association with clinico-pathological characteristics and with tobacco and alcohol consumption. Int J Cancer. 1997;70:661–667.

    Article  CAS  PubMed  Google Scholar 

  114. Hruban RH, van Mansfield ADM, Offerhaus GJA, et al. K-ras oncogene activation in adenocarcinoma of the human pancreas: a study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol. 1993;143:545–554.

    CAS  PubMed  Google Scholar 

  115. Nagata Y, Abe M, Motoshima K, et al. Frequent glycine-to-aspartic acid mutations at codon 12 of c-Ki-ras gene in human pancreatic cancer in Japanese. Jpn J Cancer Res. 1990;81:135–140.

    CAS  PubMed  Google Scholar 

  116. Berger DH, Chang H, Wood M, et al. Mutational activation of K-ras in non-neoplastic exocrine pancreatic lesions in relation to cigarette smoking status. Cancer. 1999;85(2):326–329.

    Article  CAS  PubMed  Google Scholar 

  117. Cooper GM. Role of oncogenes and tumor suppressor genes in the pathogenesis of neoplasms. In: Oncogene. Boston: Jones-Bartlett Publishers; 1990:141–162.

    Google Scholar 

  118. Sugio K, Gazdar AF, Albores-Saavedra J, et al. High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl) amine in the pancreas of female Syrian hamsters. Carcinogenesis. 1996;17:303–309.

    CAS  PubMed  Google Scholar 

  119. Cooper CA, Carey FA, Bubb VJ, et al. The pattern of K-ras mutation in pulmonary adenocarcinoma defines a new pathway of tumor development in the human lung. J Pathol. 1997;181:401–404.

    Article  CAS  PubMed  Google Scholar 

  120. Ringborg U. Alcohol and risk of cancer. Alcohol Clin Exp Res. 1998;22(7 suppl):323S–328S.

    CAS  PubMed  Google Scholar 

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Authors
  1. Donghui Li
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Editors and Affiliations

  1. Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA

    Douglas B. Evans M.D. (Professor of Surgery) & Peter W. T. Pisters M.D., F.A.C.S. (Associate Professor of Surgery) (Professor of Surgery) &  (Associate Professor of Surgery)

  2. Department of Gastrointestinal Medical Oncology, The University Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA

    James L. Abbruzzese M.D. (Professor of Medical Oncology, Chairman) (Professor of Medical Oncology, Chairman)

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Li, D. (2002). Molecular Epidemiology. In: Evans, D.B., Pisters, P.W.T., Abbruzzese, J.L. (eds) Pancreatic Cancer. M. D. Anderson Solid Tumor Oncology Series. Springer, New York, NY. https://doi.org/10.1007/0-387-21600-6_1

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  • DOI: https://doi.org/10.1007/0-387-21600-6_1

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-95185-0

  • Online ISBN: 978-0-387-21600-3

  • eBook Packages: Springer Book Archive

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